Recombinant Mouse Forkhead box protein P1 (Foxp1)

中文名稱：

小鼠Foxp1重組蛋白
貨號：

CSB-YP008841MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Foxp1重組蛋白
貨號：

CSB-EP008841MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Foxp1重組蛋白
貨號：

CSB-EP008841MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Foxp1重組蛋白
貨號：

CSB-BP008841MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Foxp1重組蛋白
貨號：

CSB-MP008841MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Foxp1
Uniprot No.：

P58462
別名：

Foxp1Forkhead box protein P1; Forkhead-related transcription factor 1
種屬：

Mus musculus (Mouse)
蛋白長度：

Full length protein
表達區域：

1-705
氨基酸序列

MMQESGSETK SNGSAIQNGS SGGNHLLECG ALRDTRSNGE APAVDLGAAD LAHVQQQQQQ ALQVARQLLL QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQQVSG LKSPKRNDKQ PALQVPVSVA MMTPQVITPQ QMQQILQQQV LSPQQLQVLL QQQQALMLQQ QLQEFYKKQQ EQLQLQLLQQ QHAGKQPKEQ QVATQQLAFQ QQLLQMQQLQ QQHLLSLQRQ GLLTIQPGQP ALPLQPLAQG MIPTELQQLW KEVTSAHTAE ETTSSNHSSL DLTSTCVSSS APSKSSLIMN PHASTNGQLS VHTPKRESLS HEEHPHSHPL YGHGVCKWPG CEAVCDDFPA FLKHLNSEHA LDDRSTAQCR VQMQVVQQLE LQLAKDKERL QAMMTHLHVK STEPKAAPQP LNLVSSVTLS KSASEASPQS LPHTPTTPTA PLTPVTQGPS VITTTSMHTV GPIRRRYSDK YNVPISSADI AQNQEFYKNA EVRPPFTYAS LIRQAILESP EKQLTLNEIY NWFTRMFAYF RRNAATWKNA VRHNLSLHKC FVRVENVKGA VWTVDEVEFQ KRRPQKISGN PSLIKNMQSS HAYCTPLNAA LQASMAENSI PLYTTASMGN PTLGSLASAI REELNGAMEH TNSNESDSSP GRSPMQAVHP IHVKEEPLDP EEAEGPLSLV TTANHSPDFD HDRDYEDEPV NEDME
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Transcriptional repressor. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays an important role in the specification and differentiation of lung epithelium. Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program; the function may involve regulation of AGR2. Essential transcriptional regulator of B-cell development. Involved in regulation of cardiac muscle cell proliferation. Involved in the columnar organization of spinal motor neurons. Promotes the formation of the lateral motor neuron column (LMC) and the preganglionic motor column (PGC) and is required for respective appropriate motor axon projections. The segment-appropriate generation of spinal chord motor columns requires cooperation with other Hox proteins. Can regulate PITX3 promoter activity; may promote midbrain identity in embryonic stem cell-derived dopamine neurons by regulating PITX3. Negatively regulates the differentiation of T follicular helper cells T(FH)s. Involved in maintenance of hair follicle stem cell quiescence; the function probably involves regulation of FGF18. Represses transcription of various pro-apoptotic genes and cooperates with NF-kappa B-signaling in promoting B-cell expansion by inhibition of caspase-dependent apoptosis. Binds to CSF1R promoter elements and is involved in regulation of monocyte differentiation and macrophage functions; repression of CSF1R in monocytes seems to involve NCOR2 as corepressor. Involved in endothelial cell proliferation, tube formation and migration indicative for a role in angiogenesis; the role in neovascularization seems to implicate suppression of SEMA5B. Can negatively regulate androgen receptor signaling. Acts as a transcriptional activator of the FBXL7 promoter; this activity is regulated by AURKA.; Involved in transcriptional regulation in embryonic stem cells (ESCs). Stimulates expression of transcription factors that are required for pluripotency and decreases expression of differentiation-associated genes. Has distinct DNA-binding specifities as compared to the canonical form and preferentially binds DNA with the sequence 5'-CGATACAA-3' (or closely related sequences). Promotes ESC self-renewal and pluripotency.
基因功能參考文獻：
1. we have shown that the Foxp1 pathway is involved in regulating the migration kinetics of activated CD4+ T cells toward B cell follicles, indicating that Foxp1 is involved in Tfh cell differentiation from the beginning of a CD4+ T cell response. PMID: 29212910
2. These results identify Foxp1 as a physiological regulator of mature B cell survival mediated in part via the control of Bcl-xl expression and imply that this pathway might contribute to the pathogenic function of aberrant Foxp1 expression in lymphoma. PMID: 29507226
