1. Study in a mouse model of collagen-induced arthritis identified the integrin alpha2 gene (Itga2) as an additional and novel biomarker for rheumatoid arthritis. PMID: 29333090
2. P15 does not directly activate integrins by binding, but does upregulate integrin signaling to enhance differentiation of both osteoblasts and chondrocytes to increase both intramembranous and endochondral bone formation. PMID: 28389839
3. low expression of alpha2beta1 integrin increased protein kinase B (AKT) activation and alpha-smooth muscle actin (alpha-SMA) expression. This occurred due to the instability of phosphatase and tensin homolog (PTEN) in myofibroblasts on fibrillar collagen. PMID: 28251149
4. A sulfonamide-type small-molecule inhibitor of alpha2beta1 integrin decreased average platelet adhesion in individuals with the C/T807T genotype but not in those harboring C807C. PMID: 26556301
5. Ceacam1 is essential for normal integrin aIIbb3-mediated platelet function; the disruption of mouse Ceacam1 induced moderate integrin aIIbb3-mediated functional defects. PMID: 26196244
6. HRG binds to alpha2 integrin through low-affinity interactions in a heparin sulfate-independent manner, thereby blocking endothelial cells adhesion to collagen I. PMID: 26051322
7. LG3, through interactions with alpha2beta1 integrins on recipient-derived cells leading to activation of ERK1/2 and increased migration, favors myointimal thickening PMID: 25808553
8. IFN-gamma induces aberrant CD49b+ NK cell recruitment and pregnancy failure through regulating CX3CL1. PMID: 25375377
9. alphaIIbbeta3 regulates Syk through an ITAM-independent pathway in mice and provide novel insight into the course of events underlying Syk activation and hemITAM phosphorylation by CLEC-2 PMID: 25352128
10. the collagen receptors DDR1 and integrin a2b1 contribute to regulate GBM-maturation and to control matrix accumulation. PMID: 24480069
11. Synthesis and modeling of linear and cyclic KTS-containing peptides is described that leads to their use as inhibitors of integrin alpha1beta1/alpha2beta1-mediated adhesion and other antiangiogenetic activity in human serum. PMID: 24939421
12. alpha2beta1 integrin contributes to the pathogenesis of retinopathy. We describe a newly identified role for alpha2beta1 integrin in mediating hypoxia-induced Muller cell VEGF-A production. PMID: 24917135
13. Integrin alpha2 in induced pluripotent stem cells mediates their differentiation into odontoblast-like cells. PMID: 24244598
14. required for the migration of memory CD4 T-cell precursors into their survival niches of the bone marrow PMID: 23897120
15. alpha2beta1 integrin is expressed on synovial Th17 cells from CIA mice. Its neutralization reduced inflammation, cartilage degradation, bone erosion, RANKL & IL-17 levels, & the numbers of osteoclasts and TH17 cells. PMID: 24244022
16. the absence of integrin alpha2beta1 alleviates the effects of age related bone degradation through over-expression of collagen type I. PMID: 23680479
17. TNF-alpha stimulated cerebral pericyte remodeling in an alpha2 integrin-dependent manner. PMID: 23448258
18. observed a significant reduction in mean platelet volume, which is consistent with the reported role of alpha2beta1 in MK maturation and proplatelet formation in vivo PMID: 23359821
19. Blocking integrin alpha2beta1 and ERK 1/2 pathways alleviated the effects of AMBN on osteoclast differentiation. PMID: 23385480
20. Expression of integrin alpha2 receptor in human cord blood CD34+CD38-CD90+ stem cells determines its long-term engrafting in NOD/SCID-IL2Rgamma(c) null mice. PMID: 23165626
21. These data show for the first time that decorin has an impact on the biology of alpha2beta1 integrin and the vimentin intermediate filament system. PMID: 23226541
22. beta-arr1 has a role in promoting thrombus formation, in part through its participation in alphaIIbbeta3 signalling, but neither beta-arr1 or beta-arr2 have a role in agonist-induced platelet activation and P2Y receptors desensitisation PMID: 22318609
23. The loss of alpha2betaA1 integrin suppresses joint inflammation and cartilage destruction in mouse models of rheumatoid arthritis. PMID: 22083543
24. ADAP plays a role in mediating platelet activation via the collagen-binding integrin alpha(2) beta(1). PMID: 22103309
25. Circulating IGF-1 levels in the sera of mice lacking either alpha2beta1 or alpha11beta1 or both integrins were sharply reduced. PMID: 22210772
