Recombinant Mouse A-kinase anchor protein 1, mitochondrial (Akap1), partial

中文名稱：

Recombinant Mouse A-kinase anchor protein 1, mitochondrial(Akap1) ,partial
貨號：

CSB-YP001518MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Mouse A-kinase anchor protein 1, mitochondrial(Akap1) ,partial
貨號：

CSB-EP001518MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Mouse A-kinase anchor protein 1, mitochondrial(Akap1) ,partial
貨號：

CSB-EP001518MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Mouse A-kinase anchor protein 1, mitochondrial(Akap1) ,partial
貨號：

CSB-BP001518MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Mouse A-kinase anchor protein 1, mitochondrial(Akap1) ,partial
貨號：

CSB-MP001518MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Akap1
Uniprot No.：

O08715
別名：

Akap1; AkapA-kinase anchor protein 1; mitochondrial; Dual specificity A-kinase-anchoring protein 1; D-AKAP-1; Protein kinase A-anchoring protein 1; PRKA1; Spermatid A-kinase anchor protein; S-AKAP
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A. Anchors them to the cytoplasmic face of the mitochondrial outer membrane or allows them to reside in the endoplasmic reticulum. Involved in mitochondrial-mediated antiviral innate immunity. Promotes translocation of NDUFS1 into mitochondria to regulate mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) activity. Under diabetic conditions, myocardial AKAP1 expression decreases which blocks the translocation of NDUFS1 from the cytosol to mitochondria. Reduction of NDUFS1 in mitochondria decreases ATP production and increases mitochondrial ROS level, which causes mitochondrial dysfunction and cell apoptosis, respectively, thereby leading to cardiac dysfunction.
基因功能參考文獻：
1. these results identify a novel AKAP-mediated biochemical mechanism that increases TRPA1 sensitivity in peripheral sensory neurons, and likely contributes to persistent mechanical hypersensitivity. PMID: 28500286
2. AKAP1 is a transcriptional target of Myc, and it supports mTOR pathway and the growth of cancer cells. PMID: 28569781
3. Genetic ablation of AKAP7 specifically from dentate granule cells results in disruption of mossy fiber-CA3 pyramidal neuron long-term potentiation directly initiated by cAMP, and the AKAP7 mutant mice are selectively deficient in pattern separation behaviors. The results suggest that the AKAP7/PKA complex in the mossy fiber projections plays an essential role in synaptic plasticity and contextual memory formation. PMID: 27911261
4. The results demonstrate that Akap1 deficiency promotes cardiac mitochondrial aberrations and mitophagy, enhancing infarct size, pathological cardiac remodeling and mortality under ischemic conditions. PMID: 27136357
5. The tongue epithelium is differentiated into multiple epithelial cell layers via the PI3K and PKA pathways in tissue-specific manner during the epithelial-mesenchymal interactions. PMID: 27939449
6. Data suggest that D-AKAP1 is a transmembrane protein in mitochondrial outer membrane; D-AKAP1 appears to participate in cAMP signaling; hydrophobicity of D-AKAP1 transmembrane domain regulates localization to either ER or mitochondria. PMID: 26950402
7. db/db/ mice PMID: 24425205
8. NCX3 regulates mitochondrial calcium handling from the outer mitochondrial membrane through an AKAP121-anchored signaling complex. PMID: 24101730
9. PKC and PKA regulate AChR dynamics at the neuromuscular junction of living mice. PMID: 24260568
10. Activation of NOD1 induces lipolysis through NF-kappaB and the lipolytic PKA activation in 3T3-L1 adipocytes. PMID: 24219284
11. hypoxia induces fission of mitochondrial membranes, dependent on availability of protein AKAP121 PMID: 22099302
12. Six putative caspase substrates, including five novel proteins (ABCF1, AKAP1, CPE, DOPEY1 and GOPC1) that may be targeted specifically by the initiator caspases 8 and 10 during the early stages of apoptosis, were identified.[caspase 10] PMID: 18288386
13. AKAP121 regulates the response to stress in cardiomyocytes, and therefore AKAP121 downregulation might represent an important event contributing to the development of cardiac dysfunction. PMID: 20511238
14. AKAP1 is a bifunctional helical element that is required for both ER and mitochondrion targeting. PMID: 11994283
15. Purified tubulin binds directly to S-AKAP84 but not to a deletion mutant lacking the mitochondrial targeting domain (MT) at residues 1-30. PMID: 12096916
16. AKAP121, through its role in enhancing cAMP and tyrosine kinase signaling to distal organelles, is an important regulator in mitochondrial metabolism PMID: 16251349
17. Protein Kinase A interaction with AKAPs is essential for two sequential steps in the maturation process: the initial maintenance of meiotic arrest and the subsequent irreversible progression to the polar body extruded stage PMID: 16461287
18. AKAP121 and PKAR2A serve to enhance steroidogenesis by directing the synthesis and activation of STAR at the mitochondria in response to cAMP. PMID: 17989356
19. dAKAP1 possesses a single targeting element capable of targeting to both mitochondria and ER, with the ER signal overlapping the mitochondria signal PMID: 18287098
20. AKAP121 levels are regulated post-translationally by the ubiquitin/proteasome pathway. PMID: 18323779
21. LPL translational inhibition occurs through an RNA-binding complex involving PKA subunits and AKAP121, and this complex can be activated either through traditional PKA activation methods or through the depletion of PKCalpha PMID: 18387001
顯示更多

收起更多
亞細胞定位：

Mitochondrion outer membrane. Mitochondrion.; [Isoform 2]: Endoplasmic reticulum.; [Isoform 4]: Endoplasmic reticulum.; [Isoform 1]: Mitochondrion outer membrane.; [Isoform 3]: Mitochondrion outer membrane.; [Isoform 5]: Mitochondrion outer membrane.; [Isoform 6]: Mitochondrion outer membrane.
組織特異性：

Highest expression in testis, heart, liver, skeletal muscle, intestine and kidney, followed by brain and lung. No expression in spleen. Isoform 1/D-AKAP1A is expressed predominantly in testis whereas isoform 4/D-AKAP1D is expressed primarily in liver. Exp
數據庫鏈接：

KEGG: mmu:11640

STRING: 10090.ENSMUSP00000018572

UniGene: Mm.2969