Recombinant Human Sulfatase-modifying factor 2 (SUMF2)

中文名稱：

人SUMF2重組蛋白
貨號：

CSB-YP839844HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人SUMF2重組蛋白
貨號：

CSB-EP839844HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人SUMF2重組蛋白
貨號：

CSB-EP839844HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人SUMF2重組蛋白
貨號：

CSB-BP839844HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人SUMF2重組蛋白
貨號：

CSB-MP839844HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

SUMF2
Uniprot No.：

Q8NBJ7
別名：

SUMF2; PSEC0171; UNQ1968/PRO4500; Inactive C-alpha-formylglycine-generating enzyme 2; Paralog of formylglycine-generating enzyme; pFGE; Sulfatase-modifying factor 2
種屬：

Homo sapiens (Human)
蛋白長度：

Full Length of Mature Protein
表達區域：

26-301
氨基酸序列

QATSM VQLQGGRFLM GTNSPDSRDG DGPVREATVK PFAIDIFPVT NKDFRDFVRE KKYRTEAEMF GWSFVFEDFV SDELRNKATQ PMKSVLWWLP VEKAFWRQPA GPGSGIRERL EHPVLHVSWN DARAYCAWRG KRLPTEEEWE FAARGGLKGQ VYPWGNWFQP NRTNLWQGKF PKGDKAEDGF HGVSPVNAFP AQNNYGLYDL LGNVWEWTAS PYQAAEQDMR VLRGASWIDT ADGSANHRAR VTTRMGNTPD SASDNLGFRC AADAGRPPGE L
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Lacks formylglycine generating activity and is unable to convert newly synthesized inactive sulfatases to their active form. Inhibits the activation of sulfatases by SUMF1.
基因功能參考文獻：
1. SUMF2 interacted with IL-13 and inhibited IL-13 secretion in bronchial smooth muscle cells and lymphocytes, which was independent of IL-13 glycosylation PMID: 19739097
2. structural analysis of human pFGE by X-ray crystallography [pFGE] PMID: 15687489
3. pFGE (SUMF2) is the paralog of the Calpha-formylglycine-generating enzyme PMID: 15708861
4. SUMF2 interacts with sulphatase-modifying factor 1 to regulate sulphatase activities. PMID: 15962010
5. pFGE is retained in the ER through its C-terminal tetrapeptide PGEL, a noncanonical variant of the classic KDEL ER-retention signal. PMID: 18266766
顯示更多

收起更多
亞細胞定位：

Endoplasmic reticulum lumen.
蛋白家族：

Sulfatase-modifying factor family
組織特異性：

Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Highest levels in kidney, liver and placenta.
數據庫鏈接：

HGNC: 20415

OMIM: 607940

KEGG: hsa:25870

STRING: 9606.ENSP00000341938

UniGene: Hs.279696