Recombinant Mouse Aldehyde oxidase (Aox1), partial

中文名稱：

Recombinant Mouse Aldehyde oxidase(Aox1) ,partial
貨號：

CSB-YP001858MO
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Mouse Aldehyde oxidase(Aox1) ,partial
貨號：

CSB-EP001858MO
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Mouse Aldehyde oxidase(Aox1) ,partial
貨號：

CSB-EP001858MO-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Mouse Aldehyde oxidase(Aox1) ,partial
貨號：

CSB-BP001858MO
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Mouse Aldehyde oxidase(Aox1) ,partial
貨號：

CSB-MP001858MO
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Aox1
Uniprot No.：

O54754
別名：

Aox1; Ao; Ro; Aldehyde oxidase 1; EC 1.2.3.1; Azaheterocycle hydroxylase 1; EC 1.17.3.-; Retinal oxidase
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide, N-methylphthalazinium and phthalazine, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillin. Plays a role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Participates in the bioactivation of prodrugs such as famciclovir, catalyzing the oxidation step from 6-deoxypenciclovir to penciclovir, which is a potent antiviral agent. Also plays a role in the reductive metabolism of the xenobiotic imidacloprid (IMI) via its nitroreduction to nitrosoguanidine (IMI-NNO) and aminoguanidine (IMI-NNH(2)). Is probably involved in the regulation of reactive oxygen species homeostasis. May be a prominent source of superoxide generation via the one-electron reduction of molecular oxygen. Also may catalyze nitric oxide (NO) production via the reduction of nitrite to NO with NADH or aldehyde as electron donor. May play a role in adipogenesis. Cannot use xanthine and hypoxanthine as substrate.
基因功能參考文獻：
1. Although mAOX2 and mAOX3 are very similar to each other, we propose the following pairs of overlapping substrate specificities: mAOX2/mAOX4 and mAOX3/mAXO1. PMID: 25287365
2. findings suggest that AOX1 acts as a contributor to the process of myogenesis by influencing the level of H2O2 PMID: 24996175
3. These data indicate that AOX1 is essential for adipogenesis and may link energy and drug metabolism. PMID: 18671973
4. only Glu1265 is essential for catalytic activity by initiating the base-catalyzed mechanism of substrate oxidation PMID: 19401776
亞細胞定位：

Cytoplasm.
蛋白家族：

Xanthine dehydrogenase family
組織特異性：

Highest expression in esophagus. Moderately low expression in lung, liver, heart, Harderian gland, olfactory mucosa, skin and testis. In brain, expression is very high in choroid plexus, high in hind brain and low in hippocampus and cerebellum. In spinal
數據庫鏈接：

KEGG: mmu:11761

STRING: 10090.ENSMUSP00000001027

UniGene: Mm.26787