Recombinant Mouse Pericentriolar material 1 protein (Pcm1), partial

中文名稱：

小鼠Pcm1重組蛋白
貨號：

CSB-YP874161MO
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Pcm1重組蛋白
貨號：

CSB-EP874161MO
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Pcm1重組蛋白
貨號：

CSB-EP874161MO-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Pcm1重組蛋白
貨號：

CSB-BP874161MO
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Pcm1重組蛋白
貨號：

CSB-MP874161MO
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Pcm1
Uniprot No.：

Q9R0L6
別名：

Pcm1; Pericentriolar material 1 protein; PCM-1; mPCM-1
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Required for centrosome assembly and function. Essential for the correct localization of several centrosomal proteins including CEP250, CETN3, PCNT and NEK2. Required to anchor microtubules to the centrosome. Involved in the biogenesis of cilia.
基因功能參考文獻：
1. MicroRNA (miR)-128 regulates the proliferation and differentiation of neural progenitor cells by repressing pericentriolar material 1 (PCM1). PMID: 26883496
2. haploinsufficiency at the Pcm1 locus can induce a range of neuroanatomical and behavioral phenotypes that support the candidacy of this locus in neuropsychiatric disorders. PMID: 25697395
3. deletion of Htt in ependymal cells led to PCM1 mislocalization, alteration of the cilia layer, and hydrocephalus PMID: 21985783
4. results identify a novel role for PCM- 1 in cell cycle regulation, and indicate that PCM-1 must fulfill an essential function for cells to complete interphase PMID: 12112146
5. Pcm1 colocalized with centrosomal components in cytoplasmic granules surrounding nascent centrioles. Interfering with Pcm1 reduced the amount of centrosomal proteins at basal bodies but did not prevent centriole assembly. PMID: 17606865
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亞細胞定位：

Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasmic granule. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Cytoplasm, cytoskeleton, cilium basal body.
蛋白家族：

PCM1 family
組織特異性：

Expressed in the hippocampus and dentate gyrus, the columnar epithelial cells of bronchioles, the olfactory epithelium, the pericardium and the inner segment of the retina.
數據庫鏈接：

KEGG: mmu:18536

STRING: 10090.ENSMUSP00000039709

UniGene: Mm.117896