Recombinant Mouse Brevican core protein (Bcan), partial

中文名稱：

Recombinant Mouse Brevican core protein(Bcan) ,partial
貨號(hào)：

CSB-YP733783MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

Recombinant Mouse Brevican core protein(Bcan) ,partial
貨號(hào)：

CSB-EP733783MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
其他：

中文名稱：

Recombinant Mouse Brevican core protein(Bcan) ,partial
貨號(hào)：

CSB-EP733783MO-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Mouse Brevican core protein(Bcan) ,partial
貨號(hào)：

CSB-BP733783MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Mouse Brevican core protein(Bcan) ,partial
貨號(hào)：

CSB-MP733783MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Bcan
Uniprot No.：

Q61361
別名：

Bcan; Brevican core protein
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans.
基因功能參考文獻(xiàn)：
1. intrachromosomal deletion generating a fusion between BCAN and NTRK1 drives the formation of aggressive high-grade gliomas and confers sensitivity to entrectinib PMID: 28695888
2. The synaptic plasticity occurs in the hippocampus of freely behaving mice that lack brevican, the informational content stored by synaptic plasticity is not the same. PMID: 28512860
3. This study found that mice with reduced brevican levels show enhanced locomotor activity to acute cocaine and a progressive increase in expression of cocaine CPP during forced abstinence. PMID: 26711251
4. The extracellular matrix molecule brevican is an integral component of the machinery mediating fast synaptic transmission at the calyx of Held PMID: 26223835
5. This study provided evidence that the brevican modulates synaptogenesis and long-term synapse stability. The mutant neurons display reduced frequencies of mEPSCs and mIPSCs. PMID: 23637166
6. these results imply that Bral2-brevican interaction may play a key role in synaptic stabilization and the structural integrity of brain perineuronal nets PMID: 22121037
7. defective brevican processing observed in amyloid beta-bearing mice may contribute to deficient neural plasticity PMID: 20180882
8. Results indicate that reactive gliosis differs between the spinal cord dorsal root entry zone and dorsal column and that Brevican and Versican may participate in the inhibitory properties of the dorsal root entry zone. PMID: 19683574
9. Brevican is not essential for learning and memory, but plays a role in long-term potentiation in mice PMID: 12370289
10. Brevican and the ADAMTS-cleaved fragment of brevican were most broadly distributed in neuropil in the brain. PMID: 18221525
11. The proteoglycan brevican binds to fibronectin after proteolytic cleavage and promotes glioma cell motility PMID: 18611854
12. This study show that brevican plays a crucial role in determining the specialization of the hyaluronan-binding nodal matrix assemblies in large diameter nodes. PMID: 19141078
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亞細(xì)胞定位：

Secreted, extracellular space, extracellular matrix.
蛋白家族：

Aggrecan/versican proteoglycan family
組織特異性：

Expressed in the retina, specifically around the inner and outer segments of photoreceptors, retinal pigment epithelium, outer plexiform layer, and the ganglion cell layer (at protein level). Brain.
數(shù)據(jù)庫鏈接：

KEGG: mmu:12032

STRING: 10090.ENSMUSP00000088491

UniGene: Mm.4598