Recombinant Mouse LIM/homeobox protein Lhx1 (Lhx1)

中文名稱：

小鼠Lhx1重組蛋白
貨號(hào)：

CSB-YP012919MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

小鼠Lhx1重組蛋白
貨號(hào)：

CSB-EP012919MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
其他：

中文名稱：

小鼠Lhx1重組蛋白
貨號(hào)：

CSB-EP012919MO-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Lhx1重組蛋白
貨號(hào)：

CSB-BP012919MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Lhx1重組蛋白
貨號(hào)：

CSB-MP012919MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Lhx1
Uniprot No.：

P63006
別名：

Lhx1; Lim-1; Lim1LIM/homeobox protein Lhx1; LIM homeobox protein 1; Homeobox protein Lim-1
種屬：

Mus musculus (Mouse)
蛋白長度：

Full length protein
表達(dá)區(qū)域：

1-406
氨基酸序列

MVHCAGCKRP ILDRFLLNVL DRAWHVKCVQ CCECKCNLTE KCFSREGKLY CKNDFFRCFG TKCAGCAQGI SPSDLVRRAR SKVFHLNCFT CMMCNKQLST GEELYIIDEN KFVCKEDYLS NSSVAKENSL HSATTGSDPS LSPDSQDPSQ DDAKDSESAN VSDKEGGSNE NDDQNLGAKR RGPRTTIKAK QLETLKAAFA ATPKPTRHIR EQLAQETGLN MRVIQVWFQN RRSKERRMKQ LSALGARRHA FFRSPRRMRP LVDRLEPGEL IPNGPFSFYG DYQSEYYGPG GNYDFFPQGP PSSQAQTPVD LPFVPSSGPS GTPLGGLDHP LPGHHPSSEA QRFTDILAHP PGDSPSPEPS LPGPLHSMSA EVFGPSPPFS SLSVNGGASY GNHLSHPPEM NEAAVW
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis.
基因功能參考文獻(xiàn)：
1. Findings suggest that Lhx1/5, through regulating Espin protein expression, control dendritogenesis and spine morphogenesis in postnatal Purkinje cells (PCs). PMID: 28516904
2. Loss of LHX1 is associated with loss of acute light control of sleep. PMID: 28017605
3. Smad4/Eomes-dependent Lhx1 expression in the epiblast marks the entire definitive endoderm lineage, the anterior mesendoderm, and midline progenitors. PMID: 26494787
4. LHX1 is required in the anterior mesendoderm, but not in the mesoderm, for formation of the head. PMID: 25977363
5. Lhx1 maintains synchrony among circadian oscillator neurons of the suprachiasmatic nucleus. PMID: 25035422
6. Lhx1 is necessary for SCN terminal differentiation, including expression of neuropeptides profoundly important for circadian function. PMID: 24767996
7. OTX2 has a role in regulating Dkk1 and Lhx1 activity in the anterior mesendoderm PMID: 25231759
8. These studies identify LHX1 as the first transcription factor that is essential in the Mullerian duct epithelial progenitor cells for female reproductive tract development. PMID: 24560999
9. a core regulatory subcircuit composed of Pax2/8, Gata3 and Lim1 turns on a deeper layer of transcriptional regulators while activating effector genes responsible for cell signaling and tissue organization. PMID: 23920117
10. Lim1/LIM1 expression in neonatal, adult mouse and human endometrium suggesting Lim1/LIM1 may have a role in endometrial development and remodelling PMID: 22231913
11. Lhx1 therefore may influence the localization of primordial germ cells by modulating Ifitm1-mediated repulsive activity. PMID: 20845430
12. The response of LMC motor neurons to Reelin is gated by Foxp1- and Lhx1-mediated regulation of expression of the critical Reelin signalling intermediate Dab1. PMID: 20711475
13. Conserved requirement of Lim1 function for cell movements during gastrulation PMID: 12530965
14. LIM homeodomain proteins establish motor neuron topography by coordinating the mediolateral settling position of motor neurons within the LMC with the dorsoventral selection of axon pathways in the limb. PMID: 12765610
15. Lim1 has essential roles in multiple steps of epithelial tubular morphogenesis during kidney organogenesis PMID: 15930111
16. Lim 1 influences nephric duct extension and ureteric bud outgrowth by regulating and or maintaining the differentiation of the nephric epithelium. PMID: 16216236
17. Lhx1 and Lhx5 function together with Pax2, Pax5 and Pax8 to establish a GABAergic inhibitory-neurotransmitter program in dorsal horn interneurons. PMID: 17166926
18. GDNF up-regulation of Bcl6b, Erm, and Lhx1 expression through Src family kinase signaling is a key component of the intracellular mechanism for spermatogonial stem cells self-renewal. PMID: 17597063
19. Lim1 lies downstream of horizontal cell fate determination factors and functions in a cell-autonomous manner to instruct differentiating horizontal cells to the appropriate laminar position in the developing retina. PMID: 18094249
20. Data show that Lhx1 is regionally enriched in the Cerebellum, Purkinje Cell Layer of mouse brain. PMID: 18625066
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亞細(xì)胞定位：

Nucleus.
組織特異性：

In mid to late stage embryos, expressed in a restricted region of mesoderm in the primitive streak. At 7.5 days, expressed in a horseshoe shape at the periphery of the node, as well as along both sides of the adjacent notochord. Also present in presumptiv
數(shù)據(jù)庫鏈接：

KEGG: mmu:16869

STRING: 10090.ENSMUSP00000018842

UniGene: Mm.4965