Recombinant Mouse Haptoglobin (Hp)

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中文名稱：

小鼠Hp重組蛋白
品名簡稱：

Recombinant Mouse Haptoglobin protein
貨號：

CSB-EP010691MO
說明書：

MSDS Datasheet
規格：

￥2328
圖片：
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

Greater than 85% as determined by SDS-PAGE.
基因名：

Hp
Uniprot No.：

Q61646
種屬：

Mus musculus (Mouse)
蛋白長度：

Full Length of Mature Protein
來源：

E.coli
分子量：

40.9 kDa
表達區域：

19-347aa
氨基酸序列

VELGNDAMDFEDDSCPKPPEIANGYVEHLVRYRCRQFYRLRAEGDGVYTLNDEKQWVNTVAGEKLPECEAVCGKPKHPVDQVQRIIGGSMDAKGSFPWQAKMISRHGLTTGATLISDQWLLTTAKNLFLNHSETASAKDITPTLTLYVGKNQLVEIEKVVLHPNHSVVDIGLIKLKQRVLVTERVMPICLPSKDYIAPGRVGYVSGWGRNANFRFTDRLKYVMLPVADQDKCVVHYENSTVPEKKNLTSPVGVQPILNEHTFCAGLTKYQEDTCYGDAGSAFAIHDMEEDTWYAAGILSFDKSCAVAEYGVYVRATDLKDWVQETMAKN
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 6xHis-tagged
產品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

3-7 business days
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway.
基因功能參考文獻：
1. Both immunoblot analyses and enzymelinked immunosorbent assays confirmed the increased concentration of haptoglobin in crude mdx4cv serum. This suggests that haptoglobin, in conjunction with other altered serum proteins, represents a novel diagnostic, prognostic and/or therapymonitoring biomarker candidate to evaluate the inflammatory response in the mdx4cv animal model of dystrophinopathy. PMID: 28440464
2. Data show that zonulin-dependent small intestinal barrier impairment is an early step leading to the break of tolerance with subsequent development of chronic inflammatory diseases (CIDs). PMID: 28423466
3. the interaction between haptoglobin genotype and vitamin E affects atherosclerotic plaque progression and stability PMID: 25618031
4. Suggest haptoglobin is an enhancer of inflammation after cardiac transplantation, contributing to graft rejection. PMID: 25801896
5. Zonulin facilitates development of acute lung injury (ALI) both by enhancing albumin leak and complement activation as well as increased buildup of neutrophils and cytokines during development of ALI. PMID: 23564505
6. Haptoglobin deficiency is associated with leakage-prone vessels via isolated VEGFA induction and/or suppressed Ang-1 expression, resulting in unbalanced VEGFalpha/Ang-1 transcription. PMID: 23274064
7. Hp generated by the B-cell compartment, rather than by the liver, is functionally contributing to a normal immune response. PMID: 23548836
8. the Hp2-2 protein is involved in aneurysm formation and that the Hp genotype may be a useful biomarker in predicting aneurysm progression PMID: 23096414
9. Experimental models of colitis showed that haptoglobin has a protective role in inflammatory colitis PMID: 21708824
10. these studies provide direct evidence that the increased oxidative stress in Hp 2-2 atherosclerotic plaques is due to hemoglobin derived iron. PMID: 19775690
11. Synthetic PPAR gamma ligands selectively activate PPAR gamma bound to the haptoglobin gene promoter to arrest haptoglobin gene transcription. PMID: 19952271
12. Hp may be regarded as a regulator of the Th1/Th2 balance in both human and murine immune systems. PMID: 11865978
13. Hp plays a pivotal role in reducing renal oxidative damage during haemolysis. PMID: 11865980
14. Haptoglobin gene expression regulation PMID: 11865981
15. haptoglobin and hemopexin together are essential for protection from splenomegaly and liver fibrosis resulting from intravascular hemolysis PMID: 12393471
16. the haptoglobin gene expression in adipocytes is stimulated by inflammatory cytokines, glucocorticoids, and the sympathetic system PMID: 14697247
17. haptoglobin-mediated heme-iron recovery may contribute significantly to iron loading in hemochromatosis PMID: 15613548
18. a direct linkage between diabetic vascular disease and the Hp genotype. PMID: 15852445
19. Increased prevalence of diabetic retinopathy in individuals with the haptoglobin 2 genotype. PMID: 16742000
20. Increased iron, lipid peroxidation and macrophage accumulation in ApoE-/- Hp 2-2 plaques suggests that the haptoglobin genotype plays a critical role in the oxidative and inflammatory response to intraplaque hemorrhage. PMID: 17068284
21. The reduction in reverse cholesterol transport associated with diabetes mellitus was significantly greater in Hp2-2 mice as compared with Hp1-1 mice PMID: 17082477
22. results suggest that correct processing of haptoglobin may be sensitive to ER stress & that, in absence of GRP78-mediated assistance, Hp is degraded; data show that iron regulates haptoglobin synthesis & suggest possible link with iron-induced ER stress PMID: 17644369
23. Suggest that haptoglobin, by controlling plasma levels of hemoglobin, participates in the regulation of ferroportin expression, thus contributing to the regulation of iron transfer from duodenal mucosa to plasma. PMID: 17919498
24. the Hp 2-2 genotype is critical for the development of severe vasospasm, which typically occurs 24 hours after SAH in mice PMID: 17962599
25. The phenotype of Hp-deficient mice suggests a major regulatory activity for Hp in supporting proliferation and functional differentiation of B and T cells as part of homeostasis and in response to antigen stimulation. PMID: 18436583
26. Pharmacogenomic effect of vitamin E on kidney structure and function in transgenic mice with the haptoglobin 2-2 genotype and diabetes mellitus. PMID: 19176700
27. HDL can become proinflammatory via the hemoglobin x Hp pathway in mice and humans PMID: 19433579
28. In diabetic mice the Hp 2-2 genotype is associated with increased mortality and more severe cardiac remodeling 30 days after myocardial infarct. PMID: 19490627
29. Results suggest that HP plays a modulatory and protective role on autoimmune inflammation of the CNS. PMID: 19795414
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亞細胞定位：

Secreted.
蛋白家族：

Peptidase S1 family
組織特異性：

Expressed by the liver and secreted in plasma.
數據庫鏈接：

KEGG: mmu:15439

STRING: 10090.ENSMUSP00000074436

UniGene: Mm.26730