3. FOXP1-knockdown in utero reduces NSC differentiation and migration during corticogenesis. FOXP1 represses expression of Notch pathway genes. PMID: 29141232
4. Foxp1 has a putative HuR binding sites in the 3' UTR. HuR suppresses Foxp1 translation during early neocortical neurogenesis (E13). In HuR knockout mice, decreased Foxp1 mRNA was paralleled by increased Foxp1 protein at E13. Phosphorylation sites on HuR act in post-transcriptional regulation of Foxp1. PMID: 27383233
5. Study identified the roles of Foxo1 as a positive regulator and Foxp1 as a negative regulator of TH9 cell differentiation and antitumor activity. PMID: 29018172
6. deletion of Foxp1 in the developing forebrain leads to impairments in neonatal vocalizations as well as neocortical cytoarchitectonic alterations via neuronal positioning and migration PMID: 29138280
7. Foxp1 conditional knock-out (Foxp1(cKO)) mice with loss of Foxp1 in the neocortex and hippocampus display autism and intellectual-disability-relevant behaviors PMID: 28978667
8. These results indicate that FOXP1 attenuates MSC senescence by orchestrating their cell-fate switch while maintaining their replicative capacity in a dose- and age-dependent manner. PMID: 28240601
9. Although the mutant huntingtin gene is expressed widely, neurons of the striatum and cortex are selectively affected in Huntington's disease (HD). Our results suggest that this selectivity is attributable to the reduced expression of Foxp1, a protein expressed selectively in striatal and cortical neurons that plays a neuroprotective role in these cells. PMID: 28550168
10. studies suggest that Foxp1 enforces naive CD8(+) T cell quiescence by simultaneously repressing key pathways in both cellular metabolism and cell cycle progression PMID: 27001958
11. Loss of Foxp1 results in loss of suture and fiber cell alignment, which eventually causes lens opacity, suggesting that Foxp1 has a key role in establishing cortical lens architecture. PMID: 28384713
12. we demonstrated for the first time that Foxp1 and Foxp2 are expressed during craniofacial development. Our data suggest that the Foxp genes may regulate development of the aboral and posterior regions of the jaw. PMID: 26969076
13. Combined loss of all three Foxp1/2/4 family members in the developing anterior foregut endoderm leads to a loss of lung endoderm lineage commitment and subsequent development. Foxp1/2/4 deficient lungs express high levels of transcriptional regulators not normally expressed in developing lung. Foxp1 binds to conserved forkhead DNA binding sites within the Hoxa9-13 cluster, indicating a direct repression mechanism. PMID: 27341756
14. We show that Foxp1 and the androgen receptor are co-expressed in striatal medium spiny neurons and that brain-specific androgen receptor KO (ArNesCre) mice exhibit reduced Foxp1 expression in the striatum at E17.5 and P7.5 and an increased Foxp2 level in the cortex at P7.5. Thus, androgens may contribute to sex-specific differences in Foxp1 and Foxp2 expression and ultrasonic vocalizations PMID: 28204507
15. This study demonstrated the utility of FoxP1 to label MSNs in vitro and following neural transplantation, and show that FoxP1 is required for DARPP-32 positive MSN differentiation in vitro. PMID: 27154297
16. En1-null cells also fail to express the transcription factor FoxP1, suggesting that FoxP1 lies downstream of En1. PMID: 26542008
17. The response of CPLX1 and Foxp1 levels to SNCA deficiency supports the notion that these factors are regulated by altered physiological function of alpha-synuclein. PMID: 25112678
18. These results identify a previously unrecognized role for FOXP1 in the transcriptional control of hepatic glucose homeostasis. PMID: 26504089
19. results demonstrate critical roles of Foxp1 in the radial migration and morphogenesis of cortical neurons during development. PMID: 26010426
20. a novel role for Foxp1 in controlling HFSC proliferation with cellular dynamic location in response to oxidative stress during hair cycling PMID: 26171970
21. Foxp1 mediates programming of limb-innervating motor neurons from mouse and human embryonic stem cells. PMID: 25868900
