Recombinant Human Zinc finger protein PLAGL2 (PLAGL2)

中文名稱：

人PLAGL2重組蛋白
貨號：

CSB-YP891980HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人PLAGL2重組蛋白
貨號：

CSB-EP891980HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人PLAGL2重組蛋白
貨號：

CSB-EP891980HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人PLAGL2重組蛋白
貨號：

CSB-BP891980HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人PLAGL2重組蛋白
貨號：

CSB-MP891980HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

PLAGL2
Uniprot No.：

Q9UPG8
別名：

C2H2 type zinc finger protein ; KIAA0198; PLAGL2; PLAL2_HUMAN; Pleiomorphic adenoma gene-like 2; Pleiomorphic adenoma-like protein 2; Zinc finger protein PLAGL2; ZNF900
種屬：

Homo sapiens (Human)
蛋白長度：

full length protein
表達區域：

1-496
氨基酸序列

MTTFFTSVPP WIQDAKQEEE VGWKLVPRPR GREAESQVKC QCEISGTPFS NGEKLRPHSL PQPEQRPYSC PQLHCGKAFA SKYKLYRHMA THSAQKPHQC MYCDKMFHRK DHLRNHLQTH DPNKEALHCS ECGKNYNTKL GYRRHLAMHA ASSGDLSCKV CLQTFESTQA LLEHLKAHSR RVAGGAKEKK HPCDHCDRRF YTRKDVRRHL VVHTGRKDFL CQYCAQRFGR KDHLTRHVKK SHSQELLKIK TEPVDMLGLL SCSSTVSVKE ELSPVLCMAS RDVMGTKAFP GMLPMGMYGA HIPTMPSTGV PHSLVHNTLP MGMSYPLESS PISSPAQLPP KYQLGSTSYL PDKLPKVEVD SFLAELPGSL SLSSAEPQPA SPQPAAAAAL LDEALLAKSP ANLSEALCAA NVDFSHLLGF LPLNLPPCNP PGATGGLVMG YSQAEAQPLL TTLQAQPQDS PGAGGPLNFG PLHSLPPVFT SGLSSTTLPR FHQAFQ
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Shows weak transcriptional activatory activity.
基因功能參考文獻：
1. overexpression of miR-449a inhibited the expression of PLAGL2 significantly and the knockdown of PLAGL2 expression inhibited the breast cancer cell proliferation and metastasis PMID: 29653747
2. increased expression correlates to prostate cancer progression following radical prostatectomy and may serve as novel poor prognostic marker PMID: 27537362
3. Our findings indicated that PLAGL2 might be a very upstream key molecule regulating Epithelial-mesenchymal transition involved in Wnt/bcatenin signaling pathway in Colorectal adenocarcinoma PMID: 28259923
4. Our findings indicate that PALGL2 serves as a tumor oncoprotein in the development and progression of colorectal cancer PMID: 25031728
5. PLAGL2 expression induces lamellipodia formation and disruption of stress fiber formation. PMID: 24675530
6. PLAGL2 regulate cell cycle and apoptosis via activation of the p53 family member, p73, in human promonocytic U937 cells. PMID: 22076304
7. Transcriptome analysis revealed that these differentiation-suppressive activities are attributable in part to PLAGL2 modulation of Wnt/beta-catenin signaling PMID: 20478531
8. The data identify PC2 as a novel PLAGL2-binding protein and important mediator of PLAGL2 transactivation. PMID: 20025940
9. PLAGL2 may modulate SP-C expression during lung development. PMID: 15361364
10. Coexpression of Tip60 and PLAGL2 completely abolishes the sumoylation of PLAGL2. PMID: 17551969
11. Nuclear PLAGL2 occupied and transactivated the endogenous SP-C promoter in hypoxic lung cells.These results further suggest that PLAGL2 is an oxidative stress responding regulator in lung cells. PMID: 17618602
12. This study thus uncovers a novel function of PLAGL2 as an oncoprotein through regulating the stability of Pirh2. PMID: 17950244
13. These data suggests that Ubc9 can function as a co-factor of PLAGL2, uncoupling from its enzymatic activity, to mediate PLAGL2 interactive SP-C promoter activity. PMID: 18655774
14. Increased cell injury and/or death could be caused directly by the upregulation of bNip3, a preapoptotic molecule that dimerizes with Bcl-2, or indirectly by the aberrant expression of SP-C-induced endoplasmic reticulum stress in epithelial cells. PMID: 19574421
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亞細胞定位：

Nucleus.
蛋白家族：

Krueppel C2H2-type zinc-finger protein family
數據庫鏈接：

HGNC: 9047

OMIM: 604866

KEGG: hsa:5326

STRING: 9606.ENSP00000246229

UniGene: Hs.154104