Recombinant Mouse 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 (Plcb3), partial

中文名稱：

小鼠Plcb3重組蛋白
貨號(hào)：

CSB-YP018128MO
規(guī)格：
來(lái)源：

Yeast
其他：

中文名稱：

小鼠Plcb3重組蛋白
貨號(hào)：

CSB-EP018128MO
規(guī)格：
來(lái)源：

E.coli
其他：

中文名稱：

小鼠Plcb3重組蛋白
貨號(hào)：

CSB-EP018128MO-B
規(guī)格：
來(lái)源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Plcb3重組蛋白
貨號(hào)：

CSB-BP018128MO
規(guī)格：
來(lái)源：

Baculovirus
其他：

中文名稱：

小鼠Plcb3重組蛋白
貨號(hào)：

CSB-MP018128MO
規(guī)格：
來(lái)源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Plcb3
Uniprot No.：

P51432
別名：

Plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3; EC 3.1.4.11; Phosphoinositide phospholipase C-beta-3; Phospholipase C-beta-3; PLC-beta-3
種屬：

Mus musculus (Mouse)
蛋白長(zhǎng)度：

Partial
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
基因功能參考文獻(xiàn)：
1. Data, including data from studies using transgenic/knockout mice, suggest that Ppp1ca and Gnb1 interact in quiescent platelets; then, Ppp1ca and Plcb3 interact during platelet aggregation; thus, Gnb1 enlists Ppp1ca to modulate G protein-coupled receptor signaling. (Ppp1ca = protein phosphatase 1, catalytic subunit alpha; Gnb1 = guanine nucleotide-binding protein, subunit beta-1; Plcb3 = phospholipase C, subunit beta-3) PMID: 28615442
2. Plcb3-deficient mice spontaneously develop atopic dermatitis-like skin lesions. PMID: 24412367
3. Data suggest that PLCbeta3 acts as a negative regulator of VEGF- (vascular endothelial growth factor A-) mediated vascular hyperpermeability through intracellular calcium signaling. PMID: 22674805
4. defined a PLC-beta3- and SHP-1-mediated signaling pathway for FcvarepsilonRI-mediated cytokine production PMID: 21683628
5. Cellular G(i)-G(q) synergism derives from direct supra-additive stimulation of phospholipase C-beta3 by G protein subunits Gbetagamma and Galpha(q). PMID: 20579885
6. Expression of Plcb3 was studied in a cell line during myoblast differentiation. PMID: 15174099
7. results suggest that activation of PLC-b3 by pertussis toxin-sensitive G proteins is responsible for transient [Ca2+]i increase in response to thrombin PMID: 15995354
8. GPCR agonists ET-1, LPA, and thrombin activate PLCepsilon and PLCbeta3 in fibroblasts. Activation of these PLC isoforms displays agonist-specific temporal profiles; PLCbeta3 is predominantly involved in acute and PLCepsilon in sustained PI hydrolysis PMID: 16314422
9. The pattern of phospholipase Cbeta3 expression is unique, revealing stripes in three of the four transverse zones and a uniform distribution in the fourth. and PLCbeta3 is restricted to the zebrin II-immunopositive Purkinje cell subset. PMID: 16566000
10. These results demonstrate that PLCbeta3 is required to mediate "itch" sensation in response to histamine acting on the histamine H1 receptor in C-fiber nociceptive neurons. PMID: 17114052
11. PLCbeta3 plays a major role in mediating mGluR1-dependent synaptic transmission, plasticity, and integration in PLCbeta3-dominant Purkinje cells PMID: 17298601
12. a novel role for PLC activity in promoting macrophage survival in atherosclerotic plaques and identify PLC beta3 as a potential target for treatment of atherosclerosis. PMID: 18079968
13. PLCbeta3 may provide a selective target for inhibiting Ca(2+) responses to mediators of inflammation, including C5a, UDP, PAF, and LPA PMID: 18411281
14. Deficiencies in PLC-beta3 are associated with the development of myeloproliferative disease, lymphoma, and other tumors. PMID: 19647226
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亞細(xì)胞定位：

Cytoplasm. Membrane. Nucleus.
組織特異性：

Highly expressed in kidney, skeletal muscle, liver, lung, heart and brain.
數(shù)據(jù)庫(kù)鏈接：

KEGG: mmu:18797

STRING: 10090.ENSMUSP00000025912

UniGene: Mm.273204