Recombinant Mouse Inhibin alpha chain (Inha)

中文名稱：

小鼠Inha重組蛋白
貨號：

CSB-YP011718MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Inha重組蛋白
貨號：

CSB-EP011718MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Inha重組蛋白
貨號：

CSB-EP011718MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Inha重組蛋白
貨號：

CSB-BP011718MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Inha重組蛋白
貨號：

CSB-MP011718MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Inha
Uniprot No.：

Q04997
別名：

Inha; Inhibin alpha chain
種屬：

Mus musculus (Mouse)
蛋白長度：

Full Length of Mature Protein
表達區域：

234-366
氨基酸序列

STPSVPW PWSPAALRLL QRPPEEPAAH AFCHRAALNI SFQELGWDRW IVHPPSFIFH YCHGSCGMPT SDLPLPVPGV PPTPVQPLFL VPGAKPCCAA LPGSMRSLRV RTTSDGGYSF KYEMVPNLIT QHCACI
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. Inhibin deficient mice are viable but are acutely sensitive to development of gonadal sex-cord stromal tumors.
基因功能參考文獻：
1. These data suggest that activin-follistatin regulation may play a role during the development of Experimental autoimmune epididymo-orchitis. PMID: 28205525
2. This study tested the hypothesis that inhibins act in an autocrine manner on Leydig cells using a pre-pubertal Leydig cell line, TM3, as a model of immature Leydig cells. PMID: 27465829
3. The study is the first to identify an intratesticular role for inhibin/inhibin-alpha subunit, demonstrating that a threshold level of this protein is required for normal testis development and to sustain adult somatic testicular cell function. PMID: 25781564
4. inhibin is a broad regulatory marker in anterior pituitary cells PMID: 24098340
5. A novel role for GDF9 in causing reproductive defects and suppressing tumor initiation in the Inha(-/-) mouse model. PMID: 23446452
6. Data indicate that the inhibin-alpha promoter is activated synergistically by Wt1 and Sf1. PMID: 23326390
7. Inhibin alpha-subunit N terminus interacts with activin type IB receptor to disrupt activin signaling. PMID: 22267736
8. relationship between inhibin and Sertoli cell activity PMID: 21998670
9. These data support the role of proconvertase PCSK5 in the processing of ovarian inhibin subunits during folliculogenesis. PMID: 21408162
10. There are widespread alterations in the transcriptome of gonadotropin-treated Inha-/- granulosa cells, with significant changes in genes involved in extracellular matrix and cell-cell communication. PMID: 20739397
11. Results demonstrate that RB is not essential for Sertoli cell tumorigenesis in Inha KO mice but that loss of Inha accelerates the infertility phenotype of Rb cKO mice. PMID: 20676395
12. SMAD 2 is not required for mediating tumorigenic signals of activin in ovarian tumor development caused by loss of inhibin. PMID: 20565978
13. beta-catenin synergizes with steroidogenic factor-1 to activate the alpha-inhibin promoter through formation of a transcriptional complex PMID: 12732619
14. inhibin-alpha gene expression is developmentally regulated in the mouse testis PMID: 15055530
15. Transregulation of LH receptor (LHR) and transcription factor GATA-4, coexpressed during the adrenocortical tumorigenesis of prepubertally gonadectomized transgenic (TG) mice expressing the inhibin alpha-subunit PMID: 15256532
16. LRH-1 and SF-1 act similarly to increase promoter activity of inhibin alpha. PMID: 16423880
17. Activin A has opposite effects on glucagon and arx gene expression in alpha-cells compared with beta-cells, a finding that may have relevance during pancreatic endocrine lineage specification and physiological function of the adult islets PMID: 16988001
18. Gonadal InhA may be a component of the normal endocrine repertoire that regulates bone quality in both the axial and appendicular skeleton. PMID: 17194739
19. concurrent loss of Rb and inhibins in the ovary will exacerbate tumor formation PMID: 17510234
20. LH is not required for tumor formation in the absence of inhibins but promotes tumor progression, likely through alterations in serum hormone levels and cell cycle regulators. PMID: 18657590
21. The expression of inhibin isotypes increases progressively in the testis of mice with increasing postnatal age, suggesting that inhibin is associated with a negative feedback signal for FSH in testicular maturation. PMID: 19043308
22. analysis of inhibin alpha null mice uncovered a delay in early thymocyte development and decreased thymocyte numbers in vitro, supporting the role of activins and inhibins during T cell development in vivo. PMID: 19338778
23. These results demonstrated that endocrine effects of inhibin as a negative feedback controller of follicle stimulating hormone production in gonadotropes are dependent on betaglycan expression. PMID: 19524135
24. Absence of inhibin alpha resulted in advanced follicular maturation. Regulation of the inhibin/activin system is essential for early folliculogenesis in the prepubertal mouse ovary. PMID: 19666016
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亞細胞定位：

Secreted.
蛋白家族：

TGF-beta family
數據庫鏈接：

KEGG: mmu:16322

STRING: 10090.ENSMUSP00000040310

UniGene: Mm.1100