Recombinant Mouse Band 4.1-like protein 5 (Epb41l5)

中文名稱：

小鼠Epb41l5重組蛋白
貨號：

CSB-YP806360MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Epb41l5重組蛋白
貨號：

CSB-EP806360MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Epb41l5重組蛋白
貨號：

CSB-EP806360MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Epb41l5重組蛋白
貨號：

CSB-BP806360MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Epb41l5重組蛋白
貨號：

CSB-MP806360MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Epb41l5
Uniprot No.：

Q8BGS1
別名：

Epb41l5; Epb4.1l5; Kiaa1548; Band 4.1-like protein 5
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達區域：

1-731
氨基酸序列

MLSFLRRTLG RRSMRKHAEK ERLREAQRAA THIPAAGDAK SIITCRVSLL DGTDVSVDLP KKAKGQELFD QIMYHLDLIE SDYFGLRFMD SAQVAHWLDG TKSIKKQVKI GSPYCLHLRV KFYSSEPNNL REELTRYLFV LQLKQDILSG KLECPFDTAV QLAAYNLQAE LGDYDLAEHS PELVSEFRFV PIQTEEMELA IFEKWKEYRG QTPAQAETNY LNKAKWLEMY GVDMHVVKAR DGNDYSLGLT PTGVLVFEGE TKIGLFFWPK ITRLDFKKNK LTLVVVEDDD QGKEQEHTFV FRLDHPKACK HLWKCAVEHH AFFRLRGPVQ KSSHRSGFIR LGSRFRYSGK TEYQTTKTNK ARRSTSFERR PSKRYSRRTL QMKASTTQPE DLGVLNASAQ KSDSQQAWGV MSPVPVTSSS SCGAVQVEIE NLPQTSATEQ HDRKCLPLSV DLLNSPDLLE TTIGDVTRTS ETSAPFPAPD TINVATRSNE LEEFKAECET LKDDTEKLKQ LETEQTILPS LRPTIDINVN SQEEVVKLTE KCLNNAIENP ALNAVKVPPD FKSNILKAQV EAVHKVTRED SLLTHKNASV QDAATNSTAF NENDVPVCKD SLTPVHGTAA DSASVLKDAT DELDALLLSL TENLMDHTVT PQVSSPSMIT PRWIIPQSAT ISNGLAGYGA SLAGTDECSQ KDGFSLISPP APFLVDAVTS SAPPLPEDST LKQKCLLTTE L
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Plays a role in the formation and organization of tight junctions during the establishment of polarity in epithelial cells.
基因功能參考文獻：
1. Genetic deletion of Epb41l5 resulted in severe proteinuria, detachment of podocytes, and development of focal segmental glomerulosclerosis. Remarkably, by binding and recruiting the RhoGEF ARGHEF18 to the leading edge, EPB41L5 directly controls actomyosin contractility and subsequent maturation of focal adhesions, cell spreading, and migration. PMID: 28536193
2. Left-right patterning in the mouse requires Epb4.1l5-dependent morphogenesis of the node and midline PMID: 20678497
3. Lulu mutation in Epb4.1l5 helps anchor the actin-myosin contractile machinery to the membrane to allow the dynamic rearrangements of epithelia that mediate embryonic morphogenesis. PMID: 17507402
4. the importance of a conserved Crumbs-MPP5-EPB41L5 polarity complex in mammals for separation of the apical and basolateral domains through specialized cell-cell junctions PMID: 17920587
5. Results describe the involvement of EPB41L5 in epithelial-mesenchymal transition during mouse gastrulation. PMID: 18794329
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亞細胞定位：

Cytoplasm. Cell junction, adherens junction. Cell membrane; Peripheral membrane protein. Photoreceptor inner segment.
組織特異性：

In the retina, expressed at the outer limiting membrane, retinal pigment epithelium, outer nuclear layer and outer plexiform layer (at protein level). Also detected in the inner segments (at protein level). Expressed at the basolateral and apical sides of
數據庫鏈接：

KEGG: mmu:226352

STRING: 10090.ENSMUSP00000058966

UniGene: Mm.253156