Recombinant Mouse Deoxyribonuclease-2-alpha (Dnase2)

中文名稱：

小鼠Dnase2重組蛋白
貨號：

CSB-YP007053MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Dnase2重組蛋白
貨號：

CSB-EP007053MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Dnase2重組蛋白
貨號：

CSB-EP007053MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Dnase2重組蛋白
貨號：

CSB-BP007053MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Dnase2重組蛋白
貨號：

CSB-MP007053MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Dnase2
Uniprot No.：

P56542
別名：

Dnase2; Dnase2a; Dnl2Deoxyribonuclease-2-alpha; EC 3.1.22.1; Acid DNase; Deoxyribonuclease II alpha; DNase II alpha; Lysosomal DNase II
種屬：

Mus musculus (Mouse)
蛋白長度：

Full Length of Mature Protein
表達區域：

20-353
氨基酸序列

L SCYGDSGQPV DWFVVYKLPA HSGSRDTPKG LTYKYMDQNS DGWQDGVGYI NSSEGAVGRS LQPLYRKNSS QLAFLLYNDQ PPKSSSARDS TGHGHTKGVL LLDQEGGFWL VHSVPRFPPP ASSGAYTWPP NAQTFGQTLL CVSLPFTQFA RIGKQLTYTY PLVYDHKLEG FFAQKLPDLE TVIKNQHVLH EPWNSSVILT SQAGATFQSF AKFGKFGDDL YSGWLAEALG TNLQVQFWQN SPGILPSNCS GAYQVLDVTQ TGFPGPSRLT FSATEDHSKW CVAPQGPWAC VGDMNRNKAE THRGGGTVCT QLPSFWKAFQ SLVKDWKPCI EGS
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the degradation of nuclear DNA in cellular apoptosis during development. Necessary for proper fetal development and for definitive erythropoiesis in fetal liver, where it degrades nuclear DNA expelled from erythroid precursor cells.
基因功能參考文獻：
1. holocrine secretion is a DNase2-mediated form of programmed cell death and suggest that autophagy-dependent metabolism, DNA degradation PMID: 27771328
2. Data show that Klf1 is expressed in central macrophagse of erythroblastic islands and that it binds and activates the promoter of Dnase2a. PMID: 21807894
相關疾病：

Absence of Dnase2 is a cause of severe fetal anemia and of perinatal lethality due to malformation of the diaphragm.
亞細胞定位：

Lysosome.
蛋白家族：

DNase II family
組織特異性：

Highly expressed in fetal liver macrophages.
數據庫鏈接：

KEGG: mmu:13423

STRING: 10090.ENSMUSP00000003910

UniGene: Mm.350831