Recombinant Mouse Acetyl-CoA carboxylase 1 (Acaca), partial

中文名稱：

Recombinant Mouse Acetyl-CoA carboxylase 1(Acaca) ,partial
貨號：

CSB-YP729191MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Mouse Acetyl-CoA carboxylase 1(Acaca) ,partial
貨號：

CSB-EP729191MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Mouse Acetyl-CoA carboxylase 1(Acaca) ,partial
貨號：

CSB-EP729191MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Mouse Acetyl-CoA carboxylase 1(Acaca) ,partial
貨號：

CSB-BP729191MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Mouse Acetyl-CoA carboxylase 1(Acaca) ,partial
貨號：

CSB-MP729191MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Acaca
Uniprot No.：

Q5SWU9
別名：

Acaca; Acac; Gm738Acetyl-CoA carboxylase 1; ACC1; EC 6.4.1.2; ACC-alpha; Acetyl-CoA carboxylase 265
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Cytosolic enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis. This is a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA.
基因功能參考文獻：
1. the present studies report for the first time a role of ACC1 in suppressing breast cancer migration and invasion by an fatty acid synthesis-independent, but acetyl-CoA-dependent, impact on the epithelial-mesenchymal transition programs in breast tumor cells and its subsequent importance for tumor invasion and recurrence. PMID: 29056512
2. madecassic acid was the active form of madecassoside in ameliorating colitis by restoring the Th17/Treg balance via regulating the PPARgamma/AMPK/ACC1 pathway. PMID: 28358365
3. Studied a role for ACAC inactivation in meiotic resumption by testing the effect of two ACAC inhibitors, CP-640186 and Soraphen A, on mouse oocytes maintained in meiotic arrest in vitro. PMID: 26043180
4. Results suggest an essential role for acetyl coenzyme A carboxylase 1 (ACC1)-mediated de novo lipogenesis as a regulator of CD8(+) T cell expansion. PMID: 24567531
5. the stimulation of fatty acid oxidation by modulating the AMPK-ACC-CPT-1 pathway may be part of a protective mechanism against saturated free fatty acids that drive podocyte death. PMID: 24338821
6. A biotin analog inhibits acetyl-CoA carboxylase activity and adipogenesis PMID: 11907024
7. Expression of the isoenzyme of Acc1 is mediated by MyoD and MRF4 is differentially affected by retinoic acid receptor and retinoid X receptor. PMID: 12642900
8. Mutant mice lacking acetyl-CoA carboxylase 1 are embryonically lethal. PMID: 16103361
9. when fed fat-free diet for 10 days, there was significant up-regulation of PPARgamma and several enzymes in the lipogenic pathway in the liver of liver-specific ACC1 knockout mice compared with the WT mice PMID: 16717184
10. description of a pathway in which Tribbles 3 (TRB3) stimulates lipolysis by triggering the degradation of acetyl-coenzyme A carboxylase (ACC) in adipose tissue; TRB3 promoted ACC ubiquitination through an association with the E3 ubiquitin ligase COP1 PMID: 16794074
11. Hepatic de novo lipogenesis is present in liver-specific ACC1-deficient mice. PMID: 17210641
12. Downregulation of ACC1 on osteoblastogenesis may be the cause for the osteopenia phenotype of FACC1 knockout bone homeostasis. PMID: 19805143
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亞細胞定位：

Cytoplasm, cytosol.
數據庫鏈接：

KEGG: mmu:107476

STRING: 10090.ENSMUSP00000020843

UniGene: Mm.31374