Recombinant Mouse Cell division cycle 7-related protein kinase (Cdc7)

中文名稱：

Recombinant Mouse Cell division cycle 7-related protein kinase(Cdc7)
貨號：

CSB-YP897068MO
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Mouse Cell division cycle 7-related protein kinase(Cdc7)
貨號：

CSB-EP897068MO
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Mouse Cell division cycle 7-related protein kinase(Cdc7)
貨號：

CSB-EP897068MO-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Mouse Cell division cycle 7-related protein kinase(Cdc7)
貨號：

CSB-BP897068MO
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Mouse Cell division cycle 7-related protein kinase(Cdc7)
貨號：

CSB-MP897068MO
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Cdc7
Uniprot No.：

Q9Z0H0
別名：

Cdc7; Cdc7l1Cell division cycle 7-related protein kinase; CDC7-related kinase; muCdc7; EC 2.7.11.1
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達區域：

1-564
氨基酸序列

MEEPMAFSSL RGSDRCPADD SLKKYEQSVK LSGIKRDIEE LCEAVPQLVN VFKIKDKIGE GTFSSVYLAT AQLQEGHEEK IALKHLIPTS HPMRIAAELQ CLTVAGGQDN VMGLKYCFRK NDHVVIAMPY LEHESFLDIL NSLSFQEVRE YMYNLFVALK RIHQFGIVHR DVKPSNFLYN RRLKKYALVD FGLAQGTRDT KIELLKFVQS EAQQEDCSRN KYHGVVGHKG LLSRPAPKTV DQQCTPKTSV KRSYTQVHIK QGKDGKERSV GLSVQRSVFG ERNFNIHSSI SHESPAEKLI KQSKTVDIIS RKLATKKTAI STKAMNSVMR ETARSCPAVL TCDCYGSDRV CSVCLSRRQQ VAPRAGTPGF RAPEVLTKCP DQTTAIDMWS AGVIFLSLLS GRYPFYKASD DLTALAQIMT IRGSRETIQA AKAFGKSVLC SKEVPAQDLR ALCERLRGLD STTPRSASGP PGNASYDPAA SKNTDHKASR VQAAQAQHSE DSLYKRDNDG YWSHPKDCTS NSEGWDSVPD EAYDLLDKLL DLNPASRITA EAALLHAFFK DMCS
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Seems to phosphorylate critical substrates that regulate the G1/S phase transition and/or DNA replication. Can phosphorylate MCM2 and MCM3.
基因功能參考文獻：
1. Results suggest a new role of Claspin in initiation of DNA replication during normal S phase through the recruitment of Cdc7 that facilitates phosphorylation of Mcm proteins. PMID: 27401717
2. Increased Cdc7-dependent replication initiation is a hallmark of p53 gain-of function mutations in lung adenocarcinoma. PMID: 28887320
3. Cdc7 physically and functionally interacts with Nkx2.5 to regulate Myocd promoter activity PMID: 24133205
4. Cdc7 mediates SMC differentiation through a mechanism distinct from cell proliferation. PMID: 22223649
亞細胞定位：

Nucleus.
蛋白家族：

Protein kinase superfamily, Ser/Thr protein kinase family, CDC7 subfamily
數據庫鏈接：

KEGG: mmu:12545

STRING: 10090.ENSMUSP00000031221

UniGene: Mm.20842