Recombinant Mouse Elongator complex protein 2 (Elp2), partial

中文名稱：

小鼠Elp2重組蛋白
貨號：

CSB-YP849660MO
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Elp2重組蛋白
貨號：

CSB-EP849660MO
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Elp2重組蛋白
貨號：

CSB-EP849660MO-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Elp2重組蛋白
貨號：

CSB-BP849660MO
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Elp2重組蛋白
貨號：

CSB-MP849660MO
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Elp2
Uniprot No.：

Q91WG4
別名：

Elp2; Statip1Elongator complex protein 2; ELP2; STAT3-interacting protein 1; StIP1
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation. The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.
基因功能參考文獻：
1. Elp2 role in the development of the ureter obstruction induced renal fibrosis.Elp2 regulates Stat3 and TGF-beta1 and NF-kappa B pathways in the renal fibrosis. PMID: 29723529
2. Targeting ELP2 activity as a novel therapeutic option to limit the inhibition of osteoblast differentiation by inflammatory microenvironment. PMID: 25486498
3. US28 induces proliferation in HCMV-infected tumors by establishing a positive feedback loop through activation of the IL-6-STAT3 signaling axis. PMID: 20682912
4. STAT3 interacts with STRA13 and modulates transcription of STAT3-dependent targets. PMID: 15223310
5. Data show that HMGA1a binding activity in nuclear fractions from murine retina, but not from hippocampus, resulted in STAT3 interacting protein 1 (StIP1) that formed a novel complex with HMGA1a, STAT3 and homeodomain-interacting protein kinase 2 (HIPK2). PMID: 16870469
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亞細胞定位：

Cytoplasm. Nucleus.
蛋白家族：

WD repeat ELP2 family
數據庫鏈接：

KEGG: mmu:58523

STRING: 10090.ENSMUSP00000025120

UniGene: Mm.25298