22. The results unveil a fundamental mechanism of T cell unresponsiveness different from anergy or exhaustion, driven by TGF-beta signaling on tumor-associated lymphocytes undergoing Foxp1-dependent transcriptional regulation. PMID: 25238097
23. Foxp1 also dampened expression of the costimulatory molecule ICOS and its downstream signaling at early stages of T cell activation PMID: 24859450
24. data indicate that FoxP1 is essential for the angiogenic function of endothelial cells and functions as a suppressor of the inhibitory guidance cue semaphorin 5B, suggesting A function of FoxP1 in the regulation of neovascularization. PMID: 24023716
25. FOXP1 represents an important modulator of FOXO-induced transcription, promoting cellular survival. PMID: 23832113
26. Foxp1 regulates the quiescent stem cell state in the hair follicle stem cell niche by controlling Fgf18 expression. PMID: 23946441
27. Foxp1 is a transcriptional repressor of immune signaling in the central nervous system. PMID: 22492998
28. Study shows that tembryonic stem cell (ESC)-specific isoform of FOXP1 stimulates expression of transcription factor genes required for pluripotency, OCT4, NANOG, NR5A2, and GDF3, while concomitantly repressing genes required for ESC differentiation. PMID: 21924763
29. Results demonstrate that Foxp1 exerts essential cell-intrinsic regulation of naive T cell quiescence, providing direct evidence that lymphocyte quiescence is achieved through actively maintained mechanisms that include transcriptional regulation. PMID: 21532575
30. The response of LMC motor neurons to Reelin is gated by Foxp1- and Lhx1-mediated regulation of expression of the critical Reelin signalling intermediate Dab1. PMID: 20711475
31. Foxp1 coordinates the balance of cardiomyocyte proliferation and differentiation through cell lineage-specific regulation of Fgf ligand and Nkx2.5 expression PMID: 20713518
32. Thus, this study demonstrates for the first time a transcription regulatory role for FoxP1 on the Pitx3 gene in mammalian stem cells. PMID: 20175877
33. alpha-Synuclein-deficient mice display a prominent downregulation of Foxp1 transcript sustained since postnatal age and throughout the brain. PMID: 20056137
34. Foxp1 is an essential transcriptional regulator for thymocyte development and the generation of quiescent naive T cells. PMID: 19965654
35. Foxp1 mRNA is most highly expressed in developing and mature basal ganglia and is also observed in the cerebral cortex (layers 3-5), hippocampus (CA1), and thalamus. PMID: 12687690
36. Foxp1 was highly expressed in the striatum and moderately in other ares of brain, in a subset of projection neurons, not in interneurons and in the developing basal ganglia with the exception of the globus pallidus PMID: 14980377
37. a crucial role for Foxp1 in three aspects of cardiac development: (1) outflow tract development and septation, (2) tissue remodeling events required for cardiac cushion development, and (3) myocardial maturation and proliferation PMID: 15342473
38. Foxp2 and Foxp1 are crucial regulators of lung and esophageal development PMID: 17428829
39. Findings show that FoxP1 is a crucial determinant of motor neuron diversification and connectivity, and clarify how this Hox regulatory network controls the formation of a topographic neural map. PMID: 18662545
40. Forkhead domain transcription factor Foxp1 plays a critical role in defining the columnar identity of motor neurons at each axial position. PMID: 18667151
41. Foxp1 is critical for monocyte differentiation and macrophage functions in vivo. PMID: 18799727
42. FoxP conducting the Hox symphony in spinal motor neurons. PMID: 18818591
43. Foxp1 and Foxp2 may be involved in the determination of the cell type identities during late embryogenesis. PMID: 19463901
44. Foxp1 may play some important roles in the determination of neuronal fates of the ventral spinal cord, possibly through the suppression of Lhx3 expression. PMID: 19797899
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亞細胞定位：

Nucleus.
組織特異性：

Isoform 5 is specifically expressed in embryonic stem cells. Highest expression in the lung, brain, and spleen. Lower expression in heart, skeletal muscle, kidney, small intestine (isoform 3 not present) and liver.
數據庫鏈接：

KEGG: mmu:108655

STRING: 10090.ENSMUSP00000073953

UniGene: Mm.234965