Recombinant Mouse Gap junction alpha-3 protein (Gja3), partial

中文名稱：

小鼠Gja3重組蛋白
貨號：

CSB-YP737359MO1
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Gja3重組蛋白
貨號：

CSB-EP737359MO1
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Gja3重組蛋白
貨號：

CSB-EP737359MO1-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Gja3重組蛋白
貨號：

CSB-BP737359MO1
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Gja3重組蛋白
貨號：

CSB-MP737359MO1
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Gja3
Uniprot No.：

Q64448
別名：

Gja3; Gap junction alpha-3 protein; Connexin-46; Cx46
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Structural component of lens fiber gap junctions. Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane. Small molecules and ions diffuse from one cell to a neighboring cell via the central pore.
基因功能參考文獻：
1. that expression and phosphorylation of connexin 46 and connexin 45 are complementary in seminiferous tubules PMID: 26017495
2. The localization and sizes of Cx50 gap junction plaques in DKO fibers were unaffected, suggesting that Cx46 and Cx50 form homomeric channels PMID: 25740157
3. Data indicate that connexin 46 (cx46) is essential for the maintenance of adequate levels of glutathione (GSH) in the lens nucleus. PMID: 25294879
4. Cx46 was severely reduced in both heterozygous and homozygous Cx46fs380 lenses at 1 month of age, whereas immunoreactive connexin50 (Cx50) was moderately decreased. PMID: 25103261
5. Results suggest that Cx46 hemichannels may contribute to the sodium leak conductance in lens fiber cells. PMID: 24380846
6. There were no observed changes in gene expression as a result of the lack of alpha3Cx46 in the different mouse strains. PMID: 20104256
7. nonspecific restoration of communication by Cx46 maintained differentiation of lens cells PMID: 11786642
8. Transient decrease in gap junction expression during compensatory renal growth in mice PMID: 12385951
9. Results indicates connexin 46 expressed alone are recruited into different lipid environments and interaction of connexins and MP26 contributes to the overall organization of the fiber cells. PMID: 16740340
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亞細胞定位：

Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
蛋白家族：

Connexin family, Alpha-type (group II) subfamily
數據庫鏈接：

KEGG: mmu:14611

STRING: 10090.ENSMUSP00000059587

UniGene: Mm.57207