Recombinant Mouse Dedicator of cytokinesis protein 5 (Dock5), partial

中文名稱：

小鼠Dock5重組蛋白
貨號：

CSB-YP007101MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Dock5重組蛋白
貨號：

CSB-EP007101MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Dock5重組蛋白
貨號：

CSB-EP007101MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Dock5重組蛋白
貨號：

CSB-BP007101MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Dock5重組蛋白
貨號：

CSB-MP007101MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Dock5
Uniprot No.：

B2RY04
別名：

Dock5; Lr2; RlcDedicator of cytokinesis protein 5; Lens rupture protein 2; Rupture of lens cataract protein
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Guanine nucleotide exchange factor (GEF) for Rho and Rac. GEF proteins activate small GTPases by exchanging bound GDP for free GTP. Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen.
基因功能參考文獻：
1. Dock5 and tensin 3 cooperate for osteoclast activity, to ensure the correct organization of podosomes. PMID: 27505886
2. Tensin3 is a versatile regulator of DOCK5 signaling and cell adhesion. (Review) PMID: 27748980
3. together with DOCK2 contributes to chemotaxis, reactive oxygen species production, and extracellular trap formation PMID: 25339677
4. Dock1 and Dock5 are not the important exchange factors regulating Rac activity during the establishment and maintenance of the glomerular barrier PMID: 24365888
5. results thus identify DOCK5 as a key signaling adaptor that orchestrates remodeling of the microtubule network essential for mast cell degranulation. PMID: 24913231
6. The atypical Rac1 exchange factor Dock5 is necessary for osteoclast function both in vitro and in vivo. PMID: 21542010
7. Generated an mDock5-specific antibody, which detected denatured and nascent forms of mDock5. Determined tissue-specific expression patterns and subcellular localization of mDock5 using this antibody. PMID: 19995334
8. Cataract causing lr2 gene is found in the CXSD mouse, which is a recombinant inbred strain of BALB/c and STS mice PMID: 15297702
9. Dock5 is dispensable for normal mouse embryogenesis and contribution of Dock5 toward myofiber development. PMID: 18820033
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相關疾病：

Defects in Dock5 are the cause of rupture of lens cataract. It affects both eyes and is inherited as an autosomal recessive trait. Homozygotes spontaneously develop opacity of the lens at 35-60 days of age. The initial pathological changes appear at about 35 days of age in the deep layer of the posterior cortex as irregular swelling, condensation, degeneration and fragmentation of the lens fibers, leading to rupture of the lens capsule at the posterior pole at 45-100 days of age. Following rupture, the lens nucleus becomes dislocated behind the lens or occasionally in the anterior chamber.
亞細胞定位：

Cytoplasm. Cell membrane.
蛋白家族：

DOCK family
組織特異性：

Highly expressed in lens, where it predominantly localizes to anterior epithelial cells, and is weakly expressed in lens fiber (at protein level). Expressed in brain, eye, lung, spleen and kidney, but not in thymus or peripheral blood leukocytes.
數據庫鏈接：

KEGG: mmu:68813

STRING: 10090.ENSMUSP00000036674

UniGene: Mm.258155