Recombinant Mouse Dynamin-1 (Dnm1), partial

中文名稱：

小鼠Dnm1重組蛋白
貨號：

CSB-YP007062MO
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Dnm1重組蛋白
貨號：

CSB-EP007062MO
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Dnm1重組蛋白
貨號：

CSB-EP007062MO-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Dnm1重組蛋白
貨號：

CSB-BP007062MO
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Dnm1重組蛋白
貨號：

CSB-MP007062MO
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Dnm1
Uniprot No.：

P39053
別名：

Dnm1; Dnm; Kiaa4093Dynamin-1; EC 3.6.5.5
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis.
基因功能參考文獻：
1. dynamin is a molecular motor which would be involved in GLUT4 translocation by facilitating exocytosis PMID: 28853753
2. reveal functional differences between Dnm1a and Dnm1b isoforms in the presence of a challenge, i.e. toxic Dnm1(Ftfl), while reinforcing its effect explicitly in this model of severe pediatric epilepsy PMID: 27363778
3. in the mature epididymis, predominantly localized in clear cells of the distal segments PMID: 28395327
4. Dynamin may facilitate Fas-mediated apoptotic death in the brain, and Hsp70 may protect by preventing this trafficking. PMID: 27387989
5. These results suggested that dynamin 1 was susceptible to the aging process, and that a reduction in dynamin 1 may result in hippocampaldependent memory deficits by disrupting endocytosis and the release of neurotransmitters. PMID: 27748822
6. Tissue-specific dynamin-1 deletion at the calyx of Held decreases short-term depression through a mechanism distinct from vesicle resupply. PMID: 27185948
7. findings support a role for HTT on dynamin 1 function and ER homoeostasis. Proteolysis-induced alteration of this function may be relevant to disease. PMID: 26165689
8. the identification of the oligomerization cycle of dynamin is an attractive potential therapeutic target to treat chronic kidney diseases . PMID: 25962121
9. In the developing neurons, there is a dynamin 1-, dynamin 3- and clathrin-independent pathway of synaptic vesicle recycling mediated by bulk endocytosis. PMID: 24963135
10. Using an inducible knockout mouse model to generate dynamin 1- and 2-deficient primary osteoclast precursors and myoblasts, it was shown that fusion of both cell types requires dynamin. PMID: 25287300
11. Dynamin 1 is required for memory formation. PMID: 24643165
12. As low-level expression of the dynamin 3 gene in these cells could not be excluded, we have now engineered dynamin 1, 2 and 3 triple KO (TKO) fibroblasts. PMID: 24046449
13. Results further implicate dynamin-1 in vesicular protein transport processes relevant to synaptic and post-Golgi pathways and indicate a possible role in photoreceptor stability PMID: 23746204
14. Data indicate that coxsackievirus and adenovirus receptor (CAR) internalization was lipid microdomain-, actin-, and dynamin-dependent, and subsequently followed by CAR degradation in lysosomes. PMID: 24273169
15. A missense mutation of dynamin 1 inhibits endocytosis via clathrin-mediated endocytosis. PMID: 24431429
16. Data indicate that dynamin, clathrin, adaptor protein complex-2 (AP2), and amphiphysin contribute to the depolarization-evoked entry in endocytosis. PMID: 23640057
17. Data show that dynamin 1 and dynamin 2 GTPases localize to the developing acrosome of maturing germ cells. PMID: 22977254
18. S857 phosphorylation of dynamin 1 is modulated by neuronal activity in nerve terminals. PMID: 22857010
19. Analysis of cysteine string protein alpha (CSPalpha)-dynamin 1 interactions reveals unexpectedly that CSPalpha regulates the polymerization of dynamin 1 in mouse hippocampal cell cultures. PMID: 22500636
20. These findings reveal a mechanism aimed at preventing synaptic transmission failure due to vesicle depletion when recycling vesicle traffic is backed up by a defect in dynamin-dependent endocytosis. PMID: 22308498
21. Calcineurin associates with dynamin1 via a PxIxIT interaction motif found only in specific dynamin1 splice variants PMID: 21689596
22. Dynamin 1 and 3, which account for the overwhelming majority of brain dynamin, cooperate in supporting optimal rates of synaptic vesicle endocytosis. PMID: 21689597
23. Calcium-mediated dephosphorylation of dynamin I at Ser-774 leads to the recruitment of the molecular motor myosin II to actively dilate the fusion pore to facilitate release of peptide transmitters. PMID: 21061163
24. It plays a role in synaptic vesicle endocytosis. (review) PMID: 21038613
25. Missense mutation in conserved alternate exon of dynamin-1 causes epilepsy in a mouse model. PMID: 20700442
26. Data identified a number of novel synaptic protein interactions involving soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs), calcium-activated potassium channel (BKCa) alpha subunits, and dynamin-1. PMID: 20114047
27. dynamin forms a complex with caveolin-1. EGF-induced tyrosine phosphorylation of dynamin occurs via a Src inhibitor-sensitive signaling pathway PMID: 11956154
28. dynamin may provide the trigger and actin may provide the force for movement into the cytosol PMID: 12198492
29. Our results show that focal adhesion disassembly involves microtubules, dynamin and FAK, and is not simply the reversal of focal adhesion formation. PMID: 15895076
30. Results suggest that dynamin 2 may be the constitutive counterpart of dynamin 1 in growing neurons. PMID: 16028072
31. Phosphatidylinositol 4,5-bisphosphate releases Pfn2 from the Pfn2-dynamin 1 complex as well as from the Pfn2-actin complex, suggesting that Pfn2 is diverging the phosphoinositide signaling pathway to actin polymerization as well as endocytosis PMID: 16319076
32. dynamin 1-independent mechanisms can support limited synaptic vesicle endocytosis, but dynamin 1 is needed during high levels of neuronal activity PMID: 17463283
33. Dynamin has a role in insulin granule exocytosis PMID: 17848579
34. predominant endocytic structures observed at the majority of dynamin 1 KO synapses after acute stimulation are endosome-like intermediates that originate by a dynamin 1-independent form of endocytosis PMID: 18250322
35. IOP elevation may directly damage mitochondria in the ONH axons by promoting reduction of COX, mitochondrial fission and cristae depletion, alterations of OPA1 and Dnm1 expression, and induction of OPA1 release. PMID: 18469184
36. Data suggest that dynamin I is involved in both modes of exocytosis by regulating contraction or dilation of the fusion pore and thus contributes to activity-dependent differential transmitter release from the adrenal medulla. PMID: 18492483
37. High level expression of dynamin 1 is essential to allow the slow, clathrin-mediated endocytosis, which accounts for the bulk of the endocytic response, to operate efficiently over a wide range of activity. PMID: 18987309
38. Phosphorylated LAB recruits a complex of Grb2-dynamin and the guanine nucleotide exchange factor Vav. Vav is required for activation of the small GTPases Rac1 and Rac2. PMID: 19858206
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亞細胞定位：

Cytoplasm. Cytoplasm, cytoskeleton. Note=Microtubule-associated.
蛋白家族：

TRAFAC class dynamin-like GTPase superfamily, Dynamin/Fzo/YdjA family
數據庫鏈接：

KEGG: mmu:13429

STRING: 10090.ENSMUSP00000088618

UniGene: Mm.44736