Recombinant Mouse Gastrin-releasing peptide (Grp)

中文名稱：

小鼠Grp重組蛋白
貨號：

CSB-YP009940MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Grp重組蛋白
貨號：

CSB-EP009940MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Grp重組蛋白
貨號：

CSB-EP009940MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Grp重組蛋白
貨號：

CSB-BP009940MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Grp重組蛋白
貨號：

CSB-MP009940MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Grp
Uniprot No.：

Q8R1I2
別名：

Grp; Gastrin-releasing peptide; GRP) [Cleaved into: Neuromedin-C; GRP-10)]
種屬：

Mus musculus (Mouse)
蛋白長度：

Cytoplasmic domain
表達區域：

24-52
氨基酸序列

APVSTGA GGGTVLAKMY PRGSHWAVGH LM
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Stimulates the release of gastrin and other gastrointestinal hormones. Contributes to the perception of prurient stimuli and to the transmission of itch signals in the spinal cord that promote scratching behavior. Contributes primarily to nonhistaminergic itch sensation. Contributes to long-term fear memory, but not normal spatial memory. Contributes to the regulation of food intake.
基因功能參考文獻：
1. These data suggest that GRPR expression in fibroblast-like synoviocytes (FLS)and that exogenous GRP are able to activate FLS invasion. This effect occurs at least in part through the AKT activation. Therefore, understanding of the GRP/GRPR pathway could be relevant in the development of FLS-targeted therapy for Rheumatoid arthritis . PMID: 28733141
2. Fos and phosphorylation of extracellular signal-regulated kinases (ERK) were used to look for evidence that interneurons expressing GRP were activated following intradermal injection of chloroquine. PMID: 27270268
3. GrpmRNA and protein are upregulated in dorsal root ganglias, but not in the spinal cord, of mice with chronic itch. PMID: 27068287
4. GRP is expressed by a distinct population of excitatory interneurons in laminae I-II that are likely to be involved in the itch pathway PMID: 25496164
5. BNP-NPRA signaling is involved in both itch and pain and does not function upstream of the GRP-GRPR dedicated neuronal pathway. PMID: 24438367
6. nonamidated peptides derived from the C terminus of pro-GRP are expressed in significant quantities in colorectal cancer cell lines PMID: 22202166
7. GRP delays the phase of the clock during the early night by prolonging day-like membrane properties of SCN cells PMID: 21454290
8. The GRP receptor system does not mediate kappa opioid receptor antagonist (GNTI)-induced scratching. The kappa opioid system is involved, at least in part, in the scratch suppressing activity of the kappa opioid receptor agonist nalfurafine. PMID: 21126550
9. These studies demonstrate that (64)Cu-SarAr-SA-Aoc-bombesin(7-14) and (64)Cu-SarAr-SA-Aoc-GSG-bombesin(7-14) bound with high affinity to GRPR-expressing cells. PMID: 21321264
10. A general possible effect of GRP on cortical inhibitory transmission, was shown. PMID: 20836873
11. GRP/GRP-R play a transient and non-critical role in intestinal development PMID: 11960700
12. GRP has a role in regulation of fear and memory for fear in the mouse amygdala PMID: 12526815
13. Potential new role for gastrin-releasing peptide -BB2 signaling within the circadian clock. PMID: 16319315
14. New evidence for the occurrence of marked effects of bombesin/gastrin-releasing peptide concerning both the articular chondrocytes and the inflammatory process is obtained in this study PMID: 17911468
15. GRP nerve fibers were markedly high in the epidermis of atopic dermatitis mice PMID: 19571818
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亞細胞定位：

Secreted. Cytoplasmic vesicle, secretory vesicle lumen.
蛋白家族：

Bombesin/neuromedin-B/ranatensin family
組織特異性：

Detected in the suprachiasmatic nucleus in the hypothalamus. Detected in peptidergic dorsal root ganglion neurons (at protein level). Highly expressed both in the lateral nucleus of the amygdala, and in regions sending synaptic projections to the lateral
數據庫鏈接：

KEGG: mmu:225642

STRING: 10090.ENSMUSP00000025395

UniGene: Mm.20298