1. Mouse cardiac progenitor cells fate transitions are associated with distinct open chromatin states critically depending on Isl1 and Nkx2-5 expression. PMID: 30451828
2. ISL1 is a major susceptibility gene for bladder exstrophy and a regulator of urinary tract development. PMID: 28176844
3. ISL1 plays a central role in proper patterning of stem cell-derived enamel in the incisor and indicate that this factor is an important upstream regulator of signaling pathways during tooth development and renewal. PMID: 28650075
4. Both ISL1-LHX3 and ISL1-LHX4 bound to the Slit2 enhancer. PMID: 27819291
5. results support a model in which Gata6 contributes to repression of Isl1 expression in the anterior of nascent hindlimb buds. PMID: 29197504
6. The results demonstrated that Islet1 upregulated expression of general control of amino acid biosynthesis protein 5 (Gcn5) and enhanced the binding of Gcn5 to the promoters of GATA binding protein 4 (GATA4) and NK2 homeobox 5 (Nkx2.5). In addition, Islet-1 downregulated DNA methyltransferase (DNMT)1 expression and reduced its binding to the GATA4 promoter. PMID: 28447752
7. Isl1beta is a key additional transcriptional factor for advancing the generation of insulin-producing cells in the liver in combination with PDA (Pdx1, Neurod1, and Mafa). PMID: 29220426
8. Overexpression of Islet1 affects the development and function of the cerebello-vestibular system, resulting in hyperactivity. PMID: 26843111
9. Results show that specific genomic loci associated with Islet-1 (Isl1) , LIM-homeobox 3 (Lhx3), and LMO4 genes recruit the Isl1-Lhx3 complex to activate the transcription of Isl1, Lhx3, and Lmo4. PMID: 28451636
10. these results uncover a novel role for VEGF in controlling proper allocation of Isl1(+) cardiac progenitors to their respective descending lineages PMID: 27794491
11. CITED2 and ISL1 proteins interact physically and cooperate to promote embryonic stem cell differentiation toward cardiomyocytes. PMID: 27818139
12. Together, the authors show the antagonistic regulation of the alpha-enhancer activity by Pax6 and the LIM protein complex is necessary for the establishment of an inner retinal circuitry, which controls visual adaptation. PMID: 28139974
13. results identify Isl1 as a crucial transcription factor that plays essential roles in the gene regulatory program directing development of multiple arcuate neuronal subpopulations. PMID: 27578785
14. Expression of motor neuron effector genes is maintained by transient enhancers bound by Isl1/Lhx3 in nascent motor neurons and Isl1/Onecut1 in maturing hypaxial motor neurons. PMID: 27939581
15. These data reveal functional roles for an ISLET1-dependent network integrating beta-catenin/SHH signals in mesenchymal cell survival and outgrowth of the mandible during development. PMID: 28069742
16. ISL1 and JMJD3 partner to alter the cardiac epigenome, instructing gene expression changes that drive cardiac differentiation. PMID: 27105846
17. Pax2-regulated ISL1 overexpression increases the embryonic ISL1(+) domain and induces accelerated nerve fiber extension and branching in E12.5 embryos. PMID: 25990412
18. These results show that ISL1 is necessary for maximal thyrotrope response to hypothyroidism, in addition to its role in development of Rathke's pouch. PMID: 26296153
19. the Isl1/Ldb1 complex orchestrates a network for heart-specific transcriptional regulation and coordination in three-dimensional space during cardiogenesis. PMID: 26321200
20. All E1 sequences from lamprey to mouse responded equally well to Phox2a and the Isl1-Lhx3 complex. Conversely, E2, the enhancer for limb-innervating motor neurons, was only found in tetrapod animals PMID: 26447474
21. Isl1 alternative splicing varies across different retinal cell types. Two isoforms of Isl1 differ functionally as transcriptional activators. PMID: 25752730
22. this study gives new insights into transcriptional regulating mechanisms of Wnt-mediated Isl1 expression during cardiomyocyte differentiation. PMID: 24610003
23. results demonstrate that ISL1 regulates approximately one-third of SAN-specific genes, indicate that a combination of ISL1 and other SAN transcription factors could be utilized to generate pacemaker cells PMID: 26193633
24. lack both Isl1 and Isl2, large numbers of motor neurons exited the neural tube, even prior to the appearance of boundary cap cells at the ventral exit points PMID: 25843547
