Recombinant Mouse AKT-interacting protein (Aktip)

中文名稱：

Recombinant Mouse AKT-interacting protein(Aktip)
貨號：

CSB-YP737354MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Mouse AKT-interacting protein(Aktip)
貨號：

CSB-EP737354MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Mouse AKT-interacting protein(Aktip)
貨號：

CSB-EP737354MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Mouse AKT-interacting protein(Aktip)
貨號：

CSB-BP737354MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Mouse AKT-interacting protein(Aktip)
貨號：

CSB-MP737354MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Aktip
Uniprot No.：

Q64362
別名：

Aktip; Fif; Ft1; FtsAKT-interacting protein; FT1; Fused toes protein
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達區域：

1-292
氨基酸序列

MNPLWSMSAG SVRKRAEGEE KTLAGDVKTS PPRSAPKKQL PSIPKNALPI AKPTSPAPAA QSTNGTHASY GPFYLEYSLL AEFTLVVKQK LPGVYVQPSY RSALVWFGVI FIRHGLYQDG VFKFTVYIPD NYPDGDCPRL LFDIPVFHPL VDPTSGELDV KRAFAKWRRN HNHIWQVLMY ARRVFYKIDT TSPLNPEAAV LYEKDIQLFK SKVVDSVKVC TARLFDQPKI EDPYAISFSP WNPSVHDEAR EKMLTQKKPD EQHNKSVHVA GLSWVKPGSV QPFSKEEKTV AT
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade. FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell.
基因功能參考文獻：
1. Ft1 protein is required for telomere maintenance. PMID: 26110528
2. Primordial germ cell proliferation is impaired in Fused Toes mutant embryos. PMID: 20969841
3. Owing to a deletion, six genes, including the entire IroquoisB (IrxB) gene cluster, are directly affected by the Ft mutation. PMID: 11956760
4. Ft genes play an important role in dorsal-ventral patterning of the neural tube acting to define the extent of motor neuron generation PMID: 15789444
5. Defects in brain patterning and head morphogenesis are caused by mutations in Fused toes gene. PMID: 17241623
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相關疾病：

Defects in Aktip are a cause of embryonic death in homozygous animals. Death occurs at about 10 days of development. Symptoms include loss of left-right asymmetry, malformation of the developing brain and of the spinal cord, syndactyly and polydactyly. Heterozygous animals are characterized by polydactyly and thymic hyperplasia.
亞細胞定位：

Cytoplasm. Cell membrane; Peripheral membrane protein.
蛋白家族：

Ubiquitin-conjugating enzyme family, FTS subfamily
組織特異性：

Ubiquitous. Highest expression in kidney, testis and brain and lowest in spleen and liver.
數據庫鏈接：

KEGG: mmu:14339

STRING: 10090.ENSMUSP00000105238

UniGene: Mm.324588