Recombinant Mouse Adenylate cyclase type 8 (Adcy8), partial

中文名稱：

Recombinant Mouse Adenylate cyclase type 8(Adcy8) ,partial
貨號(hào)：

CSB-YP001344MO
規(guī)格：
來(lái)源：

Yeast
其他：

中文名稱：

Recombinant Mouse Adenylate cyclase type 8(Adcy8) ,partial
貨號(hào)：

CSB-EP001344MO
規(guī)格：
來(lái)源：

E.coli
其他：

中文名稱：

Recombinant Mouse Adenylate cyclase type 8(Adcy8) ,partial
貨號(hào)：

CSB-EP001344MO-B
規(guī)格：
來(lái)源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Mouse Adenylate cyclase type 8(Adcy8) ,partial
貨號(hào)：

CSB-BP001344MO
規(guī)格：
來(lái)源：

Baculovirus
其他：

中文名稱：

Recombinant Mouse Adenylate cyclase type 8(Adcy8) ,partial
貨號(hào)：

CSB-MP001344MO
規(guī)格：
來(lái)源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Adcy8
Uniprot No.：

P97490
別名：

Adcy8Adenylate cyclase type 8; EC 4.6.1.1; ATP pyrophosphate-lyase 8; Adenylate cyclase type VIII; Adenylyl cyclase 8; Ca(2+)/calmodulin-activated adenylyl cyclase
種屬：

Mus musculus (Mouse)
蛋白長(zhǎng)度：

Partial
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Catalyzes the formation of cAMP in response to calcium entry leadings to cAMP signaling activation that affect processes suche as synaptic plasticity and insulin secretion. Plays a role in many brain functions, such as learning, memory, drug addiction, and anxiety modulation through regulation of synaptic plasticity by modulating long-term memory and long-term potentiation (LTP) through CREB transcription factor activity modulation. Plays a central role in insulin secretion by controlling glucose homeostasis through glucagon-like peptide 1 and glucose signaling pathway and maintains insulin secretion through calcium-dependent PKA activation leading to vesicle pool replenishment. Also, allows PTGER3 to induce potentiation of PTGER4-mediated PLA2 secretion by switching from a negative to a positive regulation, during the IL1B induced-dedifferentiation of smooth muscle cells.
基因功能參考文獻(xiàn)：
1. Genetic deletion of AC8 (adenylyl cyclase 8) but not AC1 abolished long-lasting anxiety. PMID: 27234425
2. Dysregulation of a survival pathway in adenylyl cyclase 1 and 8 knockout mice was identified following early-life ethanol exposure. PMID: 26992697
3. Study shows that AC8 is involved in epileptogenesis, and may serve as a potential target for the treatment of epilepsy PMID: 26656781
4. ADCY8 is required for the physiological activation of glucose-induced signalling pathways in beta cells, for glucose tolerance and for hypothalamic adaptation to a high-fat diet via regulation of islet insulin secretion. PMID: 25403481
5. these results support a complex role of cAMP signaling pathways confirming the involvement of AC8 in the modulation of stress responses. PMID: 20638449
6. ACVIII gene is regulated by CREB in vitro and in vivo and this regulation may contribute to CREB-dependent neural plasticity PMID: 12405989
7. AC8 accumulates in puncta of dendrites and axons in hippocampal neurons and localizes with synaptic marker proteins indicating synaptic and nonsynaptic cAMP signals generated by different Ca2+-stimulated adenylyl cyclases are required for mossy fiber LTP PMID: 14585998
8. AC8 expression is initially restricted to the epithalamus, the hypothalamus, the superior colliculus, the cerebellar anlage the proliferative zone of the rhombic lip, and the spinal cord. PMID: 15844169
9. AC8 protein levels were abundant during development, with diffuse and increasing expression in the hippocampus that intensified in the CA1/CA2 region by adulthood. in the presynaptic active zone and extrasynaptic fractions. PMID: 17335981
10. data suggest that AC1/AC8 are crucial activators of cell survival signaling pathways acutely following ethanol exposure and represent molecular factors that may directly modulate the severity of symptoms associated with Fetal Alcohol Syndrome PMID: 18992344
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亞細(xì)胞定位：

Cell membrane; Multi-pass membrane protein. Basolateral cell membrane. Apical cell membrane. Cell junction, synapse. Cell projection, dendrite. Cell projection, axon. Cell junction, synapse, presynaptic cell membrane. Cell junction, synapse, postsynaptic density. Membrane raft. Membrane, coated pit. Cytoplasmic vesicle, clathrin-coated vesicle membrane. Membrane, caveola.
蛋白家族：

Adenylyl cyclase class-4/guanylyl cyclase family
組織特異性：

Abundantly expressed within the olfactory bulb, thalamus, habenula, CA1 region of the hippocampus, and hypothalamus. Strongly expressed in pyramidal cells of CA1 and weakly in CA3 and the dentate gyrus. Strongly and homogeneously expressed in all cell lay
數(shù)據(jù)庫(kù)鏈接：

KEGG: mmu:11514

STRING: 10090.ENSMUSP00000023007

UniGene: Mm.1425