Recombinant Mouse CLIP-associating protein 2 (Clasp2), partial

中文名稱：

Recombinant Mouse CLIP-associating protein 2(Clasp2) ,partial
貨號：

CSB-YP806424MO
規(guī)格：
來源：

Yeast
其他：

中文名稱：

Recombinant Mouse CLIP-associating protein 2(Clasp2) ,partial
貨號：

CSB-EP806424MO
規(guī)格：
來源：

E.coli
其他：

中文名稱：

Recombinant Mouse CLIP-associating protein 2(Clasp2) ,partial
貨號：

CSB-EP806424MO-B
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Mouse CLIP-associating protein 2(Clasp2) ,partial
貨號：

CSB-BP806424MO
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Mouse CLIP-associating protein 2(Clasp2) ,partial
貨號：

CSB-MP806424MO
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
靶點詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Clasp2
Uniprot No.：

Q8BRT1
別名：

Clasp2; Kiaa0627; CLIP-associating protein 2; Cytoplasmic linker-associated protein 2
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex.
基因功能參考文獻(xiàn)：
1. The novel protein SOGA1 was confirmed to colocalize with a microtubule-associated protein CLASP2 and with tubulin, which identifies SOGA1 as a new microtubule-associated protein. PMID: 28550165
2. data reveal that CLASP2 is an essential Reelin effector orchestrating cytoskeleton dynamics during brain development. PMID: 28285824
3. These findings reveal a new role for Clasp2 in governing keratinocyte undifferentiated features. PMID: 28069833
4. A transport system, organized by agrin through PI3 kinase, GSK3beta, CLASP2, and LL5beta, for precise delivery of acetylcholine receptor vesicles from subsynaptic nuclei to overlying synaptic membrane was identified at neuromuscular junction membrane. PMID: 25589673
5. the functional relationship between Abl and CLASP2 is conserved and provides a means to control the CLASP2 association with the cytoskeleton. PMID: 24520051
6. The MT plus end-binding protein CLASP2 localizes to adherens junctions (AJs) via direct interaction with p120-catenin (p120) in primary basal mouse keratinocytes. PMID: 24368809
7. CLASP2 is required for the proper attachment of fibroblasts, HSC-enriched cells, and platelets, indicating a general role for this protein in cell attachment. PMID: 23084744
8. CLASP2 directs the delivery of GLUT4 to cell cortex landing zones important for insulin action PMID: 22992739
9. Short-hairpin RNA-mediated CLASP2 knockdown in mouse neurons decreases axon & dendritic length. It is involved in cytoskeleton-related neuronal polarity & interplay between microtubule stabilization & synapse formation & activity. PMID: 23035100
10. the cascade linking agrin to CLASP2-mediated microtubule capturing at the synaptic membrane is essential for the maintenance of a normal neuromuscular phenotype PMID: 22851317
11. Together, our data support that the partial redundancy of CLASPs during mitosis acts as a possible mechanism to prevent aneuploidy in mammals. PMID: 16914514
12. Regional immobilization of CLASP2 allows MT stabilization and promotes directionally persistent motility in fibroblasts. PMID: 17113391
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亞細(xì)胞定位：

Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Golgi apparatus. Golgi apparatus, trans-Golgi network. Cell membrane. Cell projection, ruffle membrane.
蛋白家族：

CLASP family
組織特異性：

Highly expressed in brain and at low levels in heart, kidney and lung.
數(shù)據(jù)庫鏈接：

KEGG: mmu:76499

STRING: 10090.ENSMUSP00000130201

UniGene: Mm.222272