Recombinant Mouse BPI fold-containing family A member 1 (Bpifa1)

中文名稱：

Recombinant Mouse BPI fold-containing family A member 1(Bpifa1)
貨號：

CSB-YP018213MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Mouse BPI fold-containing family A member 1(Bpifa1)
貨號：

CSB-EP018213MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Mouse BPI fold-containing family A member 1(Bpifa1)
貨號：

CSB-EP018213MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Mouse BPI fold-containing family A member 1(Bpifa1)
貨號：

CSB-BP018213MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Mouse BPI fold-containing family A member 1(Bpifa1)
貨號：

CSB-MP018213MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Bpifa1
Uniprot No.：

P97361
別名：

Bpifa1; Plunc; Splunc1; BPI fold-containing family A member 1; Palate lung and nasal epithelium clone protein
種屬：

Mus musculus (Mouse)
蛋白長度：

Full Length of Mature Protein
表達區域：

20-278
氨基酸序列

Q LAGLPLPLGQ GPPLPLNQGP PLPLNQGQLL PLAQGLPLAV SPALPSNPTD LLAGKFTDAL SGGLLSGGLL GILENIPLLD VIKSGGGNSN GLVGGLLGKL TSSVPLLNNI LDIKITDPQL LELGLVQSPD GHRLYVTIPL GLTLNVNMPV VGSLLQLAVK LNITAEVLAV KDNQGRIHLV LGDCTHSPGS LKISLLNGVT PVQSFLDNLT GILTKVLPEL IQGKVCPLVN GILSGLDVTL VHNIAELLIH GLQFVIKV
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Lipid-binding protein which shows high specificity for the surfactant phospholipid dipalmitoylphosphatidylcholine (DPPC). Plays a role in the innate immune responses of the upper airways. Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae. Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid homeostasis and proper clearance of mucus. Plays a role in the airway inflammatory response after exposure to irritants. May attract macrophages and neutrophils.
基因功能參考文獻：
1. Bpifa1-deficient (Bpifa1-/-) mice exhibited spontaneous airway hyperresponsiveness and that excised tracheas from Bpifa1+/+ but not Bpifa1-/- mice were capable of reducing airway smooth muscle contraction. PMID: 28165446
2. this study shows that BPIFA1/SPLUNC1 restricts influenza A virus infection PMID: 28513596
3. SPLUNC1-knockout mice was established in a LPS-induced acute lung injury (ALI) mouse model to study the anti-inflammatory effect of SPLUNC1. Results found that SPLUNC1 deficiency upregulated levels of ALI-related cytokines leading to more severe lung injury after LPS injection. Moreover, further data discovered that the presence of SPLUNC1 can suppress the recruitment of CD11b+Gr-1+ MDSCs to the spleen in LPS-induced ALI. PMID: 29115527
4. Loss of Splunc1 predisposes mice to the development of otitis media. PMID: 25765466
5. SPLUNC1 is a crucial component of mucosal innate immune defense against pulmonary infection. PMID: 23499554
6. Knowledge of the complex expression patterns of BPIF proteins in these regions will allow the use of tractable mouse models of disease to dissect their function. PMID: 22986921
7. SPLUNC1 is present at high concentrations in murine airways under basal conditions, whereas it is suppressed by low-level environmental pathogen-associated molecular patterns and inflammatory signals. PMID: 23470624
8. SPLUNC1 KO mice demonstrated significantly higher numbers of eosinophils in the lung after OVA challenges than did wild-type mice. PMID: 22499853
9. Our findings demonstrate a critical in vivo role of SPLUNC1 in host defense against bacterial infection PMID: 21514430
10. Our data for the first time suggest that airway epithelial TLR2 signaling is pivotal in mycoplasma-induced SPLUNC1 production. PMID: 21054862
11. splunc5, splunc1, and lplunc1 are expressed in unique domains along a continuous corridor of oral, lingual, pharyngeal, and respiratory epithelia PMID: 15028288
12. SPLUNC1 protein decreases Mycoplasma pneumoniae (Mp) levels and inhibits epithelial IL-8 production induced by Mp-derived lipoproteins. PMID: 17785838
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亞細胞定位：

Secreted. Note=Apical side of airway epithelial cells. Detected in airway surface liquid, nasal mucus and sputum.
蛋白家族：

BPI/LBP/Plunc superfamily, Plunc family
組織特異性：

Detected in airway epithelia (trachea and lung) and in bronchoalveolar fluid (at protein level). Upper airways, nasopharyngeal epithelium and thymus. Highest expression in the trachea and progressive decrease from proximal (bronchial) to distal (bronchiol
數據庫鏈接：

KEGG: mmu:18843

STRING: 10090.ENSMUSP00000028985

UniGene: Mm.268852