Recombinant Human Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (SVEP1), partial

中文名稱：

人SVEP1重組蛋白
品名簡稱：

Recombinant Human SVEP1 protein, partial
貨號：

CSB-EP689809HUb1
說明書：

MSDS Datasheet
規格：

￥2328
圖片：
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

Greater than 95% as determined by SDS-PAGE.
生物活性：

Not Test
基因名：

SVEP1
Uniprot No.：

Q4LDE5
別名：

CCP module-containing protein 22;Polydom;Selectin-like osteoblast-derived protein;SEL-OB;Serologically defined breast cancer antigen NY-BR-38
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
來源：

E.coli
分子量：

18.0 kDa
表達區域：

736-827aa
氨基酸序列

GDFICTPDNTGVNCTLTCLEGYDFTEGSTDKYYCAYEDGVWKPTYTTEWPDCAKKRFANHGFKSFEMFYKAARCDDTDLMKKFSEAFETTLG
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 10xHis-tagged and C-terminal Myc-tagged
產品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

May play a role in the cell attachment process.
基因功能參考文獻：
1. Downregulation of SVEP1 expression in primary keratinocytes resulted in decreased expression of major epidermal differentiation markers. PMID: 27892606
2. Top association findings suggested that the bipolar disorder risk allele at SNP rs7042161 in SVEP1 gene may be associated with increased risk of essential hypertension. PMID: 27529678
3. We also found significant associations between coronary artery disease and low-frequency missense variants in the genes SVEP1. PMID: 26934567
4. c.2080A>C SNP associated with increased 28-day mortality in septic shock PMID: 25188548
5. polydom is a hitherto unknown ligand for integrin alpha9beta1 that functions as a physiological ligand in vivo. PMID: 22654117
6. Increased UT-II, sTM, and vWF in ankylosing spondylitis patient sera regardless of treatment and disease activity suggest an increased tendency for atherosclerosis. PMID: 21556780
7. acts as regulator of ICAM1 and E-selectin during endotoxemia PMID: 20236627
8. All together makes SEL-OB/SVEP1 an attractive marker for studying the role of stromal osteogenic cells and their interactions within the bone marrow microenvironment creating a network that regulates the skeletal homeostasis. PMID: 16206243
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亞細胞定位：

Secreted. Cytoplasm. Membrane; Peripheral membrane protein.
組織特異性：

Present in mesenchymal primary cultured cell lysates (at protein level). Highly expressed in placenta. Also expressed in marrow stromal cell. Weakly or not expressed in other tissues.
數據庫鏈接：

HGNC: 15985

OMIM: 611691

KEGG: hsa:79987

STRING: 9606.ENSP00000384917

UniGene: Hs.522334