Recombinant Mouse Endothelin-2 (Edn2)

中文名稱：

小鼠Edn2重組蛋白
貨號：

CSB-YP007401MO
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Edn2重組蛋白
貨號：

CSB-EP007401MO-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Edn2重組蛋白
貨號：

CSB-BP007401MO
規格：
來源：

Baculovirus
其他：

產品詳情
產品評價
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靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Edn2
Uniprot No.：

P22389
別名：

Edn2Endothelin-2; ET-2; Preproendothelin-2; PPET2; Vasoactive intestinal contractor; VIC
種屬：

Mus musculus (Mouse)
蛋白長度：

Cytoplasmic domain
表達區域：

46-66
氨基酸序列

CSCNS WLDKECVYFC HLDIIW
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Vasoconstrictor.
基因功能參考文獻：
1. Follicle rupture and fertility were significantly impaired in the absence of ovarian Edn2 expression. PMID: 28400616
2. The results demonstrated that long-term hyperglycaemia in conjunction with VEGF-driven retinal neovascularization increased Edn2 serum concentration suggesting Edn2 might be a candidate biomarker for vascular changes in diabetic retinopathy. PMID: 27482904
3. EDN2 is necessary for normal ovulation and corpus luteum formation. PMID: 24763822
4. Endothelin-2 signaling in the neural retina promotes the endothelial tip cell state and inhibits angiogenesis. PMID: 24043815
5. Edn2-mediated mechanisms that contribute to PR survival PMID: 23469133
6. ET-2 is critical for the growth and survival of postnatal mice and plays important roles in energy homeostasis, thermoregulation, and the maintenance of lung morphology and function. PMID: 23676500
7. Since endothelin 2 is potently vasoconstrictive and was produced by microglia/macrophages, our data provide what we believe to be a novel link between these cell types and vascular dysfunction in glaucoma. PMID: 21383504
8. These data indicate that ET-2 is a direct target gene of Hedgehog signaling in basal cell carcinoma. PMID: 19914214
9. sequence analysis and expression; expression level in adults was approx. 10-fold higher than in the foetus, suggesting involvement in intestinal development PMID: 12193061
10. ET-2 gene expression gradually increases after parturition PMID: 12372435
11. Regional differences in central nervous sytem and pituitary gland gene expression noted; Cold injury to the mouse cerebral cortex caused decreased expression PMID: 12507500
12. expression profile & localization in the intestinal tract; results suggest that in intestinal epithelial cells ET-2 could be secreted into the lamina propria & dome region in Peyer's patch & that it might modulate immune cells for mucosal defense PMID: 16216902
13. EDN2 induces follicular rupture by constricting periovulatory follicles. PMID: 16410304
14. These results indicate new three findings, (1) ET-2/VIC expression increases and has potential as a differentiation marker. PMID: 17418814
15. effect of hypoxia on endothelin-2 mRNA expression in granulosa cells at ovulation PMID: 18516093
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亞細胞定位：

Secreted.
蛋白家族：

Endothelin/sarafotoxin family
數據庫鏈接：

KEGG: mmu:13615

STRING: 10090.ENSMUSP00000030384

UniGene: Mm.284855