Recombinant Mouse MOB kinase activator 1B (Mob1b)

中文名稱：

小鼠Mob1b重組蛋白
貨號：

CSB-YP806414MO
規(guī)格：
來源：

Yeast
其他：

中文名稱：

小鼠Mob1b重組蛋白
貨號：

CSB-EP806414MO
規(guī)格：
來源：

E.coli
其他：

中文名稱：

小鼠Mob1b重組蛋白
貨號：

CSB-EP806414MO-B
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Mob1b重組蛋白
貨號：

CSB-BP806414MO
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Mob1b重組蛋白
貨號：

CSB-MP806414MO
規(guī)格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Mob1b
Uniprot No.：

Q8BPB0
別名：

Mob1b; Mobkl1a; MOB kinase activator 1B; Mob1 homolog 1A; Mps one binder kinase activator-like 1A
種屬：

Mus musculus (Mouse)
蛋白長度：

Full Length of Mature Protein
表達區(qū)域：

2-216
氨基酸序列

SFLFGSRSS KTFKPKKNIP EGSHQYELLK HAEATLGSGN LRMAVMLPEG EDLNEWVAVN TVDFFNQINM LYGTITDFCT EESCPVMSAG PKYEYHWADG TNIKKPIKCS APKYIDYLMT WVQDQLDDET LFPSKIGVPF PKNFMSVAKT ILKRLFRVYA HIYHQHFDPV IQLQEEAHLN TSFKHFIFFV QEFNLIDRRE LAPLQELIEK LTSKDR
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L.
基因功能參考文獻：
1. MOB1A and MOB1B have overlapping functions in skin homeostasis, and exert their roles as tumor suppressors by regulating downstream elements of the Hippo pathway. PMID: 23143302
2. MOBKL1A/MOBKL1B phosphorylation, by MST1 and MST2, is sufficient to inhibit proliferation through actions at several points in the cell cycle. PMID: 18328708
3. Mst1/2-catalyzed MOBKL1A/B phosphorylation slows proliferation and is therefore a likely contributor to the anti-proliferative action of Mst1 in naive T cells PMID: 19073936
亞細胞定位：

Cytoplasm. Nucleus.
蛋白家族：

MOB1/phocein family
數據庫鏈接：

KEGG: mmu:68473

STRING: 10090.ENSMUSP00000006424

UniGene: Mm.35764