Recombinant Mouse Dipeptidyl peptidase 1 (Ctsc), partial

中文名稱(chēng)：

Recombinant Mouse Dipeptidyl peptidase 1(Ctsc),partial
貨號(hào)：

CSB-YP006186MO
規(guī)格：
來(lái)源：

Yeast
其他：

中文名稱(chēng)：

Recombinant Mouse Dipeptidyl peptidase 1(Ctsc),partial
貨號(hào)：

CSB-EP006186MO-B
規(guī)格：
來(lái)源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱(chēng)：

Recombinant Mouse Dipeptidyl peptidase 1(Ctsc),partial
貨號(hào)：

CSB-BP006186MO
規(guī)格：
來(lái)源：

Baculovirus
其他：

中文名稱(chēng)：

Recombinant Mouse Dipeptidyl peptidase 1(Ctsc),partial
貨號(hào)：

CSB-MP006186MO
規(guī)格：
來(lái)源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Ctsc
Uniprot No.：

P97821
別名：

CtscDipeptidyl peptidase 1; EC 3.4.14.1; Cathepsin C; Cathepsin J; Dipeptidyl peptidase I; DPP-I; DPPI; Dipeptidyl transferase) [Cleaved into: Dipeptidyl peptidase 1 exclusion domain chain; Dipeptidyl peptidase I exclusion domain chain); Dipeptidyl peptidase 1 heavy chain; Dipeptidyl peptidase I heavy chain); Dipeptidyl peptidase 1 light chain; Dipeptidyl peptidase I light chain)]
種屬：

Mus musculus (Mouse)
蛋白長(zhǎng)度：

Partial
表達(dá)區(qū)域：

25-134
氨基酸序列

DTPANC TYPDLLGTWV FQVGPRSSRS DINCSVMEAT EEKVVVHLKK LDTAYDELGN SGHFTLIYNQ GFEIVLNDYK WFAFFKYEVR GHTAISYCHE TMTGWVHDVL GRNW
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Thiol protease. Has dipeptidylpeptidase activity. Can act as both an exopeptidase and endopeptidase. Can degrade glucagon. Plays a role in the generation of cytotoxic lymphocyte effector function.
基因功能參考文獻(xiàn)：
1. Neutrophilic Cathepsin C Is Maturated by a Multistep Proteolytic Process and Secreted by Activated Cells during Inflammatory Lung Diseases. PMID: 26884336
2. A proteolytic cascade, involving cathepsins C and D, controls LLOMe-mediated necrosis. PMID: 25830414
3. CatC has a role in the selective tuning of innate and adaptive immune responses, relevant to a chronic immune disease, such as atherosclerosis. PMID: 25395616
4. Data indicate that all-trans retinoic acid (ATRA), which induces miR-23a expression, decreases cathepsin C (CTSC) expression and granzyme B activity leading to impaired NK cell cytotoxicity. PMID: 24440757
5. These results establish that DPPI is a major determinant of survival following Klebsiella pneumoniae lung infection and suggest that the survival disadvantage in DPPI(+/+) mice is in part due to processing of surfactant protein D by DPPI. PMID: 24955853
6. found no significant role for CtsC during mammary carcinogenesis but revealed squamous carcinogenesis to be functionally dependent on CtsC PMID: 24065739
7. Late stage cathepsin C, CXCL13 and Ki-67 overexpression correlate with regional neuropathology in a bovine spongiform encephalopathy transgenic murine model. PMID: 22789860
8. Proinflammatory cytokines induce expression and release of cathepsin C in microglial cells during neuroinflammatory progression. PMID: 22607609
9. The production of IL-1beta by macrophages, neutrophils, and mast cells in vitro is dependent on caspase-1 but not on cathepsin C. PMID: 22914048
10. NADPH oxidase in antimicrobial host defense against A. fumigatus and B. cepacia, whereas the proteases neutrophil elastase, cathepsin G, and lysosomal cysteine protease cathepsin C/ dipeptidyl peptidase I are dispensable PMID: 22163282
11. CatC is involved in limiting MCMV replication; however, this effect is independent of its role in promoting effector cytolytic activity. PMID: 20975734
12. Results indicate that mast cell dipeptidyl peptidase I (DPPI) harms the septic host and that DPPI is a novel potential therapeutic target for treatment of sepsis. PMID: 14966572
13. DPPI regulates a critical step in the development of collagen-induced arthritis that is independent of T cell and B cell functions. PMID: 16059912
14. Overall, our results indicate that although cathepsin C clearly generates the majority of granzyme B activity, some is still generated in its absence, pointing to alternative mechanisms for granzyme B processing and activation. PMID: 17283185
15. These findings suggest that DPPI and/or granule-associated serine proteases are necessary for neutrophil recruitment into the diseased aorta and that these proteases act to amplify vascular wall inflammation that leads to abdominal aortic aneurysms. PMID: 17301245
16. Role of DPPI and TIMP-3 in development of pulmonary fibrosis in early inflammation following bleomycin instillation. PMID: 17673693
17. DPPI is involved in recruitment of neutrophils following respiratory viral infection; absence of neutrophil-derived DPPI diminishes the acute inflammatory response and mucous cell metaplasia of the chronic asthma that follows Sendai virus infection. PMID: 18292580
18. Results indicate that DPPI cannot functionally compensate for the loss of TPPI. PMID: 18570628
19. Examination of mature enamel from DPPI null mice by FTIR showed no significant accumulation of protein; however, microhardness testing revealed that loss of DPPI expression significantly reduced enamel hardness. PMID: 19407151
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亞細(xì)胞定位：

Lysosome.
蛋白家族：

Peptidase C1 family
組織特異性：

Broadly distributed, but higher levels found in lung, liver, kidney and spleen. Lower levels found in testis and brain.
數(shù)據(jù)庫(kù)鏈接：

KEGG: mmu:13032

STRING: 10090.ENSMUSP00000032779

UniGene: Mm.322945