Recombinant Human herpesvirus 1 Neurovirulence factor ICP34.5 (RL1)

中文名稱：

Recombinant Human herpesvirus 1 Neurovirulence factor ICP34.5(RL1)
貨號：

CSB-YP327659HJO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Human herpesvirus 1 Neurovirulence factor ICP34.5(RL1)
貨號：

CSB-EP327659HJO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Human herpesvirus 1 Neurovirulence factor ICP34.5(RL1)
貨號：

CSB-EP327659HJO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Human herpesvirus 1 Neurovirulence factor ICP34.5(RL1)
貨號：

CSB-BP327659HJO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Human herpesvirus 1 Neurovirulence factor ICP34.5(RL1)
貨號：

CSB-MP327659HJO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

RL1
Uniprot No.：

P37319
別名：

RL1; ICP34.5Neurovirulence factor ICP34.5; Infected cell protein 34.5; protein gamma(1)34.5
種屬：

Human herpesvirus 1 (strain MGH-10) (HHV-1) (Human herpes simplex virus 1)
蛋白長度：

full length protein
表達區域：

1-245
氨基酸序列

MARRRRRHRG PRRPRPPGPT GAVPTAQSQV TSTPNSEPVV RSAPAAGGPP PSCSLLLRQW LHVPESASDD DDDDDWPDSP PPEPAPEARP TAAAPRPRSP PPGAGPGGGA NPSHPPSRPF RLPPRLALRL RVTAEHLARL RLRRAGGEGA PKPPATPATP ATPATPATPA TPARVRFSPH VRVRHLVVWA SAARLARRGS WARERADRAR FRRRVAEAEA VIGPCLGPEA RARALARGAG PANSV
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Plays essential roles in viral nuclear egress to mediate capsid transit across the nuclear membrane and also in the inhibition of host immune response. Facilitates nuclear egress cooperatively with host C1QBP and protein kinase C/PKC to induce lamin A/C phosphorylation and subsequent reorganization. In turn, lamina disassembles and nuclear egress occurs. Recruits the serine/threonine protein phosphatase PPP1CA/PP1-alpha to dephosphorylate the translation initiation factor eIF-2A, thereby couteracting the host shutoff of protein synthesis involving double-stranded RNA-dependent protein kinase EIF2AK2/PKR. In turn, controls host IRF3 activation and subsequently inhibits host interferon response. Controls the DNA sensing pathway by interacting with and inhibiting host STING/TMEM173. Also down-modulates the host MHC class II proteins cell surface expression. Acts as a neurovirulence factor that has a profound effect on the growth of the virus in central nervous system tissue, by interqcting with host BECN1 and thereby antagonizing the host autophagy response.
亞細胞定位：

Host cytoplasm. Host nucleus. Host nucleus, host nucleolus. Virion.
蛋白家族：

PPP1R15 family