Recombinant Mouse DNA-directed RNA polymerase III subunit RPC5 (Polr3e)

中文名稱：

小鼠Polr3e重組蛋白
貨號(hào)：

CSB-YP861500MO
規(guī)格：
來源：

Yeast
其他：

中文名稱：

小鼠Polr3e重組蛋白
貨號(hào)：

CSB-EP861500MO
規(guī)格：
來源：

E.coli
其他：

中文名稱：

小鼠Polr3e重組蛋白
貨號(hào)：

CSB-EP861500MO-B
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Polr3e重組蛋白
貨號(hào)：

CSB-BP861500MO
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Polr3e重組蛋白
貨號(hào)：

CSB-MP861500MO
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Polr3e
Uniprot No.：

Q9CZT4
別名：

Polr3e; Sin; DNA-directed RNA polymerase III subunit RPC5; RNA polymerase III subunit 5; RNA polymerase III subunit C5; Sex-lethal interactor homolog; Sxl interactor
種屬：

Mus musculus (Mouse)
蛋白長(zhǎng)度：

full length protein
表達(dá)區(qū)域：

1-710
氨基酸序列

MANEEDDPVI QEIDVYLAKS LAEKLYLFQY PVRPASMTYD DIPHLSAKIK PKQQKVELEM AIDTLNPNYC RSKGEQIALN VDGACADETS TYSSKLMDKQ TFCSSQTTSN TARYAAALYR QGELHLTPLH GILQLRPSFS YLDKADAKHR EREAANEAGD SSQDEAEEDV KQITVRFSRP ESEQARQRRV QSYEFLQKKH AEEPWVHLHY YGMRDSRSEH ERQYLLCQGS SGVENTELVK SPSEYLMMLM PPSPEEEKDK PVAPSNVLSM AQLRTLPLAD QIKVLMKNVK VMPFANLMSL LGPSVDSVAV LRGIQKVAML VQGNWVVKSD ILYPKDSSSP HSGMPAEVLC RGRDFVMWKF TQSRWVVRKE VAAVTKLCAE DVKDFLEHMA VVRINKGWEF LLPYDLEFIK KHPDVVQRQH MLWSGIQAKL EKVYNLVKET MPKKPDGQSA PVGLVSGEQR VQTAKTKAQQ NHAFLERELQ RRKEQMRAAT VLPSVQIKEE PLSEEEADGA ELEAEEEEPM DTAPSTCLST KLANGLPAGR AVGGDSLNGH PVPGCASNPV ACELKAFVEA TFQRQFVLTL SELKRLFNLH LAGLPPGHIL FSGVSDRMLQ DTVLAAGCKQ ILVPFPPQTA ASPDEQKVFA LWESGDMSDQ HRQVLLEIFS KNYRVRRNLI QSRLTQECGE ELSKQEVDKV LKDCCVSCGG MWYLKGTVQS
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific periphjeric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Essential for efficient transcription from both the type 2 VAI and type 3 U6 RNA polymerase III promoters. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa-B through the RIG-I pathway.
基因功能參考文獻(xiàn)：
1. a mammalian interspersed repeat (MIR) nested in antisense orientation within the first intron of the Polr3e gene, affects Polr3e expression through transcriptional interference PMID: 28289142
2. Results identify Sin as a novel regulator of medullary thymic epithelial cell development and t cell tolerance. PMID: 20404100
亞細(xì)胞定位：

Nucleus.
數(shù)據(jù)庫(kù)鏈接：

KEGG: mmu:26939

STRING: 10090.ENSMUSP00000033173

UniGene: Mm.193632