Recombinant Mouse Neuropilin-2 (Nrp2), partial

中文名稱：

小鼠Nrp2重組蛋白
貨號：

CSB-YP016092MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Nrp2重組蛋白
貨號：

CSB-EP016092MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Nrp2重組蛋白
貨號：

CSB-EP016092MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Nrp2重組蛋白
貨號：

CSB-BP016092MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Nrp2重組蛋白
貨號：

CSB-MP016092MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Nrp2
Uniprot No.：

O35375
別名：

Nrp2; Neuropilin-2; Vascular endothelial cell growth factor 165 receptor 2
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF.
基因功能參考文獻：
1. Nrp2-positive (Nrp2(+)) mitral cells (MCs, second-order neurons) play crucial roles in transmitting attractive social signals from the posteroventral main olfactory bulb to the anterior part of medial amygdala. In the MC-specific Nrp2 knockout mice, circuit formation of Nrp2(+) MCs and odour-induced attractive social responses are impaired. PMID: 28731029
2. data suggest that Sema3f and Nrp2 are dispensable for the exclusion of vessels from the cap mesenchyme during kidney development. PMID: 28929539
3. Study identifies NRP2 and ESL-1 as targets for polysialylation in murine microglia and human THP-1 macrophages and reveals a striking convergence in the regulation of the two polysialylated acceptors in the course of inflammatory activation. A pool of polysialylated NRP2 and ESL-1 is assembled after injury or in culture and its shedding is an early response to lipopolysaccharide-induced activation of microglia. PMID: 27159043
4. Sema3F-Npn-2/PlexA3 signaling is essential for cell surface AMPAR homeostatic downscaling in response to an increase in neuronal activity, Npn-2 associates with AMPA-type glutamate receptors PMID: 29154130
5. Sema3G induces cell collapse in an Nrp2/PlexinD1-dependent manner. PMID: 27880905
6. Sema3a-Nrp2 signaling along an unrecognized pancreatic developmental axis constitutes a chemoattractant system essential for generating the hallmark morphogenetic properties of pancreatic islets. PMID: 28893946
7. Nrp2 deficiency increased blood vessel permeability and decreased lymphatic vessel drainage during inflammation, highlighting the importance of the NRP2/SEMA3F pathway in the modulation of tissue swelling and resolution of postinflammatory edema. PMID: 27751443
8. These results point to a new role for NRP2 in the positioning of neurons during adult hippocampal neurogenesis, acting via the GSK3beta signaling pathway. PMID: 27687730
9. The authors demonstrate that expression of Semaphorin-3F in the outer hair cell region inhibits type I spiral ganglion neuron process extension by activating Neuropilin-2 receptors expressed on spiral ganglion neurons. PMID: 26302206
10. neuropilin-2 is developmentally regulated. PMID: 26680304
11. Data show that Chicken ovalbumin upstream promoter transcription factor II (COUP-TFII)-induced expression of Neuropilin-2 (Nrp2) and its down-regulation control the destination of preoptic area (POa)-derived GABAergic neurons. PMID: 26305926
12. Study demonstrates that polysialic acid-SynCAM 1 defines a subpopulation of NG2 cells and identifies the presence of polysialic acid-NRP2 in microglia PMID: 25752299
13. This study suggested that neuropilins play an essential role in coordinating NCC migration with fate specification. PMID: 25363691
14. High NRP2 expression is associated with medulloblastoma. PMID: 24026530
15. Npn2 is selectively expressed in distinct populations of commissural neurons in both the dorsal and ventral spinal cord. PMID: 23902858
16. Nrp2 contributes to the establishment of uncrossed projections by dopaminergic axons. PMID: 23534961
17. ST8SiaIV synthesized polySia selectively on a NRP2 glycoform that was characterized by the presence of sialylated core 1 and core 2 O-glycans. PMID: 23801331
18. these data point to a physiological role for Nrp2 in bone homeostasis PMID: 23598046
19. In the majority of lung, breast and colorectal cancers, the effects of anti-neuropilin-2 are likely to be restricted to the vasculature PMID: 22384800
20. These findings identify Nrp2 as a mediator of prorelaxant stimuli in smooth muscle cells and suggest a novel function for Nrp2 as a regulator of visceral smooth muscle contractility. PMID: 22688055
21. Loss of NRP2 or its ligand SEMA3F impaired sympathetic gangliogenesis more mildly than loss of SEMA3A/NRP1 signalling, but caused ectopic neurite extension along the embryonic aorta. PMID: 22790009
22. tumor cell-derived NRP-2 mediates critical survival signaling in gastrointestinal cancer cells PMID: 22028766
23. Neuropilin-2 promotes branching morphogenesis in the mouse mammary gland. PMID: 21693513
24. Vascular endothelial growth factor-D stimulates endothelial cell VEGF-A, stanniocalcin-1, and neuropilin-2 and has potent angiogenic effects. PMID: 21474827
25. These results suggest that the graded expression of neuropilin-2 in olfactory epithelium is required for the proper targeting of ventral glomeruli along the anterodorsal/posteroventral axis in the olfactory bulb. PMID: 20363325
26. neuropilin-2 transcriptional regulation by COUP-TFII modulates multiple steps in murine lymphatic vessel development PMID: 20364082
27. NRP2 expression dose not affect adult brain response to cerebral ischemia. PMID: 20036291
28. interaction between Nrp2 and VEGFR3 mediates proper lymphatic vessel sprouting in response to VEGF-C. PMID: 20065093
29. Npn-2 and candidate pheromone receptors play distinct and complementary roles in promoting the wiring and patterning of sensory neurons in the accessory olfactory system. PMID: 11906695
30. investigated the expression pattern following experimental cerebral ischemia PMID: 11939589
31. neuropilin 2 is selectively required for the formation of small lymphatic vessels and capillaries. PMID: 12361971
32. down-regulation of Neuropilin-2 expression may facilitate tangential interneuron migration from the basal forebrain PMID: 17259176
33. Genetic evidence for a Nrp2-Sema3f interaction as a determinant of the wiring of axons of gucy2d+ neurons into the unusual configuration of necklace glomeruli. PMID: 17942483
34. Nrp2, which was originally identified as an axon-guidance receptor, is an attractive target for modulating metastasis. PMID: 18394556
35. neuropilin-2 facilitates peripheral-nerve axonal regeneration. PMID: 18615644
36. The neuropilin 2 deficient mice had shorter seizure latencies, increased vulnerability to seizure-related death, were more likely to develop spontaneous recurrent seizure activity after chemical challenge. PMID: 18657176
37. Semaphorin3F induces significant growth cone collapse of temporal, but not nasal, RGCs expressing high levels of Neuropilin-2. PMID: 18942144
38. Soluble neuropilin-2 has no antirepellent activity but aggravates sympathetic nerve fiber repulsion and arthritis. Increased shedding of neuropilin-2 is probably an unfavorable sign in rheumatoid arthritis. PMID: 19790074
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亞細胞定位：

Membrane; Single-pass type I membrane protein.
蛋白家族：

Neuropilin family
組織特異性：

Expressed in developing CNS, PNS and in some nonneural tissues including limb buds, developing bones, muscles, intestinal epithelium, kidney, lung and submandibular gland.
數據庫鏈接：

KEGG: mmu:18187

STRING: 10090.ENSMUSP00000109794

UniGene: Mm.266341