Recombinant Mouse Myristoylated alanine-rich C-kinase substrate (Marcks)
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中文名稱：小鼠Marcks重組蛋白
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貨號：CSB-EP013493MO-B
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說明書：
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規格：
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來源：E.coli
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共軛：Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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其他：
產品詳情
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純度：>85% (SDS-PAGE)
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基因名：
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Uniprot No.：
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別名：Marcks; MacsMyristoylated alanine-rich C-kinase substrate; MARCKS
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種屬：Mus musculus (Mouse)
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蛋白長度：Full Length of Mature Protein
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表達區域：2-309
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氨基酸序列GAQFSKTAA KGEATAERPG EAAVASSPSK ANGQENGHVK VNGDASPAAA EPGAKEELQA NGSAPAADKE EPASGSAATP AAAEKDEAAA ATEPGAGAAD KEAAEAEPAE PSSPAAEAEG ASASSTSSPK AEDGAAPSPS SETPKKKKKR FSFKKSFKLS GFSFKKSKKE SGEGAEAEGA TAEGAKDEAA AAAGGEGAAA PGEQAGGAGA EGAAGGEPRE AEAAEPEQPE QPEQPAAEEP QAEEQSEAAG EKAEEPAPGA TAGDASSAAG PEQEAPAATD EAAASAAPAA SPEPQPECSP EAPPAPTAE
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蛋白標簽：Tag?type?will?be?determined?during?the?manufacturing?process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially. -
產品提供形式：Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand. -
復溶：We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
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儲存條件：Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
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保質期：The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. -
貨期：Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
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注意事項：Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Datasheet ：Please contact us to get it.
產品評價
相關產品
靶點詳情
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功能：MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein.
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基因功能參考文獻：
- this work establishes a novel role for MARCKS in axon dynamics and highlights the necessity of MARCKS as an organizer of DCC signaling at the membrane. PMID: 29546593
- Strongly support the existence of a PKC-MARCKS-PI3K regulatory module. PMID: 29715315
- ENaC activity is regulated by calpain-2 proteolysis of MARCKS. PMID: 28468944
- In the absence of Pin1, MARCKS is hyper-phosphorylated, leading to loss of cell adhesions, and collapse of the growth cone. PMID: 26991250
- Findings suggest that MIR429 modulates mucin secretion in human colorectal cells and mouse colitis tissues by up-regulating of MARCKS expression. PMID: 26818658
- Conditional deletion of MARCKS in ECs induces intracellular accumulation of mucins, elevated oxidative stress, and lipid droplet buildup. PMID: 26010231
- MARCKS acts as a "molecular switch," binding to and regulating PIP2 signaling to regulate processes like proplatelet extension (microtubule-driven) vs proplatelet branching (Arp2/3 and actin polymerization-driven). PMID: 26744461
- MARCKS knockdown arrested VSMC cell cycle by decreasing KIS expression. Decreased KIS expression resulted in nuclear trapping of p27kip1 in VSMCs. PMID: 26528715
- MARCKS regulates the expression of proinflammatory cytokines in macrophages through activation of p38/JNK MAPK and NF-kappaB. PMID: 25929183
- Targeting phospho-MARCKS overcomes drug-resistance and induces antitumor activity in preclinical models of multiple myeloma. PMID: 25179733
- Grin 1 is identified as a novel Cdk5 substrate and MARCKS is confirmed as a Cdk5 substrate. PMID: 24658276
- MARCKS appears to be a nonessential regulatory protein in mast cell exocytosis but exerts a negative modulation. PMID: 24705720
- MARCKS overexpression in the hippocampus of old mice leads to long-term potentiation and improved memory. PMID: 23434911
- an important functional role for the interaction between MARCKS and PSA in the developing and adult nervous system. PMID: 23329829
- cathepsin K exocytosis is controlled by PKCdelta through modulation of the actin bundling protein myristoylated alanine-rich C-kinase substrate. PMID: 22806935
- These results suggest that MARCKS is involved in directed migration of macrophages PMID: 22623357
- a critical role for H(2)O(2) in angiotensin-II signaling to the endothelial cytoskeleton in a novel pathway that is critically dependent on MARCKS, Rac1, and c-Abl. PMID: 22773836
- the capacity of MARCKS-ED to regulate granule exocytosis in a PKC-dependent manner, consistent with regulated sequestration of phosphoinositides that mediate granule fusion at the plasma membrane. PMID: 22013076
- MARCKS contributes to the negative regulation of the cellular response to LPS. PMID: 22427633
- L-PGDS protein regulates glial cell migration and morphology through Marcks in prostaglandin D2 independent manner. PMID: 22275363
- findings suggest that abnormal expression of MARCKS via dysfunction of Dysbindin might cause impairment of neural transmission and abnormal synaptogenesis PMID: 20098743
- Motif analyses revealed ca. 12 overlapping potential transcription factor binding sites; synergistic interaction between distal and proximal promoter sequences is indispensable for the optimal MARCKS promoter function PMID: 11944910
- Sequential activation of individual PKC isozymes in integrin-mediated muscle cell spreading: a role for MARCKS in an integrin signaling pathway. PMID: 11973356
- Hippocampal, total MARCKS mRNA and protein levels in C57BL/6J mice were significantly lower compared with DBA/2J mice; Restraint stress resulted in significant reduction in membrane MARCKS expression in C57BL/6J hippocampus but not for DBA/2J mice PMID: 12675922
- post-translational modifications of MARCKS are necessary and sufficient to regulate actin-binding activity PMID: 15640140
- Results show that phosphorylated MARCKS is a novel centrosome component and also defines a previously unrecognized subdomain of the actin cap overlying the spindle. PMID: 15766745
- Antisense strategy directed against MARCKS, a calpain substrate during C2C12 migration, showed that this protein could play a role in stress fiber polymerization. PMID: 16496301
- Increased cleavage of MARCKS in brain and macrophages, but not in liver and kidney extracts of stefin B-deficient mice compared to wild-type mice, was observed. PMID: 17655504
- Data demonstrate in mice that the myristoylated alanine-rich C-kinase substrate protein (MARCKS), a prominent cellular substrate for PKC, modulates radial glial placement and expansion. PMID: 19666823
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亞細胞定位：Cytoplasm, cytoskeleton. Membrane; Lipid-anchor.
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蛋白家族：MARCKS family
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組織特異性：Brain, spleen, less in kidney and heart, and very low levels in liver.
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