Recombinant Mouse Complement component receptor 1-like protein (Cr1l), partial

^{In
Stock}

中文名稱：

Recombinant Mouse Complement component receptor 1-like protein(Cr1l),partial
品名簡稱：

Recombinant Mouse Cr1l protein, partial
貨號：

CSB-EP717575MO1
說明書：

MSDS Datasheet
規(guī)格：

￥1836
圖片：
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP717575MO1 could indicate that this peptide derived from E.coli-expressed Mus musculus (Mouse) Cr1l.

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP717575MO1 could indicate that this peptide derived from E.coli-expressed Mus musculus (Mouse) Cr1l.
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

純度：

Greater than 85% as determined by SDS-PAGE.
基因名：

Cr1l
Uniprot No.：

Q64735
別名：

Cr1l; Crry; CryComplement component receptor 1-like protein; Complement regulatory protein Crry; Protein p65
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
來源：

E.coli
分子量：

44.5 kDa
表達區(qū)域：

41-405aa
氨基酸序列

ELRGGLGKHGHTVHREPAVNRLCADSKRWSGLPVSAQRPFPMGHCPAPSQLPSAKPINLTDESMFPIGTYLLYECLPGYIKRQFSITCKQDSTWTSAEDKCIRKQCKTPSDPENGLVHVHTGIQFGSRINYTCNQGYRLIGSSSAVCVITDQSVDWDTEAPICEWIPCEIPPGIPNGDFFSSTREDFHYGMVVTYRCNTDARGKALFNLVGEPSLYCTSNDGEIGVWSGPPPQCIELNKCTPPPYVENAVMLSENRSLFSLRDIVEFRCHPGFIMKGASSVHCQSLNKWEPELPSCFKGVICRLPQEMSGFQKGLGMKKEYYYGENVTLECEDGYTLEGSSQSQCQSDGSWNPLLAKCVSRSISG
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 6xHis-tagged
產(chǎn)品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Tris-based buffer,50% glycerol
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

3-7 business days
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. Also acts as a decay-accelerating factor, preventing the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade. Plays a crucial role in early embryonic development by maintaining fetomaternal tolerance. Also acts as a costimulatory factor for T-cells which favors IL-4 secretion.
基因功能參考文獻：
1. CRRY role in the retinal epithelium and photoreceptor degeneration PMID: 28348233
2. this study has provided direct evidence for a role of Crry in controlling spontaneous alternative pathway complement activation on renal tubular epithelial cells. PMID: 24850152
3. Crry costimulation enhanced the in vitro expansion of natural Treg cells while maintaining their phenotypic and suppressive properties. Crry-expanded Treg cells decreasing antigen-dependent secretion of cytokines. PMID: 21380996
4. Stmn2 and the chromosome 14 Rarb region, but not Cr1 or Clu or Picalm, have roles in prion disease. PMID: 21151910
5. Crry is clearly present in the placentas from spontaneous abortions in mice. PMID: 20484840
6. Crry is the only membrane-bound complement regulator expressed on the basolateral surface of murine renal tubular epithelial cells under in vitro culture conditions. PMID: 20675597
7. Data show that a single-nucleotide polymorphism in the first short consensus repeat of Sle1c Crry introduced a novel N-linked glycosylation site likely responsible for structural alteration. PMID: 20660348
8. mesangial cell Crry limits complement activation and subsequent neutrophil recruitment in the setting of local immune complex deposition. PMID: 19740350
9. Long-term complement blockade with Crry, a C3 convertase inhibitor overexpressed in a transgenic mouse line, reduces renal disease and improves survival in lupus-prone MRL/lpr mice. PMID: 11907125
10. the role of crry in regulating complement regulation PMID: 11915940
11. Crry is indispensable for erythrocyte protection from spontaneous complement attack PMID: 11986227
12. Crry plays a more dominant role than DAF in regulating the alternative pathway of complement C3 activation, whereas DAF and Crry are equally effective in preventing antibody-induced runaway complement activation. PMID: 12393518
13. X-ray and neutron scattering was performed on recombinant rat Crry containing the first five SCR domains (rCrry) and mouse Crry with five SCR domains conjugated to the Fc fragment of mouse IgG1 (mCrry-Ig) PMID: 12767833
14. Mice transgenic for murine complement inhibitor Crry are largely protected from developing collagen-induced arthritis. PMID: 12902517
15. Data demonstrate that transgenic mice with astrocyte-targeted expression of the soluble complement inhibitor sCrry have a significantly reduced neurologic impairment and improved blood-brain barrier function after closed head injury. PMID: 12973023
16. The dual function of Crry as a complement regulatory protein and as a T cell costimulator illustrates the importance of complement regulatory proteins as links between innate and adaptive immunity. PMID: 16301324
17. Results suggest that altered expression of Crry within the tubular epithelium appears to be a critical factor permitting activation of the alternative pathway of complement after ischemia/reperfusion. PMID: 16444293
18. both a high level expression and a more potent anti-alternative pathway complement activity of Crry contributed to its indispensable role on murine erythrocytes PMID: 17015743
19. Our data suggest complement provides some protection of mature oligodendrocytes during cuprizone treatment but may be critical for subsequent remyelination events. PMID: 17674370
20. DAF and Crry double deficiency led to rapid clearance of platelets from circulation in a complement- and macrophage-dependent manner; redundant role of DAF and Crry in platelet survival PMID: 18524992
21. Membrane complement regulator Crry helps to maintain homeostasis of the complement alternative pathway (AP) and demonstrates that Crry-deficient mice can be rescued on a partial as well as on a complete factor B- or C3-deficient maternal background. PMID: 18684964
22. Pak1 is an essential molecular target for modulating acute mast cell responses that contribute to allergic diseases. PMID: 19124833
23. Crry is essential for mature T-cell survival in the periphery but not for lymphogenesis in the thymus. PMID: 19136662
24. Crry and CD59 are critical in protecting Treg cells from complement mediated injuries. PMID: 19281793
顯示更多

收起更多
亞細胞定位：

Membrane; Single-pass type I membrane protein.
蛋白家族：

Receptors of complement activation (RCA) family
組織特異性：

Ubiquitously expressed (at protein level).
數(shù)據(jù)庫鏈接：

KEGG: mmu:12946

UniGene: Mm.301652