Recombinant Mouse General transcription factor IIH subunit 3 (Gtf2h3)

中文名稱：

小鼠Gtf2h3重組蛋白
貨號：

CSB-YP837710MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Gtf2h3重組蛋白
貨號：

CSB-EP837710MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Gtf2h3重組蛋白
貨號：

CSB-EP837710MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Gtf2h3重組蛋白
貨號：

CSB-BP837710MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Gtf2h3重組蛋白
貨號：

CSB-MP837710MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Gtf2h3
Uniprot No.：

Q8VD76
別名：

Gtf2h3; General transcription factor IIH subunit 3; Basic transcription factor 2 34 kDa subunit; BTF2 p34; General transcription factor IIH polypeptide 3; TFIIH basal transcription factor complex p34 subunit
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達區域：

1-309
氨基酸序列

MAADEDELNL LVIIVDTNPI WWGKQALKES QFTLSKCMDA VMVLANSHLF MNRSNQLAVI ASHIQESRLL YPGKNGGLGD FFGDPGNALP DCNPSGSKDG KYELLTVANE VIAEEIKDLM TKSDIKGQHT ETLLAGSLAK ALCYIHRVNK AVKDNQEMKS RILVIKAAED SALQYMNFMN VIFAAQKQNI LIDACVLDSD SGLLQQACDI TGGLYLKVPQ MPSLLQYLLW VFLPDQDQRS QLILPPPIHV DYRAACFCHR SLIEIGYVCS VCLSIFCNFS PICTTCETAF KISLPPVLKA KKKKQKVSL
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.
基因功能參考文獻：
1. Mutations in TFIIH causing trichothiodystrophy are responsible for defects in ribosomal RNA production and processing. PMID: 23562818
2. Data show that that B2 RNA, when present with Pol II in promoter-bound complexes, specifically represses CTD phosphorylation by TFIIH. PMID: 21326911
3. Molecular analyses performed on the mice brain tissue demonstrate that TFIIH is required for the stabilization of thyroid hormone receptors (TR) to their DNA-responsive elements. PMID: 17952069
亞細胞定位：

Nucleus.
蛋白家族：

TFB4 family
數據庫鏈接：

KEGG: mmu:209357

STRING: 10090.ENSMUSP00000031333

UniGene: Mm.185467