Recombinant Mouse High mobility group protein HMGI-C (Hmga2)

中文名稱：

小鼠Hmga2重組蛋白
貨號：

CSB-YP010552MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Hmga2重組蛋白
貨號：

CSB-EP010552MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Hmga2重組蛋白
貨號：

CSB-EP010552MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Hmga2重組蛋白
貨號：

CSB-BP010552MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Hmga2重組蛋白
貨號：

CSB-MP010552MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Hmga2
Uniprot No.：

P52927
別名：

Hmga2; HmgicHigh mobility group protein HMGI-C; High mobility group AT-hook protein 2
種屬：

Mus musculus (Mouse)
蛋白長度：

Full Length of Mature Protein
表達區域：

2-108
氨基酸序列

SARGEGAGQ PSTSAQGQPA APVPQKRGRG RPRKQQQEPT CEPSPKRPRG RPKGSKNKSP SKAAQKKAET IGEKRPRGRP RKWPQQVVQK KPAQETEETS SQESAEED
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 668
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. Plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes. Plays a role in postnatal myogenesis, is involved in satellite cell activation. Positively regulates IGF2 expression through PLAG1 and in a PLAG1-independent manner.
基因功能參考文獻：
1. MiR-495 inhibits new bone regeneration via targeting high mobility group AT-Hook 2 (HMGA2). PMID: 28963864
2. Our findings demonstrate that upon program of benign papilloma to malignant cSCC of skin tumorigenesis, Hmga2 translocates in a ROCK-dependent manner from the membrane to the nucleus, where it serves as an autoregulatory transcription factor, causing cell transformation. PMID: 28415789
3. Tumors lacking the ability to induce Hmga2 proceeded to initiate cutaneous spindle cell and squamous cell carcinomas with all the typical pathological and molecular hallmarks of these cancers. PMID: 26901496
4. these findings demonstrate that expression of Hmga2 cooperates with Jak2(V617F) in the pathogenesis of Mmyelofibrosis. PMID: 28637665
5. Developmental regulation of myeloerythroid progenitor function by the Lin28b-let-7-Hmga2 axis. PMID: 27401346
6. HMGA2 promotes the release of pro-inflammatory cytokines through NF-kappaB pathway, and the dysregulation of HMGA2 may involve with hypermethylation PMID: 28502886
7. STAT3 and HMGA2 cooperatively promote adipogenesis which shows that the STAT3 related transcription factor is involved in adipogenesis PMID: 27940362
8. miR221 targets HMGA2 to inhibit leomycininduced pulmonary fibrosis through the TGFbeta1/Smad3 signaling pathway. PMID: 27513632
9. miR-33-5p regulates osteoblast differentiation partially via Hmga2. PMID: 26980276
10. The Hmga2 gene is activated by Otx2 and Hmga2 protein binds to the enhancers targeted by Otx2, thus facilitating the engagement and/or the stable association of Otx2. PMID: 27036552
11. miR-23b acts as a suppressor of epithelial-to-mesenchymal transition in diabetic nephropathy through repressing PI3K-AKT signaling pathway by targeting HMGA2 and thus alleviating the disease. PMID: 26646104
12. Let-7 depletion drives a stem cell phenotype and the development of intestinal cancer, primarily via Hmga2. PMID: 26244988
13. The expansion of thymopoiesis in neonatal mice is dependent on expression of Hmga2. PMID: 25933067
14. These data provide for the first time the tissue-specific expression and transcription level of Hmga2 during inner ear development. PMID: 24551154
15. The role of the high-mobility-group AT-hook protein 2 (HMGA2) during lung development by analyzing the lung of Hmga2-deficient mice (Hmga2(-/-)), was investigated. PMID: 24661562
16. MYCN/LIN28B/Let-7/HMGA2 pathway implicated by meta-analysis of GWAS in suppression of post-natal proliferation thereby potentially contributing to aging PMID: 23639551
17. downregulation of let-7 and miR-200 levels initiates and maintains oncostatin M-induced epithelial-to-mesenchymal transition phenotypes, and HMGA2 acts as a master switch of oncostatin M-induced epithelial-to-mesenchymal transition. PMID: 23318420
18. MicroRNA-33a mediates the regulation of high mobility group AT-hook 2 gene (HMGA2) by thyroid transcription factor 1 (TTF-1/NKX2-1). PMID: 23625920
19. miR-10A and miR-21 regulate endothelial progenitor cell senescence by down-regulating Hmga2 expression. PMID: 23072816
20. data demonstrate that the HMGA2-IGF2BP2 axis functions as a key regulator of satellite cell activation and therefore skeletal muscle development PMID: 23177649
21. An emphasis has been placed on the HMGA2 studies which have defined its critical role in mesenchymal proliferation and differentiation. PMID: 20123068
22. Histone deacetylase inhibition is associated with transcriptional repression of the Hmga2 gene. PMID: 12799440
23. genomic region from -8.1 to -3.7kb upstream from the initiation site has been found to recapitulate most of the spatial and temporal endogenous Hmga2 gene expression PMID: 13679031
24. Functional interaction between HMGA2 and Nek2 plays a crucial role in the correct process of chromatin condensation in meiosis PMID: 14668482
25. HMGA2 differentially regulates expression of IMP family members during embryogenesis. PMID: 15225648
26. results reveal a novel function of HMGA-2 in skeletal muscle differentiation PMID: 16007198
27. The temperature dependence of binding enthalpy for poly(dA-dT)2 indicates a large heat capacity of binding of -705(+/-113) cal/molK, consistent with an important role of solvent displacement in the linked folding/binding processes in this system. PMID: 16109425
28. Endogenous HMGA2 mediates Epithelial-mesenchymal transition (EMT) by TGF-beta, whereas ectopic HMGA2 causes irreversible EMT characterized by severe E-cadherin suppression. PMID: 16831886
29. it is reported that chromosomal translocations previously associated with human tumors disrupt repression of Hmga2 by let-7 miRNA PMID: 17322030
30. Data show that HMGA2, a member of the HMGA sub-family of HMG proteins, has a critical function in cardiogenesis. PMID: 18425117
31. HMGA2 cooperates with the TGF-beta/Smad pathway in regulating SNAIL1 gene expression. PMID: 18832382
32. Recent studies link a chromatin-associated protein, HMGA2, to development, height, and mouse stem cell aging during late fetal development and young adulthood. PMID: 19070572
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亞細胞定位：

Nucleus.
蛋白家族：

HMGA family
組織特異性：

Expressed in mitotic spermatogonia, meiotic spermatocytes, and postmeiotic round spermatids (at protein level). Expressed in embryonic myogenic progenitor cells.
數據庫鏈接：

KEGG: mmu:15364

STRING: 10090.ENSMUSP00000072556

UniGene: Mm.157190