Recombinant Human herpesvirus 8 type P E3 ubiquitin-protein ligase MIR1 (K3), partial

中文名稱：

Recombinant Human herpesvirus 8 type P E3 ubiquitin-protein ligase MIR1(K3),partial
貨號：

CSB-YP308971HKE
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Human herpesvirus 8 type P E3 ubiquitin-protein ligase MIR1(K3),partial
貨號：

CSB-EP308971HKE
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Human herpesvirus 8 type P E3 ubiquitin-protein ligase MIR1(K3),partial
貨號：

CSB-EP308971HKE-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Human herpesvirus 8 type P E3 ubiquitin-protein ligase MIR1(K3),partial
貨號：

CSB-BP308971HKE
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Human herpesvirus 8 type P E3 ubiquitin-protein ligase MIR1(K3),partial
貨號：

CSB-MP308971HKE
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

K3
Uniprot No.：

P90495
別名：

K3E3 ubiquitin-protein ligase MIR1; EC 2.3.2.27; IE1B protein; Modulator of immune recognition 1; ORF K3; RING-type E3 ubiquitin transferase MIR1
種屬：

Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

E3 ubiquitin-protein ligase which promotes ubiquitination and subsequent degradation of host MHC-I and CD1D molecules, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes. Binds target molecules through transmembrane interaction. E3 ubiquitin-protein ligases accept ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfer it to target protein. The result of this ubiquitination is the enhancement of the endocytosis of the target chain and the delivery to the lysosome, where it is proteolytically destroyed. Induces ubiquitination not only on lysines, but also on cysteine residues.
基因功能參考文獻：
1. the down-regulation of cell surface MHC class I, polyubiquitinated by the KSHV K3 ubiquitin ligase, does not employ the canonical ESCRT pathway PMID: 26221024
2. K3-mediated inhibition of T cell receptor-driven transendothelial migration of effector memory CD4-positive T cells can be explained by ubiquitin-dependent downregulation of platelet endothelial cell adhesion molecule-1 (PECAM-1). PMID: 20357254
亞細胞定位：

Host cell membrane; Multi-pass membrane protein. Host endoplasmic reticulum. Note=Probably exerts its effects at the plasma membrane during viral infection.
數據庫鏈接：

KEGG: vg:4961486