Recombinant Mouse Dual specificity protein phosphatase 10 (Dusp10)

中文名稱：

小鼠Dusp10重組蛋白
貨號：

CSB-YP866848MO
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Dusp10重組蛋白
貨號：

CSB-EP866848MO
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Dusp10重組蛋白
貨號：

CSB-EP866848MO-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Dusp10重組蛋白
貨號：

CSB-BP866848MO
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Dusp10重組蛋白
貨號：

CSB-MP866848MO
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Dusp10
Uniprot No.：

Q9ESS0
別名：

Dusp10; Mkp5Dual specificity protein phosphatase 10; EC 3.1.3.16; EC 3.1.3.48; Mitogen-activated protein kinase phosphatase 5; MAP kinase phosphatase 5; MKP-5
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達區域：

1-483
氨基酸序列

MPPSPLDDRV VVALSRPVRP QDLNLCLDSS YLGSASPGSG SHAPVLATAV VTLKAANLTY MPSSSGSARS LNCGCSSTSC CTVATYDKDH QAQTQAIAAG TATTAIGTST TCPANQMVNN NENTGSVLSP SGGVGSPVSG TPKQLASIKI IYPNDLAKKM TKCSKSHLPS QGPVIIDCRP FMEYNKSHIQ GAVHINCADK ISRRRLQQGK ITVLDLISCR EGKDSFKRIF SKEIIVYDEN TNEPSRVTPS QPLHIVLESL KREGKEPLVL KGGLSSFKQN HGNLCDNSLQ LQECREVGGG ASAASSMLPQ SVPTTPDIEN AELTPILPFL FLGNEQDAQD LDTMQRLNIG YVINVTTHLP LYHYEKGLFN YKRLPATDSN KQNLRQYFEE AFEFIEEAHQ CGKGLLIHCQ AGVSRSATIV IAYLMKHTRM TMTDAYKFVK GKRPIISPNL NFMGQLLEFE EDLNNGVTPR ILTPKLMGME TVV
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily. It preferably dephosphorylates p38.
基因功能參考文獻：
1. MKP-5 negatively regulates apoptotic signaling in skeletal muscle. During regeneration, MKP-5 downregulation contributes to myofiber survival. PMID: 29047406
2. MKP-5-mediated regulation of JNK negatively regulates phosphorylation of GRAB, which subsequently controls secretion of IL-6 PMID: 28096466
3. DUSP10 regulates intestinal epithelial cell growth and colorectal tumorigenesis. PMID: 25772234
4. In mouse macrophages, MKP-5 down-regulates the release of inflammatory mediators by controlling p38 MAPK activity PMID: 25615285
5. MAPK phosphotase 5 deficiency contributes to protection against blood-stage Plasmodium yoelii 17XL infection in mice. PMID: 24634491
6. MKP-5 is an essential negative regulator of the promyogenic actions of the MAPKs and may serve as a target to promote muscle stem cell function in the treatment of degenerative skeletal muscle diseases PMID: 23543058
7. MKP5 deficiency significantly reduces foam cell formation. PMID: 22683306
8. MKP5 is crucial to homeostatic regulation of MAPK activation in inflammatory responses. PMID: 22307906
9. a function for ASC that is distinct from the inflammasome in modulating MAPK activity and chemokine expression and further identify DUSP10 as a novel ASC target. PMID: 21487011
10. MKP5 has a principal function in both innate and adaptive immune responses, and represents a novel target for therapeutic intervention of immune diseases PMID: 15306813
11. The results show an earlier unrecognized and non-redundant function of MKP-5 in restraining p38 MAPK-mediated neutrophil oxidant production, thereby preventing lipopolysaccharide-induced vascular injury. PMID: 19696743
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亞細胞定位：

Cytoplasm. Nucleus.
蛋白家族：

Protein-tyrosine phosphatase family, Non-receptor class dual specificity subfamily
數據庫鏈接：

KEGG: mmu:63953

STRING: 10090.ENSMUSP00000045838

UniGene: Mm.404024