1. Suggest a crucial role for ST6Gal1 in elevating the invasiveness of pancreatic ductal adenocarcinoma cells in a fructose-responsive manner. PMID: 28032597
2. The data confirm that circulatory ST6Gal-1 is a negative systemic regulator of granulopoiesis PMID: 28550122
3. Data, including data from studies using knockout mice, suggest that extracellular St6gal1 supports extrinsic sialylation, however, other sialyltransferases appear to be present in systemic circulation. Platelet activation [as demonstrated with the FeCl(3) model of mesenteric artery thrombosis] is minimally sufficient to elicit extrinsic sialylation. PMID: 28717006
4. B-cell-specific ablation of ST6Gal1 in mice revealed that IgG sialylation can occur in the extracellular environment of the bloodstream independently of the B-cell secretory pathway. We also discovered that secreted ST6Gal1 is produced by cells lining central veins in the liver and that IgG sialylation is powered by serum-localized nucleotide sugar donor CMP-sialic acid that is at least partially derived from degranulat PMID: 27303031
5. findings suggest that ST6GAL1 has an inhibitory role in adipogenesis through integrin-beta1 activation, providing new insights into the roles and regulation mechanisms of glycans in adipocytes during obesity PMID: 28031460
6. this study proposes that remotely produced, rather than the endogenously expressed, ST6Gal-1 is the principal modifier of HSPC glycans for alpha2,6-sialic acids. In so doing, liver-produced ST6Gal-1 may be a potent systemic regulator of hematopoiesis. PMID: 24425878
7. Altered levels of ST6GAL1 are responsible for changed invasive properties of Hca-F and Hca-P cells both in vitro and in vivo. PMID: 23840320
8. Caveolin-1 up-regulates integrin alpha2,6-sialylation to promote integrin alpa5beta1-dependent hepatocarcinoma cell adhesion. PMID: 23416306
9. these results demonstrate for the first time that caveolin-1 can up-regulate ST6Gal-I expression and further contribute to promoting mouse hepatocarcinoma cell adhesion to fibronectin by activating FAK-mediated adhesion signaling. PMID: 23022190
10. Data indicate that the P1 promoter of the ST6Gal-1 gene is critical for Fc sialylation. PMID: 22427662
11. the loci of disulphide linkages in ST6Gal-I differ from those in ST3Gal I, suggesting that the linkage specificity of sialyltransferase may results from significant structural differences, including the loci of disulphide linkages (ST6Gal-I) PMID: 22039275
12. ST6Gal-I regulates macrophage apoptosis via alpha2-6 sialylation of the TNFR1 death receptor. PMID: 21930713
13. Data show that the sialyltransferase enzymes St6gal1 and St3gal4 are responsible for the production of sialyllactose in mouse milk. PMID: 21098096
14. circulatory ST6Gal-1, mostly of hepatic origin, limits myelopoiesis by a mechanism independent of hepatic sialylation of serum glycoproteins PMID: 20529847
15. The data implicate ST6Gal-1 as a participant in regulating not only Th1 but also Th2 responses, and ST6Gal-1 deficiency can lead to the development of more severe allergic inflammation with excessive eosinophil production. PMID: 20007243
16. tissue-specific alterations in sialylation and sialic acid 9-O-acetylation in knockout mice PMID: 12068010
17. ST6Gal I sialyltransferase has a role in regulating galectin-1-induced CD45 clustering, phosphatase modulation, and T cell death PMID: 12499376
18. Siat1deltaP1 animals can't raise liver Siat1 mRNA as inflammatory response; serum glycoprotein and B cells have normal sialylation; on exposure to S typhimurium, accumulation of neutrophils and greater burden in liver and spleen was observed. PMID: 12672700
19. Ras oncogene induces ST6gal1 via a RalGEF-mediated signal to its housekeeping promoter. PMID: 15355339
20. BACE1 cleaves ST6Gal I in vivo and controls the secretion of the E41 form of the ST6Gal I protein PMID: 15364953
21. Protein glycosylation by ST6Gal-I restricts access of antigen receptors and Shp-1 to CD22 and operates by a CD22-dependent mechanism. PMID: 16782884
22. role for ST6Gal-1, possibly from extramedullary sources (eg, produced in liver) in regulating inflammation, circulating neutrophil homeostasis, and replenishing granulocyte numbers. PMID: 16849643
23. soluble ST6Gal I produced by BACE1 plays, at least in part, a role in the sialylation of soluble glycoproteins PMID: 17897958
24. A role for ST6Gal-I as a mediator of tumor progression. PMID: 18199532
25. Reduced thymic cellularity in the ST6Gal I-deficient mice starting in the early thymocyte compartments. PMID: 18535087
26. ST6Gal I(-/-) mice show comparable numbers of IgG influenza-specific memory B cells and long-lived plasma cells, with similarly high antiviral IgG titers, with the exception of IgG2c PMID: 19342648

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KEGG: mmu:20440

STRING: 10090.ENSMUSP00000023601

UniGene: Mm.149029