Recombinant Mouse Immunoglobulin J chain (Jchain)

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中文名稱：

小鼠Jchain重組蛋白
品名簡稱：

Recombinant Mouse Jchain protein
貨號：

CSB-EP011337MO
說明書：

MSDS Datasheet
規格：

￥1836
圖片：
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
其他：

產品詳情
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靶點詳情

產品詳情

純度：

Greater than 90% as determined by SDS-PAGE.
基因名：

Jchain
Uniprot No.：

P01592
別名：

Jchain; IgjImmunoglobulin J chain
種屬：

Mus musculus (Mouse)
蛋白長度：

Full Length of Mature Protein
來源：

E.coli
分子量：

31.7kDa
表達區域：

22-159aa
氨基酸序列

GDDEATILADNKCMCTRVTSRIIPSTEDPNEDIVERNIRIVVPLNNRENISDPTSPLRRNFVYHLSDVCKKCDPVEVELEDQVVTATQSNICNEDDGVPETCYMYDRNKCYTTMVPLRYHGETKMVQAALTPDSCYPD
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 6xHis-SUMO-tagged
產品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

3-7 business days
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
產品描述：

CUSABIO synthesized the recombinant gene by integrating the N-terminal 6xHis-SUMO tag sequence into the targeted gene encoding the 22-159aa of the mouse Jchain. The synthesized gene was subsequently cloned into an expression vector. After cloning, the expression vector was introduced into the E.coli for expression. The product was purified to obtain the recombinant mouse Jchain protein carrying N-terminal 6xHis-SUMO tag. The SDS-PAGE assayed the purity of this recombinant Jchain protein greater than 90%. This Jchain protein migrated along the gel to a band of about 30 kDa molecular weight.
Immunoglobulin J chain is a protein encoding by a gene named Jchain in mouse and a gene named JCHAIN in human. This protein is a protein component of the antibodies IgM and IgA. The J chain-joined dimer is a nucleating unit for the IgM pentamer. And it induces dimers and/or larger polymers in the case of IgA. Moreover, it also helps to bind these immunoglobulins to secretory component. The diseases involved JCHAIN include Alpha Chain Disease and Climatic Droplet Keratopathy. Additionally, a study have reported that the upregulation of JCHAIN was likely related to tumor aggression, as studied in a cohort of patients with acute lymphoblastic leukemia (ALL).
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces dimers and/or larger polymers. It also helps to bind these immunoglobulins to secretory component.
基因功能參考文獻：
1. Data show that Crlz1 increased the IgJ enhancer activity due to its CBF sites, as verified by both the absence of Crlz1 effect on the CBF-site mutated IgJ enhancer and the presence of transcriptional synergy between Crlz1 and CBFbeta. PMID: 19735751
2. identifies the HSS3/4 enhancer of Crlz1-IgJ locus as another target of EBG in early developmental stage of B cells PMID: 16962668
3. H3 and H4 histones toward the chromatin of the Crlz1 gene are found to be hyperacetylated, especially on H3, in the pre-B cells, whereas those toward the chromatin of the IgJ gene are found to be hyperacetylated in the plasma cells PMID: 17015728
亞細胞定位：

Secreted.
數據庫鏈接：

KEGG: mmu:16069

STRING: 10090.ENSMUSP00000084259

UniGene: Mm.1192