25. Data indicate that LIM-homeodomain transcription factor Islet 1 is necessary for hypothalamic proopiomelanocortin gene (Pomc) expression during embryogenesis. PMID: 25825735
26. Pou4f2 and Isl1, are sufficient to specify the retinal ganglion cell fate in ATOH7 deficient mice PMID: 25775587
27. The transcription factor Islet-1 is a positive transcriptional regulator of the cardiac pacemaker cell gene expression program in the developing sinoatrial node. PMID: 25623957
28. KISS-54 influences Isl-1 expression and insulin secretion through the protein kinase C-ERK1/2 pathway. PMID: 24956377
29. The transcription factors Sox2 and Isl1 physically interact and cooperatively function to sustain Atoh1 expression in developing Merkel cells. PMID: 25468937
30. Study demonstrates a sequential expression order of NEUROD1>ISL1>POU4F1>POU4F2 during the inner ear neurogenesis. PMID: 24709358
31. Expression pattern of Isl1 and its co-factor Ldb1, were analyzed in small intestine. PMID: 24755910
32. Isl-1 is essential for postnatal beta-cell function, directly regulates Pdx1 and Slc2a2, and has a mature beta-cell cistrome distinct from that of pancreatic endocrine progenitors. PMID: 25028525
33. Isl1 is required for the specification of a subset of enteroendocrine cells leading to lipid malabsorption in neonatal mice and the loss of the incretin response in adults. PMID: 25214396
34. Isl1 and Pou4f2 form a complex to regulate target genes in developing retinal ganglion cells. PMID: 24643061
35. Results suggest that ISL1 is intimately involved in early regulation of adipogenesis, modulating PPARgamma expression and activity via BMP4-dependent and -independent mechanisms. PMID: 25047837
36. This study demonstrates that the Isl1-Gata3 transcription regulatory axis is essential for normal pyloric development. PMID: 24674670
37. ISL1 is expresseed in multiple tissues during mouse development. PMID: 23906961
38. The data suggested that Islet-1 might function as an assistant factor that was involved in the regulation of histone acetylation and Mef2c expression via assisting p300 on specifically targeting the promoter of Mef2c. PMID: 24147056
39. the Isl1-beta-catenin pathway regulates skeletal development of the hindlimb and lower jaw through discrete populations of cells that give rise to Shh-expressing posterior hindlimb mesenchyme and Fgf8-expressing mandibular epithelium. PMID: 24424161
40. Islet-1 has a role in promoting striatonigral and repressing striatopallidal genetic programs to specify striatonigral cell identity PMID: 24351932
41. Conditional inactivation of Isl1 in the telencephalon resulted in a smaller striatum with fewer striatonigral neurons and reduced projections to the substantia nigra. PMID: 24082127
42. This study demonistrated that hair cell-specific Isl1 expression can promote hair cell survival and therefore minimize the hearing impairment that normally occurs with aging and/or acoustic overexposure. PMID: 24048839
43. Data characterized an intramolecular interaction between the LIM domains and LIM homeobox 3 (Lhx3)-binding domain in Isl1. PMID: 23750000
44. Isl1 is essential for proper development of the kidney and ureter by repressing the aberrant formation of the ureteric bud PMID: 23641053
45. In Islet-1 deficient mouse embryos the numbers of chromaffin cells were only mildly reduced, in contrast to that of sympathetic neurons PMID: 23648511
46. Our findings demonstrate a novel epistatic relationship between Shox2 and Isl1 in the heart with important developmental consequences for sinoatrial node formation and heart beat. PMID: 23455426
47. LIM-homeodomain transcription factor Isl-1 mediates the effect of leptin on insulin secretion in mice. PMID: 23504315
48. spinal microcircuits that integrate cutaneous feedback crucial for paw grip rely on the intermediary role of isl1 expression interneurons. PMID: 23583114
49. Isl1 and the Ldb co-regulators of transcription are essential early determinants of mouse limb development PMID: 22411555
50. Data suggest that Ldb1 is critical transcriptional coregulator during pancreatic islet alpha-, beta-, and delta-cell development through Isl1-dependent and potentially Isl1-independent control mechanisms. PMID: 23193182

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KEGG: mmu:16392

STRING: 10090.ENSMUSP00000044879

UniGene: Mm.42242