Recombinant Mouse Plexin-B1 (Plxnb1), partial

中文名稱：

小鼠Plxnb1重組蛋白
貨號：

CSB-YP810618MO
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Plxnb1重組蛋白
貨號：

CSB-EP810618MO
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Plxnb1重組蛋白
貨號：

CSB-EP810618MO-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Plxnb1重組蛋白
貨號：

CSB-BP810618MO
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Plxnb1重組蛋白
貨號：

CSB-MP810618MO
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Plxnb1
Uniprot No.：

Q8CJH3
別名：

Plxnb1; Kiaa0407; Plexin-B1
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Receptor for SEMA4D. Plays a role in GABAergic synapse development. Mediates SEMA4A- and SEMA4D-dependent inhibitory synapse development. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration.
基因功能參考文獻：
1. Plexin-B1 coordinates cell repolarization through RhoA-ROCK-mediated redistribution of Plexin-B1. PMID: 28635959
2. Deletion of plexin-B1, the high affinity receptor for semaphorin 4D, significantly (one-way ANOVA; p < 0.001) reduced thrombus weight (- 40%) in oxidative venous thrombosis. PMID: 23642655
3. Sema 4D/CD100 is not only a ligand for plexin B1 but also a direct signaling receptor in mediating Sema 4D/CD100-plexin B's biological functions. PMID: 23262975
4. In ErbB-2-overexpressing murine breast cancer, ablation of Plexin-B1 genes strongly reduced metastases. Plexin-B1 has no effect on tumorigenesis or tumor growth but is required for metastasis of ErbB-2-dependent breast cancers in vivo. PMID: 22378040
5. Semaphorin 4D-induced nitric oxide synthase (iNOS) and nitric oxide (NO) production are mediated through plexin-B1. PMID: 20038643
6. a lack of plexin-B1 did not impact on cortical development in vivo PMID: 19948886
7. LARG plays a critical role in plexin-B1 signaling to stimulate Rho activation and cytoskeletal reorganization. PMID: 12196628
8. binding of Sema 4D to Plexin B1 stimulates the tyrosine kinase activity of Met PMID: 12198496
9. Results suggest that plexin-A1 and B1 interact in the adult brain and transduce semaphorin 3A signaling in cooperation. PMID: 12559962
10. Plexin signaling uncouples cell substrate-adhesion from cytoskeletal dynamics required for cell migration and axon extension. PMID: 14734633
11. The mechanism of semaphorin D in the activation of the MAPK pathway via plexin-B1 is reported. PMID: 16187944
12. A possible role for plexin-B1 in ovarian follicle growth and steroidogenesis, most likely via the granulosa cells, is suggested. PMID: 16210013
13. In the ovarian follicle, the effect of Plexin-B1 is mediated by semaphorin-4D. PMID: 17376242
14. PlexinB1 plays a redundant role in mouse development and it is not strictly required for tumour induced angiogenesis PMID: 17519029
15. A loss of plexin-B1 expression in mice does not significantly impact the development of the nervous system. PMID: 17554007
16. A functional role for CD100 antigen/Plxnb1 interactions in epithelial branching morphogenesis during organogenesis is reported. PMID: 18799546
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亞細胞定位：

Cell membrane; Single-pass type I membrane protein.
蛋白家族：

Plexin family
組織特異性：

Detected in brain, heart, lung, liver, kidney, stomach, testis, uterus and placenta. Expressed in neurons and glia in the developing hippocampus.
數據庫鏈接：

KEGG: mmu:235611

STRING: 10090.ENSMUSP00000071966

UniGene: Mm.53862