Recombinant Mouse Calsequestrin-1 (Casq1)

中文名稱：

Recombinant Mouse Calsequestrin-1(Casq1)
貨號：

CSB-YP004556MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Mouse Calsequestrin-1(Casq1)
貨號：

CSB-EP004556MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Mouse Calsequestrin-1(Casq1)
貨號：

CSB-EP004556MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Mouse Calsequestrin-1(Casq1)
貨號：

CSB-BP004556MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Mouse Calsequestrin-1(Casq1)
貨號：

CSB-MP004556MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Casq1
Uniprot No.：

O09165
別名：

Casq1Calsequestrin-1; Calmitine; Calsequestrin; skeletal muscle isoform
種屬：

Mus musculus (Mouse)
蛋白長度：

Full Length of Mature Protein
表達區域：

35-405
氨基酸序列

EDGLDF PEYDGVDRVI NVNAKNYKNV FKKYEVLALL YHEPPEDDKA SQRQFEMEEL ILELAAQVLE DKGVGFGLVD SEKDAAVAKK LGLTEEDSVY VFKGDEVIEY DGEFSADTLV EFLLDVLEDP VELIEGEREL QAFENIEDEI KLIGYFKSKD SEHYKAYEDA AEEFHPYIPF FATFDSKVAK KLTLKLNEID FYEAFMEEPM TIPDKPNSEE EIVSFVEEHR RSTLRKLKPE SMYETWEDDL DGIHIVAFAE EADPDGYEFL ETLKAVAQDN TENPDLSIIW IDPDDFPLLV PYWEKTFDID LSAPQIGVVN VTDADSIWME MDNEEDLPSA DELEDWLEDV LEGEINTEDD DDDDDDDDDD DDDDD
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, often at the interface between subunits. Can bind around 80 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR1; this plays an important role in triggering muscle contraction. Negatively regulates store-operated Ca(2+) entry (SOCE) activity.
基因功能參考文獻：
1. Authors hypothesize that the protective effect of aerobic training is essentially mediated by a reduction in oxidative stress during exposure of CASQ1-null mice to adverse environmental conditions. PMID: 29849896
2. These results suggest that common molecular mechanisms underlie malignant hyperthermia (MH) crises and exertional HS in mice.- PMID: 28465322
3. Calcium entry activated by ablation of both JP45-CASQ1 and JP45-CASQ2 complexes supports tetanic force development in slow twitch soleus muscles. PMID: 27189940
4. Transient knockdown of annexin A6 and calsequestrin 1 protein of high-active mice with vivo-morpholinos resulted in decreased physical activity levels (P = 0.001). PMID: 24505100
5. results support the view that in skeletal muscles, CASQ1 plays a key role in both Ca(2+) homeostasis and terminal cisternae structure PMID: 22049211
6. The results presented in this paper unmask a differential effect of CASQ1&2 ablation in fast versus slow fibers PMID: 21941434
7. Calsequestrin not only stores Ca(2+), but also varies its affinity in ways that progressively increase the ability of the store to deliver Ca(2+) as it becomes depleted, a novel feedback mechanism of potentially valuable functional implications. PMID: 20713548
8. effect of nockdown of CSQ1 in adult mouse skeletal muscle on Store-operated Ca(2+) entry PMID: 20816068
9. knocking down CSQ2, but not CSQ1, leads to reduced Ca2+ storage and release in C2C12 myotubes PMID: 16595676
10. CSQ1 is essential for the normal development of the sarcoplasmic reticulum (SR) and its calcium release units and for the storage and release of appropriate amounts of SR Ca(2+). PMID: 17627988
11. Data report that calsequestrin-1-null mice exhibit increased spontaneous mortality and susceptibility to heat- and anesthetic-induced sudden death, and show that CASQ1 deficiency alters proper control of ryanodine receptor function. PMID: 19237502
12. In dystrophin-deficient mdx mice the calsequestrin is overpression in laryngeal muscles. PMID: 19301368
13. ablation of CASQ1 results in malignant hyperthermia- and exertional/environmental heat stroke-like lethal episodes PMID: 19417098
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亞細胞定位：

Endoplasmic reticulum. Sarcoplasmic reticulum. Sarcoplasmic reticulum lumen. Sarcoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side. Mitochondrion matrix.
蛋白家族：

Calsequestrin family
組織特異性：

Detected in skeletal muscle (at protein level). Detected in skeletal muscle.
數據庫鏈接：

KEGG: mmu:12372

STRING: 10090.ENSMUSP00000003554

UniGene: Mm.12829