1. In p22phox(-/-) mice, hypoxic pulmonary vasoconstriction (HPV) was significantly impaired. In the chronic hypoxic setting, lack of p22phox was associated with improved right ventricular function and decreased pulmonary vascular remodelling. PMID: 28729471
2. Together with the increased p22phox expression in lungs of asthmatic patients, findings demonstrate a crucial role of p22phox-dependent NADPH oxidase for the development of mucus hypersecretion and airway hyperresponsiveness in house dust mite-induced model of asthma. PMID: 28510479
3. Identification of a PPAR-gamma --> NF-kappaB --> p22phox neuroprotective signaling cascade opens a new avenue for protecting the brain against ischemic insult. PMID: 26108185
4. Knockout of the cytochrome P450 reductase by CRISPR/Cas9 technology (POR(-/-)) in HEK293 cells overexpressing Nox4 or Nox5 did not interfere with ROS production in intact cells. However, POR(-/-) abolished the signal in NADPH-stimulated assays using membrane fractions from the very same cells. Moreover, membranes of rat smooth muscle cells treated with angiotensin II showed an increased NADPH-dependent signal with lucigen PMID: 27863990
5. p22phox mRNA expression was increased in diet-induced obese (DIO) mice. PMID: 26297224
6. The present study provides evidence that augmented EGFRtk impairs vascular function by NADPH oxidase-dependent mechanism. Therefore, EGFRtk and oxidative stress should be potential targets to treat vascular dysfunction in TD2. PMID: 26036345
7. Vascular hnRNP-C expression is regulated by ROS derived from NADPH oxidases and that the effects of NADPH oxidase on vascular activation are mediated in part by protein kinase CK1alpha. PMID: 24035466
8. Enhanced p22(phox) expression causes vascular dysfunction through ERK1/2 and p38-mitogen-activated protein kinase-dependent mechanisms in male type 2 diabetic mice. PMID: 24486509
9. The first quantitative characterization of the interactions made between the cytosolic regulators NOXO1 and NOXA1 and membrane-bound p22(phox), is presented. PMID: 20454568
10. renal expression of Nox-2, p22(phox), and p47(phox), components of NADPH oxidase, are upregulated in GSD-Ia mice compared with controls PMID: 20195241
11. cytochrome b558 expression is downregulated via the reduction of heme availability after NADPH oxidase is inhibited by HO-1 PMID: 15123630
12. role in resistance to mucosal and systemic candidiasis of endogenous origin PMID: 15731028
13. LPS treatment enhanced protein levels of p22(phox), a catalytic subunit of NADPH oxidase, and increased NADPH oxidase activity and levels of superoxide radicals and hydrogen peroxide. PMID: 16973969
14. p22phox expression was increased during glucose-induced oxidative stress in microvascular endothelial cells. PMID: 17443690
15. collagen synthesis in cardiac fibroblasts involves a facilitative interaction between TGFbeta(1)-NADPH oxidase and LOX-1 PMID: 18182394
16. mice of the nmf333 strain, animal model of p22(phox) deficiency, exhibit a compound phenotype consisting of both a CGD-like immune defect and a balance disorder caused by the aberrant development of gravity-sensing organs. PMID: 18292807
17. Suggest that a NOX4 isotype plus p22 phox account for the swelling-induced increase in the reactive oxygen species production in NIH3T3 cells. PMID: 18417717
18. p22phox is expressed in the retinal pigment epithelial cells and inner retinal neurons. A small-interfering RNA designed against p22phox efficiently reduced the expression of the protein in the eye when delivered by recombinant adeno-associated virus PMID: 18665154
19. Chronic intermittent hypoxia-induced pulmonary hypertension was associated with increased lung levels of the NADPH oxidase subunits, Nox4 and p22phox. PMID: 18952568
20. p22phox is involved in invadopodia formation; Tks5 and p22(phox) can associate with each other, suggesting that Tks5 is part of the Nox complex PMID: 19755709

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KEGG: mmu:13057

STRING: 10090.ENSMUSP00000017604

UniGene: Mm.271671