Recombinant Mouse Cell division control protein 6 homolog (Cdc6)

中文名稱：

Recombinant Mouse Cell division control protein 6 homolog(Cdc6)
貨號：

CSB-YP005022MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Mouse Cell division control protein 6 homolog(Cdc6)
貨號：

CSB-EP005022MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Mouse Cell division control protein 6 homolog(Cdc6)
貨號：

CSB-EP005022MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Mouse Cell division control protein 6 homolog(Cdc6)
貨號：

CSB-BP005022MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Mouse Cell division control protein 6 homolog(Cdc6)
貨號：

CSB-MP005022MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Cdc6
Uniprot No.：

O89033
別名：

Cdc6Cell division control protein 6 homolog; CDC6-related protein; p62(cdc6)
種屬：

Mus musculus (Mouse)
蛋白長度：

Full length protein
表達區域：

1-562
氨基酸序列

MPQTRSQTQA TIGFPKKKLS NTLKKPNSRD CEVKLRNVQP VPTTPCVDVK LLPLSPRKRL GDDNLCNTPR LSPCSPPKLG KKENGPPRSH TWKGCRLVFD DEPTFKASPP KEQDRVRQHQ IRSSSAQRSP ESKADPEQKC PPEKESVCIR LFKQEGTCYQ QAKLVLNTAV PDRLPAREQE MGVIRNFLKE HICGKKAGSL YLSGAPGTGK TACLSRILQD FKKEVKGFKS ILLNCMSLRS AQAVFPAIAQ EIGREELCRP AGKDLMRKLE KHLTAEKGPM IVLVLDEMDQ LDSKGQDVLY TLFEWPWLSN SRLVLIGIAN TLDLTDRILP RLEARENCKP QLLNFPPYTR NQIAAILQDR LSQVSKDQVL DSAAIQFCAR KVSAVSGDIR KALDVCRRAI EIVESDVRSQ TVLKPLSECK SPSESPVPKR VGLAHISQVI SEVDGNRVTL SQENTQDSLP LQQKILVCSL LLLTRRLKIK EVTLGKLYEA YSSICRKQQV TAVDQSECLS LSGLLESRGL VGLKKNKESR LTKVSLKIEE KEIEHVLNGK AFTGNILAAG LP
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.
基因功能參考文獻：
1. Dele and Cdc6 G-quadruplex formation is significant in the transcriptional regulation. Dele and Cdc6 G-quadruplex DNA alone possess enhancer and promotor function. PMID: 28655335
2. CDK1 activation proceeds with concomitant inhibition by CDC6, which tunes the timing of the M-phase entry during the embryonic cell cycle PMID: 25264619
3. Cdc6 continued to block apoptosome assembly induced by a non-cytochrome c or some other mechanism, suppressing seemingly unintended apoptosis when promoting cell proliferation PMID: 22493447
4. show that MyoD can occupy an E-box within the promoter of Cdc6 and that this association, along with E2F3a, is required for its activity. PMID: 20048262
5. CDC6 is essential for spindle formation in mouse oocytes PMID: 15385409
6. hCdt1 and hCdc6 expression promote malignant behavior PMID: 18006835
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亞細胞定位：

Nucleus. Cytoplasm.
蛋白家族：

CDC6/cdc18 family
數據庫鏈接：

KEGG: mmu:23834

STRING: 10090.ENSMUSP00000091469

UniGene: Mm.20912