26. alpha2beta1 integrin expression by HPV-transformed keratinocytes modulates squamous carcinoma growth and progression PMID: 22046385
27. show that PilA binds collagen, which promotes GBS interaction with the alphabeta integrin resulting in activation of host chemokine expression and neutrophil recruitment during infection PMID: 21897373
28. Suggest that the recruitment of peripheral CXCR4-expressing ITGA2(+)ISG20(+) NK cells into pregnant uteri may be important in the regulation of feto-maternal tolerance. PMID: 19321657
29. Collagen I stimulates the self-renewal of embryonic stem cells mediated by Bmi-1 through alpha2beta1 integrin-dependent ILK, Notch, Gli-1, and DDR1-dependent Ras, PI3K/Akt, and ERK. PMID: 21344393
30. PHLDA1 expression marks the putative epithelial stem cells, downregulates ITGA2 and ITGA6, and contributes to intestinal tumorigenesis PMID: 21558389
31. Results suggest a novel mechanism for pathogen entry into host cells as well as a new function for C1q- alpha2beta1 integrin interactions. PMID: 21134100
32. alpha2beta1 integrin suppresses metastasis in a clinically relevant spontaneous mouse model of breast cancer PMID: 21135504
33. transgenic mice have altered keratinocyte differentiation and proliferation, which results in chronic immune cell activation PMID: 19840869
34. enhance adhesion through alpha2beta1 integrin to collagens via a PLC-dependent priming mechanism. PMID: 19815553
35. MMP7 shedding of syndecan-1 facilitates wound closure by causing the alpha(2)beta(1) integrin to assume a less active conformation thereby removing restrictions to migration PMID: 19668337
36. Integrin alpha2beta1 is required for endorepellin induction of tyrosine phosphatase activity. PMID: 19789387
37. Integrin alpha 2 is rapidly induced and expressed on effector CD8+ T cells; its blockade inhibits adoptive transfer of antigen-specific delayed-type hypersensitivity responses. PMID: 12960301
38. that alpha 2 beta 1 integrin provides a costimulatory function required for mast cell activation and cytokine production in response to infection. PMID: 14645004
39. platelet aggregation response to collagen correlates with alpha(2) expression; alpha(2)beta(1) participates in signaling during platelet activation PMID: 14739220
40. VEGF-A induced alpha1 & alpha2 integrins, promoting lymphatic endothelial tube formation & haptotactic migration. Lineage-specific integrin receptor expression contribute to the distinct dynamics of wound-associated angiogenesis & lymphangiogenesis. PMID: 15132990
41. The distribution of GPIa (C807T/G873A) and HPA-3 genotypes did not differ significantly between normal subjects and coronary artery disease subjects PMID: 15227729
42. studies establish platelet-collagen responses under physiologic flow as the consequence of a close partnership between 2 structurally distinct receptors, glycoprotein VI and integrin alpha2beta1 PMID: 15886326
43. alpha2beta1 integrin is a novel receptor for multiple collectins and the C1q complement protein PMID: 16166590
44. high level expression of alpha2 selectively marks a subset of primitive hematopoietic cells which retains multilineage reconstitution potential but exhibits reduced self-renewal capacity PMID: 16373693
45. decreased surface alpha2beta1 results from decreased Itga2 pre-mRNA splicing regulated by hnRNP L and depends on CA repeat length at a specific site in intron 1 PMID: 16455949
46. Results describe the role of alpha2beta1 integrin in the interactions of primary fibroblasts and keratinocytes with the extracellular matrix. PMID: 16636073
47. Although the inflammatory properties of the CD49b-expressing subset of memory T helper cells are protective against intracellular bacterial infection, they are associated with immunopathology in acute viral infection. PMID: 16818752
48. extracellular matrix fragments produced by apoptotic EC initiate a state of resistance to apoptosis in fibroblasts via an alpha2beta1 integrin/SFK (Src and Fyn)/phosphatidylinositol 3-kinase (PI3K)-dependent pathway PMID: 16882656
49. Ablation of alpha2beta1 resulted in strong enhancement of neovascularization of granulation tissue and sponge implants. Alpha2beta1-null fibroblasts are hampered in generating mechanical forces. PMID: 16977325
50. Integrins may play an important role in lamellipodia formation. PMID: 17032352

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KEGG: mmu:16398

STRING: 10090.ENSMUSP00000053891

UniGene: Mm.5007