Recombinant Mouse Coagulation factor V (F5), partial

中文名稱：

小鼠F5重組蛋白
貨號：

CSB-YP007929MO
規(guī)格：
來源：

Yeast
其他：

中文名稱：

小鼠F5重組蛋白
貨號：

CSB-EP007929MO
規(guī)格：
來源：

E.coli
其他：

中文名稱：

小鼠F5重組蛋白
貨號：

CSB-EP007929MO-B
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠F5重組蛋白
貨號：

CSB-BP007929MO
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

小鼠F5重組蛋白
貨號：

CSB-MP007929MO
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

F5
Uniprot No.：

O88783
別名：

F5Coagulation factor V; Activated protein C cofactor) [Cleaved into: Coagulation factor V heavy chain; Coagulation factor V light chain]
種屬：

Mus musculus (Mouse)
蛋白長度：

partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin.
基因功能參考文獻：
1. Mice with the FVL mutation do not have increased spermatogenesis as compared to wildtype mice. PMID: 28927238
2. Platelet-derived FV is a critical mediator of arterial thrombosis that involves platelet activation. PMID: 28673898
3. Platelet-derived FV contributes to the control of angiogenesis and is likely associated with thrombin generation in hind limb ischemia model. PMID: 27237401
4. Mice deficient in LMAN1 exhibit FV and FVIII deficiencies and liver accumulation of alpha1-antitrypsin. PMID: 21795745
5. The FVL mutation does not influence coagulation activation, lung inflammation or survival in lethal influenza A. PMID: 20413539
6. It suggested that there could be a combination of GLA deficiency and FVL or other thrombosis-related gene defect in patients with genetic severe early-onset thrombosis. PMID: 20533258
7. that the murine platelet FV compartment is derived exclusively from primary biosynthesis within cells of marrow origin and an intact platelet FV pool is not required for protection from spontaneous hemorrhage or bleeding following minor trauma PMID: 12816857
8. the murine platelet and plasma FV pools are biosynthetically distinct PMID: 12855561
9. The source of the FVL leading to accelerated thrombosis appears to be circulating, non-platelet-derived plasma FVL. PMID: 15809370
10. FVL has the ability to improve the hemophilia A or B phenotype, but this effect is principally evident at the microcirculation level following a particular vascular injury. PMID: 16359510
11. observations demonstrate a synergistic interaction between alpha-galactosidase A deficiency and Factor V Leiden toward tissue fibrin deposition; concomitant mutations in these genes may increase the penetrance of vascular thrombotic events in humans PMID: 16514103
12. Fetal gene defects precipitate platelet-mediated pregnancy failure in factor V Leiden mothers. PMID: 17438064
13. The FVL mutation has no effect on the development of secondary tumours of colon cancer in livers of mice. PMID: 17635646
14. FV Leiden allele has no effect in murine colitis and we thus question the importance of activated blood coagulation in the etiology or pathogenesis of inflammatory bowel disease. PMID: 17849058
15. the factor V Leiden mutation is associated with enhanced thrombotic tendency after FeCl3 injury of the femoral artery on a standard fat diet, but not a high fat diet PMID: 17938812
16. In contrast to humans, pregnancy induced a decrease in APC resistance in wild-type and in FV Leiden mice. PMID: 19036061
17. Homozygous Factor V could promote atherosclerosis and fibrin deposition in apolipoprotein E deficient mice. PMID: 19671356
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亞細胞定位：

Secreted.
蛋白家族：

Multicopper oxidase family
數(shù)據(jù)庫鏈接：

KEGG: mmu:14067

STRING: 10090.ENSMUSP00000083204

UniGene: Mm.12900