Recombinant Mouse Fos-related antigen 2 (Fosl2)

中文名稱：

小鼠Fosl2重組蛋白
貨號：

CSB-YP008793MO
規(guī)格：
來源：

Yeast
其他：

中文名稱：

小鼠Fosl2重組蛋白
貨號：

CSB-EP008793MO
規(guī)格：
來源：

E.coli
其他：

中文名稱：

小鼠Fosl2重組蛋白
貨號：

CSB-EP008793MO-B
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Fosl2重組蛋白
貨號：

CSB-BP008793MO
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Fosl2重組蛋白
貨號：

CSB-MP008793MO
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
靶點詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Fosl2
Uniprot No.：

P47930
別名：

Fosl2; Fra-2; Fra2Fos-related antigen 2; FRA-2
種屬：

Mus musculus (Mouse)
蛋白長度：

Full length protein
表達(dá)區(qū)域：

1-326
氨基酸序列

MYQDYPGNFD TSSRGSSGSP AHAESYSSGG GGQQKFRVDM PGSGSAFIPT INAITTSQDL QWMVQPTVIT SMSNPYPRSH PYSPLPGLAS VPGHMALPRP GVIKTIGTTV GRRRRDEQLS PEEEEKRRIR RERNKLAAAK CRNRRRELTE KLQAETEELE EEKSGLQKEI AELQKEKEKL EFMLVAHGPV CKISPEERRS PPTSGLQSLR GTGSAVGPVV VKQEPPEEDS PSSSAGMDKT QRSVIKPISI AGGGFYGEEP LHTPIVVTST PAITPGTSNL VFTYPNVLEQ ESPSSPSESC SKAHRRSSSS GDQSSDSLNS PTLLAL
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Controls osteoclast survival and size. As a dimer with JUN, activates LIF transcription. Activates CEBPB transcription in PGE2-activated osteoblasts.
基因功能參考文獻(xiàn)：
1. Fra-2 overexpression might impair myofibroblast functions crucial for secondary septation PMID: 28818870
2. Data show that Fos-Related Antigen-2 (Fra-2) is a key upstream regulator of forkhead box O1 (Foxo1) and interferon regulatory factor 4 (Irf4) expression and influences proliferation and differentiation of B cells at multiple stages. PMID: 28566276
3. Deletion of Fra-2 leads to increased PPARgamma2 expression and adipocyte differentiation as well as increased adipocyte apoptosis through upregulation of hypoxia-inducible factors. PMID: 24464219
4. Cytokine-mediated Fra-2 expression and stabilization is linked to regulation of myogenic progenitor cells. PMID: 23807221
5. AP-1 composed with JunD and Fra2 protein plays a primary role in enhancing the transcription level of the CD11c gene in dendritic cells PMID: 22990073
6. FOSL2 is a critical regulator of leptin expression in adipocytes PMID: 22326952
7. Identify Fra-2 as an O(2)-sensitive transcriptional regulator of inducible TGFbeta expression and position Fra-2 as an important player in reoxygenation-induced myocardial fibrosis. PMID: 20427335
8. Since transgenic overexpression of Fra-2 causes not only fibrosis but also vascular disease, Fra-2 might be an interesting novel candidate for molecular-targeted therapies for systemic sclerosis. PMID: 20039427
9. Fra2 is a novel transcription factor important for skeletogenesis by affecting chondrocyte differentiation PMID: 15509771
10. MEKK1 regulates Fra-2 protein stability by inducing Fra-2 ubiquitination and degradation. PMID: 15558021
11. NFATc1 negatively regulates osteoblst differentiation by regulating fra-2 PMID: 16340132
12. These data identify junD proto-oncogene (JunD) and Fos-related antigen 2 (Fra-2) as the activator protein-1 (AP-1) factors responsible for the RANKL-induced upregulation of the mouse Tcirg1 gene expression. PMID: 17419679
13. Fos-related protein Fra-2 controls osteoclast survival and size PMID: 18548006
14. Fra-2 is necessary for regulation of normal invariant natural killer (iNK)T cell development and function; loss of Fra-2 causes a 2.5-fold increase in thymic iNKT cells. PMID: 19620306
15. Fra-2 transcripion factor induces progressive peripheral vasculopathy in mice that resembles human systemic sclerosis. PMID: 19933934
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亞細(xì)胞定位：

Nucleus.
蛋白家族：

BZIP family, Fos subfamily
數(shù)據(jù)庫鏈接：

KEGG: mmu:14284

STRING: 10090.ENSMUSP00000031017

UniGene: Mm.24684