Recombinant Mouse Phospholipase A-2-activating protein (Plaa)

中文名稱：

小鼠Plaa重組蛋白
貨號：

CSB-YP018107MO
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Plaa重組蛋白
貨號：

CSB-EP018107MO
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Plaa重組蛋白
貨號：

CSB-EP018107MO-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Plaa重組蛋白
貨號：

CSB-MP018107MO
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Plaa
Uniprot No.：

P27612
別名：

Plaa; Plap; Phospholipase A-2-activating protein; PLA2P; PLAP
種屬：

Mus musculus (Mouse)
蛋白長度：

Full length protein
表達區域：

1-794
氨基酸序列

MASGASRYRL SCSLPGHELD VRGLVCCLYP PGAFVSVSRD RTTRLWAPDS PNRGFTEMHC MSGHSNFVSC VCIIPSSDIY PHGLIATGGN DHNICIFSLD SPMPLYILKG HKDTVCSLSS GKFGTLLSGS WDTTAKVWLN DKCMMTLQGH TAAVWAVKIL PEQGLMLTGS ADKTIKLWKA GRCERTFLGH EDCVRGLAIL SETEFLSCAN DASIRRWQIT GECLEVYFGH TNYIYSISVF PNSKDFVTTA EDRSLRIWKH GECAQTIRLP AQSIWCCCVL ENGDIVVGAS DGIIRVFTES EERTASAEEI KAFERELSQA TIDSKTGDLG DINAEQLPGR EHLSEPGTRE GQTRLIRDGE RVEAYQWSVS DGRWIKIGDV VGSSGANQQT SGKVLYEGKE FDYVFSIDVN EGGPSYKLPY NVSDDPWLVA YNFLQKNDLN PMFLDQVAKF IIDNTKGQTL GLGNTSFSDP FTGGGRYVPG TSGPSNTVQT ADPFTGAGRY MPGSAGMDTT MTGVDPFTGN SAYRSAASKT VNIYFPKKEA LTFDQANPTQ ILGKLKELNG TAPEEKKLTE DDLVLLEKIL SLICNNSSEK PTAQQLQILW KAINWPEDIV FPALDILRLS IKHPNVNENF CNEKGDQFSS HLINLLNPKG KPANQLLALR TFCNCFVSQA GQKLMMSQRE SLMSHAIELK SGSNKNIHIA LATLTLNYSV CFHKDHNIEG KAQCLSVIST ILEVVQDLEA TFRLLVALGT LISDDSNAIQ LAKSLGVDSQ IKKYVSVSEP AKVSECCRLV LHLL
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Plays a role in protein ubiquitination, sorting and degradation through its association with VCP. Involved in ubiquitin-mediated membrane proteins trafficking to late endosomes in an ESCRT-dependent manner, and hence plays a role in synaptic vesicle recycling. May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes. Plays a role in cerebellar Purkinje cell development. Positively regulates cytosolic and calcium-independent phospholipase A2 activities in a tumor necrosis factor alpha (TNF-alpha)- or lipopolysaccharide (LPS)-dependent manner, and hence prostaglandin E2 biosynthesis.
基因功能參考文獻：
1. We demonstrate that PLAA is essential for neural function, through dual roles of (1) regulating post-endocytic trafficking of signaling receptors necessary for neural development and (2) directing sorting of synaptic vesicle (SV) components during recycling, essential for synaptic function. PMID: 28413018
2. miR-203 may regulate expression of the novel nociceptive mediator PLAA after incision. PMID: 22846677
3. Phospholipase A2 activating protein is required for 1alpha,25-dihydroxyvitamin D3 dependent rapid activation of protein kinase C via Pdia3 PMID: 22484374
亞細胞定位：

Nucleus. Cytoplasm. Cell junction, synapse.
蛋白家族：

WD repeat PLAP family
組織特異性：

Expressed in the brain, with highest levels in hippocampal neurons, cerebellar granular cell layer and Purkinje cells.
數據庫鏈接：

KEGG: mmu:18786

STRING: 10090.ENSMUSP00000102724

UniGene: Mm.490101