Recombinant Mouse Neuritin (Nrn1)

^{In
Stock}

中文名稱：

小鼠Nrn1重組蛋白
貨號：

CSB-EP807503MO
說明書：

MSDS Datasheet
規格：

￥1836
圖片：
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

Greater than 95% as determined by SDS-PAGE.
生物活性：

Not Test
基因名：

Nrn1
Uniprot No.：

Q8CFV4
別名：

(Candidate plasticity gene 15 protein)
種屬：

Mus musculus (Mouse)
蛋白長度：

Full Length of Mature Protein
來源：

E.coli
分子量：

17.4
表達區域：

28-116aa
氨基酸序列

AGKCDAVFKGFSDCLLKLGDSMANYPQGLDDKTNIKTVCTYWEDFHSCTVTALTDCQEGAKDMWDKLRKESKNLNIQGSLFELCGSSNG
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 10xHis-tagged and C-terminal Myc-tagged
產品提供形式：

Liquid or Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

3-7 business days
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells.
基因功能參考文獻：
1. Following cerebral ischemia there is an increase in cpg15 expression in hippocampal astrocytes. PMID: 28069924
2. Ca(2+)/calcineurin (CaN)/nuclear factor of activated T-cells (NFAT) c4 axis is required for neuritin-induced Kv4.2 transcriptional expression and potentiation of IA densities in cerebellum granule neurons. PMID: 27307045
3. Neuritin prevents extremely low-frequency electromagnetic fields-exposure-induced memory deficit by increasing the hippocampal spine density. PMID: 26138388
4. Neuritin can normalize neural deficits of Alzheimer's disease. PMID: 25393479
5. Neuritin restors the reduction in dendritic spine density and the maturity of individual spines in primary hippocampal neuron cultures from a Alzheimer disease mouse model. PMID: 25101829
6. Activity-dependent development of the visual system requires synapse stabilization and maturation via CPG15. PMID: 24599452
7. CPG15 acts to stabilize active synapses on dendritic spines, resulting in selective spine and arbor stabilization and synaptic maturation, and that synapse stabilization mediated by CPG15 is critical for efficient learning PMID: 22190461
8. Data show that SMN and HuD form a complex in spinal motor axons, and that both interact with cpg15 mRNA in neurons. PMID: 21652774
9. Cpg15 is an immediate-early gene induced by Ca(2+) influx through NMDA receptors and L-type voltage-sensitive calcium channels. It requires convergent activation of the CaM kinase and MAP kinase pathways. PMID: 14664806
10. Regulation of cpg15 expression during single whisker experience in the barrel cortex of adult mice. PMID: 16010668
11. Data show that neuritin expression is well correlated to the maturation of hepatocytes and can be a useful tool to define the differentiation stage of hepatocytes. PMID: 16081067
12. CPG15 may function as a new factor required in re-establishment of neuronal network after the injury. PMID: 17439354
13. CPG15 and CPG15-2 perform similar cellular functions but may play distinct roles in vivo through their cell-type- and tissue-specific transcriptional regulation PMID: 18265009
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亞細胞定位：

Cell membrane; Lipid-anchor, GPI-anchor. Cell junction, synapse.
蛋白家族：

Neuritin family
組織特異性：

Expressed in the brain (at protein level).
數據庫鏈接：

KEGG: mmu:68404

STRING: 10090.ENSMUSP00000040900

UniGene: Mm.232930