Recombinant Mouse Inactive rhomboid protein 2 (Rhbdf2), partial

中文名稱：

小鼠Rhbdf2重組蛋白
貨號：

CSB-YP772158MO
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Rhbdf2重組蛋白
貨號：

CSB-EP772158MO
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Rhbdf2重組蛋白
貨號：

CSB-EP772158MO-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Rhbdf2重組蛋白
貨號：

CSB-BP772158MO
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Rhbdf2重組蛋白
貨號：

CSB-MP772158MO
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Rhbdf2
Uniprot No.：

Q80WQ6
別名：

Rhbdf2; Irhom2; Rhbdl6; Rhor; Inactive rhomboid protein 2; iRhom2; Rhomboid family member 2; Rhomboid veinlet-like protein 6; Rhomboid-related protein
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own.
基因功能參考文獻：
1. These findings indicated that iRhom2 played an essential role in regulating particulate matter (PM2.5) -induced chronic renal damage, thus revealing a potential target for preventing chronic kidney diseases development. PMID: 30165303
2. iRHOM2 is a novel target gene of p63 and that both p63 and iRHOM2 differentially regulate cellular stress-associated signalling pathways in normal and hyperproliferative keratinocytes. PMID: 29523849
3. Study identified iRHOM2 as a novel regulator of K16 in humans and mice, with important implications for palmoplantar keratodermas, wound healing, inflammatory skin disease and cancers. PMID: 28128203
4. A tissue-specifc function of RHBDF2 rather than the surrounding microenvironment or the immune system underlies hyperproliferative skin disease. PMID: 29116018
5. iRhom2 controls multiple aspects of TACE biology, including stimulated shedding on the cell surface. PMID: 29045841
6. Overall, iRhom2 binds to TACE throughout its lifecycle, implying that iRhom2 is a primary regulator of stimulated cytokine and growth factor signalling. PMID: 28432785
7. long-term PM2.5 exposure caused hepatic steatosis and dyslipidemia through triggering inflammation, which was, at least partly, dependent on iRhom2/TNF-alpha pathway in liver-resident macrophages PMID: 28965953
8. baseline expression of genes acting within the NRF2 anti-oxidative pathway, followed by gene alterations associated with the integrin receptor aggregation pathway and the FcgammaR-mediated phagocytosis pathway, contribute to accelerated wound healing PMID: 28268192
9. the critical role of the transmembrane domains of ADAM17 and Rhbdf2 in the regulation of the ADAM17 and EGFR, and ADAM17 and TNFalpha signaling pathways, was examined. PMID: 28104813
10. this study shows that the iRhom2/ADAM17 pathway plays an important role in regulating CSF1R expression in the myeloid cell compartment at steady state, and in modulating development of monocytes/macrophages during their repopulation PMID: 27601030
11. this study shows that iRhom2-deficient mice were more susceptible to lethal herpes simplex virus type 1 infection, and that iRhom2 is essential for STING activity, as it regulates TRAPbeta-mediated translocation and EIF3S5-mediated deubiquitination of STING PMID: 27428826
12. This study identifies iRhom2 as a novel regulator for determination of keratinocyte lineages. PMID: 27393687
13. IRhom2 may be a promising therapeutic target for LPS-induced cardiac injury. PMID: 28033581
14. iRhom2 is required for the maturation of TACE and hair follicle differentiation. PMID: 25546423
15. a principal function of iRhoms1/2 during mouse development is to regulate ADAM17-dependent EGFR signaling PMID: 25918388
16. Rhbdf2 mutations increase its protein stability and drive EGFR hyperactivation through enhanced secretion of amphiregulin. PMID: 24825892
17. findings uncover functions for iRhom2 in the regulation of EGFR signaling and in controlling the activation and substrate selectivity of ADAM17-dependent shedding events PMID: 23801765
18. mice lacking Rhbdf2 were protected from K/BxN inflammatory arthritis to the same extent as mice lacking TACE in myeloid cells or Tnfa-deficient mice PMID: 23348744
19. These results establish a specific role for iRhom2 in the secretion of TNFalpha. PMID: 22550345
20. iRhom2 is required for TNF release; iRhom2 binds TACE and promotes its exit from the ER; failure of TACE to exit the ER in the absence of iRhom2 prevents the furin-mediated maturation and trafficking of TACE to the cell surface, the site of TNF cleavage PMID: 22246777
21. study reports iRhom2 interacted with TACE and regulated TNFalpha shedding; iRhom2 was critical for TACE maturation and trafficking to cell surface in hematopoietic cells; study identified iRhom2 as a regulator of innate immunity PMID: 22246778
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亞細胞定位：

Endoplasmic reticulum membrane; Multi-pass membrane protein.
蛋白家族：

Peptidase S54 family
數據庫鏈接：

KEGG: mmu:217344

STRING: 10090.ENSMUSP00000099317

UniGene: Mm.89695